DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and AgaP_AGAP008033

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_317429.4	Gene:	AgaP_AGAP008033 / 1277919	VectorBaseID:	AGAP008033	Length:	364	Species:	Anopheles gambiae

Alignment Length:	377	Identity:	165/377 - (43%)
Similarity:	236/377 - (62%)	Gaps:	50/377 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TQVMGRFRVVVN-PR---------DYCHLAPL--------------KRSRYHQRSEFGCRPLCSN 50
            :.:..||.:.:| ||         .:.:.||:              .:..|::|.:....||...
Mosquito     8 SSLASRFFISINHPRIAPLTIPLASFTNHAPIPANGTNHQLHQNGSNKDDYNRRKQRTAGPLHFI 72

  Fly    51 AAGYEVSWAAPPASGSSGGMFWAFSAAFTLNLFGGADEKEETPEEKLIKTIKRSILCIQREQYDK 115
            ||...:||                        |....:.|.|||.:||..||||||.||:|:|.|
Mosquito    73 AASSFLSW------------------------FSKKSDDENTPESQLITIIKRSILSIQKEEYQK 113

  Fly   116 AEQMLHLALRMAQDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKIL 180
            |||||||||:||||:||||||||::|:|||||||...|.||||:|.:||:|||::|..|:..|:|
Mosquito   114 AEQMLHLALKMAQDLQSKDGITYIYDIMANLAMEVGDFAKAEKLFVNVMQRLFSDGFLEDHIKML 178

  Fly   181 HISSKIAHMSQLQGDLEKSFQGFTWTLQQLAKLLEKMPDD--KDILELYGLTKNWFGQLLMKQGK 243
            |||||:||::||||.|:|:.|||.|||.:|.:.|:::.||  |:|.||:|:||||:.||||:..:
Mosquito   179 HISSKVAHLAQLQGHLDKAAQGFEWTLAKLEEKLKQLGDDNAKEIRELWGITKNWYAQLLMESKR 243

  Fly   244 YLEAKNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQ 308
            :.|||..|.:|::....::|.:.:..:|||||:|||..|||.||.|...|.||:.|..::.|.::
Mosquito   244 FAEAKQAFLQAYEAYTEIHGMLTEEGLTILNNLSVACSNLEDYASAERFLKEAIALAAQIPDLSE 308

  Fly   309 EGILQANLGLVYLREGLMSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIK 360
            .|:.:|||||:||::||:.||...|..||:.||||::.:.|:||.|||.:||
Mosquito   309 AGVYKANLGLLYLQQGLLRQASEFCTFAWRYGKQHKHEETVQQASYCLEQIK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	28/66 (42%)
		TPR repeat	269..299	CDD:276809	17/29 (59%)
		TPR_11	272..339	CDD:290150	33/66 (50%)
		TPR repeat	304..338	CDD:276809	15/33 (45%)
AgaP_AGAP008033	XP_317429.4	TPR repeat	219..265	CDD:276809	19/45 (42%)
		TPR_12	230..300	CDD:290160	31/69 (45%)
		TPR repeat	270..298	CDD:276809	17/27 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	186	1.000	Domainoid score	I6990
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9831
Inparanoid	1	1.050	315	1.000	Inparanoid score	I4901
OMA	1	1.010	-	-		QHG46748
OrthoDB	1	1.010	-	-		D369100at33208
OrthoFinder	1	1.000	-	-		FOG0007221
OrthoInspector	1	1.000	-	-		oto107158
Panther	1	1.100	-	-	LDO	PTHR13143
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15015
TreeFam	1	0.960	-	-
	13	12.940