DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc19 and ttc19

DIOPT Version :9

Sequence 1:	NP_609934.3	Gene:	Ttc19 / 35172	FlyBaseID:	FBgn0032744	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_002938292.3	Gene:	ttc19 / 100485992	XenbaseID:	XB-GENE-6258121	Length:	399	Species:	Xenopus tropicalis

Alignment Length:	380	Identity:	90/380 - (23%)
Similarity:	169/380 - (44%)	Gaps:	52/380 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CHLAPLKRSRYHQRSEFGCRPLCSNAAGYEVSWAAPP---------------------------A 63
            |.....:|:|.|      |:     .||...||.|..                           :
Frog    32 CVSCVAQRARNH------CQ-----QAGERTSWVAAASIRPKRITVSTSRPFPSCLVTFGKKRVS 85

  Fly    64 SGSSGGMFWAFSAAFTL-NLFGGADEKEETPEEKLIKTIKRSILCIQREQYDKAEQMLHLALRMA 127
            .|.....|...:|||:| :.||..:|:....|:.:|..:|::.|.|.:.:.::||::||.||.||
Frog    86 EGCRDLSFVMAAAAFSLFSYFGEKEEEVTEAEQDIILLLKKAKLSIMKGEMEEAEEILHQALNMA 150

  Fly   128 QDIQSKDGITYVFDLMANLAMEREQFKKAEKIFTDVMKRLFAEGHTEESPKILHISSKIAHMSQL 192
            ....|...|.|.:|||||||:...:...:||:|.:.:..:..:...::....:.||.|:|.:...
Frog   151 HKSGSTRAIIYTYDLMANLALLTGKLDTSEKLFKETLIFMLNDNIQQDDNAFIEISLKLASIYAT 215

  Fly   193 QGDLEKSFQGFTWTLQQLAKLLEKM---------PDDKDILE-LYGLTKNWFGQLLMKQGKYLEA 247
            |...|.:..|:.:.:..|.:.|||.         .|:|.... |.||..:.:|:.|:....:.:|
Frog   216 QNKKELAVAGYQFCILSLEEKLEKQAGLLEGSLAADEKSNTRLLLGLCLDSYGRYLINNSSFSQA 280

  Fly   248 KNLFKEAFDTLINVYGAVNDASVTILNNISVAYVNLEKYAEARETLLEAMELTKELKDATQEGIL 312
            :|::::|........|..:..||.::|:|::|...|.|:.||...:.:|.||.::.:......:|
Frog   281 QNMYEKALRICTEEQGTEHPQSVILMNDIAIALEALGKHDEAFAIVNQASELARKTEHPDLHVVL 345

  Fly   313 QANLGLVYLREGL--MSQAENACRLAWKLGKQHQNPDAVEQAEYCLNEIKTTLNG 365
             :||.::...:|.  .::||...:.|.:..::..:..:|:..:..|.|:.....|
Frog   346 -SNLAMILTYQGKEHFAEAERIFKEALEHSEKKGDSASVQYIQEGLAELDRRKKG 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc19	NP_609934.3	TPR_12	235..302	CDD:290160	18/66 (27%)
		TPR repeat	269..299	CDD:276809	10/29 (34%)
		TPR_11	272..339	CDD:290150	17/68 (25%)
		TPR repeat	304..338	CDD:276809	7/35 (20%)
ttc19	XP_002938292.3	PEP_TPR_lipo	<123..376	CDD:274350	65/253 (26%)
		TPR_12	255..335	CDD:315987	21/79 (27%)
		TPR repeat	302..332	CDD:276809	10/29 (34%)
		TPR_12	304..376	CDD:315987	17/72 (24%)
		TPR repeat	342..372	CDD:276809	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8995
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9831
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4821
OMA	1	1.010	-	-		QHG46748
OrthoDB	1	1.010	-	-		D369100at33208
OrthoFinder	1	1.000	-	-		FOG0007221
OrthoInspector	1	1.000	-	-		oto103046
Panther	1	1.100	-	-	LDO	PTHR13143
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4032
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110