DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and Mib2

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_006539310.1	Gene:	Mib2 / 76580	MGIID:	2679684	Length:	982	Species:	Mus musculus

Alignment Length:	1090	Identity:	429/1090 - (39%)
Similarity:	600/1090 - (55%)	Gaps:	158/1090 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQ 67
            |.:..|:|||||.:|.|..||.|||.||||.|:||.||..:|:.||||.||.|.|||||.|||..
Mouse     7 AGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGA 71

  Fly    68 YDLIIVDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTP 132
            :||::.||||:|:||.|::||.|.|.|:.|:.:||..|.:|.||..||..:.||:.|.|.||.|.
Mouse    72 HDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETS 136

  Fly   133 NSLGVRLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANV 197
            :|..|.|..|:|..||.|||||.|:||||||||||..||||||:||||::|||||.|:.||||:|
Mouse   137 HSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASV 201

  Fly   198 AWVTGSTNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVC 262
            .|..|:|||||:||||.|||:.:....||.|||:|:|.||:..|||.........|..||:||..
Mouse   202 TWADGTTNVYRVGHKGKVDLRCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCL 266

  Fly   263 LEVDALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVSFRV 327
            |:.|.|..:|:|||||||||.|.:.::||||||||:||:|||: |...||||||.||.|..||.|
Mouse   267 LDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQF-NHETRWTFHPGALTKHNSFWV 330

  Fly   328 GDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPKCVK 392
            ||:|.:|.|.:.|::||.|||||.:.|..|||::.|||||:.||:||:..  .|..||.:|.|
Mouse   331 GDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAV--GGQRWTFSPSC-- 391

  Fly   393 LERSPLATAAERSNSMMDLSHRRADH----VMTPLSGLSGS--------------SVA-DK---- 434
                 |.......::.:|::.|..::    .::...|..||              ||| ||
Mouse   392 -----LVAYRPEEDANLDVAERARENKSAASVSVAGGRQGSPWPALTSTLPPGSLSVALDKLRTQ 451

  Fly   435 ---------LVREAAQGH----LDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISK 486
                     ||.|||.|:    ||.:|::    |.|||..:.|:..:|||::.|.|:||..|:..
Mouse   452 KSDPEHPGRLVVEAALGNVARALDLLRRH----PEQVDTKNQGRTALQVAAYLGQVELVRLLLQA 512

  Fly   487 GANVNAVDKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQ 551
            .|:::..|.||::.|||.|.||||...||||..|..|:..|.:..:|||:...:.....|:.|.:
Mouse   513 RASMDLPDDEGNTVLHYTAMGNQPEATRVLLSAGCAVDARNGTRSTALHVAVQRGFLEVVKILCE 577

  Fly   552 HNANVNIQDSYGDTALHDAI--GKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAAR 614
            ...:||:.|::.||.||.||  |...:.:||:|...|.:|.|..|::||.:||||:|||:|:|.|
Mouse   578 RGCDVNLPDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVR 642

  Fly   615 RILLLSRQLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAG 679
            :||..:||||:.:|:|||.||||||||.|.:|.:.|:.||:.::::||.:.|:|..|||.|.|.|
Mouse   643 KILARARQLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLG 707

  Fly   680 VIERLVRLSCDVNAKDEDGDNAMHLCVIKKSNL-----QSAAEPQPEEAPEIHKFYLSLVHSSIR 739
            ::..||...|.||.:||:||.|:|:.:.:...|     ::..:|.|.:       .||.:.:|..
Mouse   708 LVPLLVDAGCSVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQ-------LLSRLQASGL 765

  Fly   740 PEDRLMYSILIYLSRAGCRVELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGS 804
            |.    .:.|...:...|.:.|..|:.|   :...|....|....:|      |.|:||
Mouse   766 PG----CTELTVGAAVACFLALEGADVS---YANHRGRSPLDLATEG------RVLKAL------ 811

  Fly   805 ADGEESSASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNS 869
                :..|....|....|.|.|  ||.|:    .::..||.:..:.|
Mouse   812 ----QGCAQRFRERQAGGGGGV--PPGPR----HVLSTPNTVTNLHV------------------ 848

  Fly   870 DATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNEILPMVRFEP 934
                                            :|.|||..:        ||:||:|:..::.|.|
Mouse   849 --------------------------------SGTAGPEAA--------ECLVCSELALLILFSP 873

  Fly   935 CQHQIACEECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLE 999
            |||:..||||..|||||:||.|.|.::|...|..|.  .:...|..|.:     |:..|:::..:
Mouse   874 CQHRTVCEECARRMKKCIRCQVVISKKLRPDGSEVV--NAIQVPGPPRQ-----LVEELQSRYRQ 931

  Fly  1000 FEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKINLY 1049
            .||...|.||::....:.|.||||||:.|...|..|.:||:.|..:|.::
Mouse   932 MEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIF 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184	40/64 (63%)
		ZZ_Mind_bomb	85..129	CDD:239079	18/43 (42%)
		MIB_HERC2	156..220	CDD:284184	46/63 (73%)
		ANK	464..582	CDD:238125	45/119 (38%)
		ANK repeat	464..494	CDD:293786	10/29 (34%)
		Ank_2	468..560	CDD:289560	34/91 (37%)
		ANK repeat	496..527	CDD:293786	16/30 (53%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		Ank_5	549..604	CDD:290568	22/56 (39%)
		ANK	557..685	CDD:238125	61/129 (47%)
		ANK repeat	596..628	CDD:293786	18/31 (58%)
		Ank_2	601..695	CDD:289560	48/93 (52%)
		ANK repeat	630..662	CDD:293786	16/31 (52%)
		ANK repeat	664..695	CDD:293786	13/30 (43%)
		zf-C3HC4_3	918..961	CDD:290631	23/42 (55%)
		zf-C3HC4_3	1002..1044	CDD:290631	17/41 (41%)
Mib2	XP_006539310.1	MIB_HERC2	12..77	CDD:369043	40/64 (63%)
		ZZ_Mind_bomb	89..133	CDD:239079	18/43 (42%)
		MIB_HERC2	160..224	CDD:369043	46/63 (73%)
		SH3_15	257..322	CDD:375773	39/65 (60%)
		SH3_15	328..392	CDD:375773	33/72 (46%)
		PLN03192	<453..517	CDD:215625	23/67 (34%)
		PHA03095	486..>737	CDD:222980	106/250 (42%)
		ANK repeat	490..520	CDD:293786	10/29 (34%)
		ANK repeat	522..553	CDD:293786	16/30 (53%)
		ANK repeat	555..586	CDD:293786	7/30 (23%)
		ANK repeat	588..622	CDD:293786	13/33 (39%)
		ANK repeat	625..656	CDD:293786	18/30 (60%)
		ANK repeat	658..690	CDD:293786	16/31 (52%)
		ANK repeat	692..723	CDD:293786	13/30 (43%)
		RING1-HC_MIB2	858..894	CDD:319640	20/35 (57%)
		RING_Ubox	937..982	CDD:388418	17/45 (38%)
		RING-HC finger (C3HC4-type)	938..970	CDD:319361	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834069
Domainoid	1	1.000	109	1.000	Domainoid score	I6383
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16062
Inparanoid	1	1.050	675	1.000	Inparanoid score	I724
Isobase	1	0.950	-	0	Normalized mean entropy	S6907
OMA	1	1.010	-	-		QHG47157
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	1	1.000	-	-		oto94560
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	1	1.100	-	-	LDO	PTHR24202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13065
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740