DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and mib2

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001073146.1	Gene:	mib2 / 560887	ZFINID:	ZDB-GENE-050628-1	Length:	999	Species:	Danio rerio

Alignment Length:	1079	Identity:	465/1079 - (43%)
Similarity:	637/1079 - (59%)	Gaps:	162/1079 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQN 66
            |.|:..|:|||||.:|.|:||||||||||||.||||.|||.:|:.||||.||||.|||||.|||.
Zfish    51 RGSMEVGMRVVRGADWKWANQDDGEGHVGTVVEIGRQGSTTTPDKTVVVQWDSGTRTNYRSGYQG 115

  Fly    67 QYDLIIVDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTT 131
            .:||::.||||:||||||::||.|.|.||.|:.:||..|.:|.||..||..:.|.:.|.|.||.|
Zfish   116 AFDLLLYDNAQIGVRHSNIICDSCKKHGIMGMRWKCKVCFDYDLCTQCYMNNKHGLTHAFERYET 180

  Fly   132 PNSLGVRLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVAN 196
            .:|..|.|..|:...||.|:|||.|.||||||||:|..||||||:.|:|::|||||.||.||||:
Zfish   181 AHSQPVSLTPRQNLSRIILKGIFQGVKVVRGPDWDWGNQDGGEGKVGKVVDIRGWDQESGRSVAS 245

  Fly   197 VAWVTGSTNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKV 261
            |.|...:|||||:||||.|||||::...||.|||:|:|.||:..|||........||..||:||.
Zfish   246 VTWSNSTTNVYRMGHKGKVDLKYVSDVQGGFYYKEHLPKLGEHAELQRQESADSHSFQQGDKVKC 310

  Fly   262 CLEVDALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPN-RWTFHPAALVKVVSF 325
            .||||.|.::|:|||||||:|.|::|::||||||||:||:||||.|  | ||||||.||.||.:|
Zfish   311 LLEVDILRQMQEGHGGWNPKMAEYISRIGTVHRITDRGDVRVQYSN--NIRWTFHPGALTKVNTF 373

  Fly   326 RVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPKC 390
            .||:||.:::|.:.|::||.|||||.:.|..|||::.||:|||:|||||:  ...|..||.||.|
Zfish   374 AVGELVKVLDDIDSVKRLQVGHGEWTDSMAPALGQVGKVLKVYADGDLRV--AFGGQTWTFNPAC 436

  Fly   391 VKLERS-------PLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVAD---KLVREAAQGHLD 445
            :..:..       .:..|:|.|::::.:..:.          ||.|:..|   :||.|||.|...
Zfish   437 LSAQPGEVDANLMTVENASESSSTVISVLEKL----------LSQSTEQDNPGRLVIEAAHGSAA 491

  Fly   446 FVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDKEGDSALHYAAFGNQP 510
            .||:.|..:|.:||:.:.||..:|||:|||:|::|..|:...:::.|.|::||:||||.|||||.
Zfish   492 KVRELLQKHPDKVDIKNQGKTALQVAAHQGHVEVVKVLLQANSSIEAKDEDGDAALHYTAFGNQA 556

  Fly   511 ATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQDSYGDTALHDAIGKEN 575
            ...|:||..||.||.||:|.|:||||..:|.....||.|.:|:|:||:|||||||.|||||.|:.
Zfish   557 EIARLLLSKGASVNLLNNSMCTALHIAVNKGFTDVVRVLTEHSADVNLQDSYGDTPLHDAIAKDF 621

  Fly   576 TEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQLVNVRKDDGFAALHLAAL 640
            ..::|:|...||:|||.:||||||:|||||||||.:|...||..:|||.:|:|:|||:|||||||
Zfish   622 RSIIEILTVVPNIDFTQQNNRGFNLLHHAALKGNKLATEMILSRARQLADVKKEDGFSALHLAAL 686

  Fly   641 NGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDEDGDNAMHLC 705
            |.|..|.|.|:.||:.:::|||||.|||..|||:|||..::..||....||||:|||||.|||..
Zfish   687 NNHRDVAEILLKEGRCDINIRNNRNQTPLQLAVTQGHMALVALLVMEGADVNAEDEDGDTAMHTS 751

  Fly   706 VIKKSNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMY------------------SILIYL 752
            :.::.                    |:.|.||...:..::|                  :|..:|
Zfish   752 LSRQQ--------------------LTTVISSAEGDGAVLYGRLCSSGLMGNTELNVGAAIACFL 796

  Fly   753 SRAGCRVE-LNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEESSASAGA 816
            ::.|..:. .|:...|..:.:||..::.||   :..||.  ..|.|:....||:
Zfish   797 AQEGADISYANHKGKSPLDLVTDSSVQTLI---RSFAEK--HRLHAVSCGTGSS----------- 845

  Fly   817 ESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNVSPQVA 881
                                                      |:|..:::::
Zfish   846 ------------------------------------------SSSSSLRRVH------------- 855

  Fly   882 PRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNEILPMVRFEPCQHQIACEECGI 946
                      ||.::.|.|    |.||     |.||.||::|:|:..:|.|.||||.:|||||..
Zfish   856 ----------TTPNTMTNL----AVPS-----VTGPSECLICSELALLVLFSPCQHSVACEECAH 901

  Fly   947 RMKKCLRCAVAIERRLTV-SGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLEFEESHFCGICM 1010
            |||||:||.|.|.:::.. ...|...|:|.:|...       .||..|:::..:.||...|.||:
Zfish   902 RMKKCIRCQVTITKKIRQDQTEVECSPSSENSEQH-------HLLEQLQSRYRQMEERITCPICI 959

  Fly  1011 ERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKINLY 1049
            :....:.|.|||.:|..|:..|:||.:||:||.::|.|:
Zfish   960 DNHIRLVFQCGHASCIDCSSALKTCPICRQTIRERIQLF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184	46/64 (72%)
		ZZ_Mind_bomb	85..129	CDD:239079	18/43 (42%)
		MIB_HERC2	156..220	CDD:284184	44/63 (70%)
		ANK	464..582	CDD:238125	61/117 (52%)
		ANK repeat	464..494	CDD:293786	12/29 (41%)
		Ank_2	468..560	CDD:289560	45/91 (49%)
		ANK repeat	496..527	CDD:293786	18/30 (60%)
		ANK repeat	529..560	CDD:293786	14/30 (47%)
		Ank_5	549..604	CDD:290568	33/54 (61%)
		ANK	557..685	CDD:238125	75/127 (59%)
		ANK repeat	596..628	CDD:293786	20/31 (65%)
		Ank_2	601..695	CDD:289560	54/93 (58%)
		ANK repeat	630..662	CDD:293786	18/31 (58%)
		ANK repeat	664..695	CDD:293786	16/30 (53%)
		zf-C3HC4_3	918..961	CDD:290631	24/42 (57%)
		zf-C3HC4_3	1002..1044	CDD:290631	17/41 (41%)
mib2	NP_001073146.1	MIB_HERC2	57..122	CDD:284184	46/64 (72%)
		ZZ_Mind_bomb	134..178	CDD:239079	18/43 (42%)
		MIB_HERC2	205..269	CDD:284184	44/63 (70%)
		ANK repeat	481..508	CDD:293786	11/29 (38%)
		Ank_4	485..530	CDD:290365	20/44 (45%)
		ANK	508..628	CDD:238125	61/119 (51%)
		ANK repeat	510..540	CDD:293786	11/29 (38%)
		Ank_2	514..606	CDD:289560	44/91 (48%)
		ANK repeat	542..573	CDD:293786	17/30 (57%)
		ANK	570..731	CDD:238125	93/160 (58%)
		ANK repeat	575..606	CDD:293786	14/30 (47%)
		Ank_5	595..650	CDD:290568	33/54 (61%)
		ANK repeat	642..674	CDD:293786	21/31 (68%)
		Ank_2	647..741	CDD:289560	53/93 (57%)
		ANK	671..816	CDD:238125	58/163 (36%)
		ANK repeat	676..708	CDD:293786	18/31 (58%)
		ANK repeat	710..741	CDD:293786	16/30 (53%)
		Ank_2	715..807	CDD:289560	31/109 (28%)
		zf-C3HC4_3	874..915	CDD:290631	2/40 (5%)
		zf-C3HC4_3	951..994	CDD:290631	20/42 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16062
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47157
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	1	1.100	-	-	LDO	PTHR24202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.930