Protein Alignment mib2 and Mib2

DIOPT Version :10

• Sequence 1: NP_609933.1
• Gene: mib2 / 35170
• FlyBaseID: FBgn0086442
• Length: 1049
• Species: Drosophila melanogaster
• Sequence 2: XP_017449042.1
• Gene: Mib2 / 474147
• RGDID: 1359469
• Length: 982
• Species: Rattus norvegicus
• Alignment Length: 1083
• Identity: 434/1083 - (40%)
• Similarity: 603/1083 - (55%)
• Gaps: 144/1083 - (13%)

  Fly     3 ASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQ 67
            |.:..|:|||||.:|.|..||.|||.||||.|:||.||..:|:.||||.||.|.|||||.|||..
  Rat     7 AGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGA 71

  Fly    68 YDLIIVDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTP 132
            :||::.||||:|:||.|::||.|.|.|:.|:.:||..|.:|.||..||..:.||:.|.|.||.|.
  Rat    72 HDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETS 136

  Fly   133 NSLGVRLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANV 197
            :|..|.|..|:|..||.|||||.|:||||||||||..||||||:||||::|||||.|:.||||:|
  Rat   137 HSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASV 201

  Fly   198 AWVTGSTNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVC 262
            .|..|:|||||:||||.||||.:....||.|||:|:|.||:..|||.........|..||:||..
  Rat   202 TWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCL 266

  Fly   263 LEVDALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVSFRV 327
            |:.|.|..:|:|||||||||.|.:.::||||||||:||:|||: |...||||||.||.|..||.|
  Rat   267 LDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQF-NHETRWTFHPGALTKHNSFWV 330

  Fly   328 GDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPKCV- 391
            ||:|.:|:|.:.|::||.|||||.:.|..|||::.|||||:.||:||:..  .|..||.:|.|:
  Rat   331 GDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAV--GGQRWTFSPACLV 393

  Fly   392 --KLERSPLATAAERSNSMMDLS--------HRRADHVMTPLSGLSGSSVA-DK----------- 434
              :.|.......|||:......:        ..|....:||.......||| ||
  Rat   394 ACRPEEDANLGVAERARENKSAASVPVAGGRQGRPWPALTPTLPPGSLSVALDKLRTQKSDPEHP 458

  Fly   435 --LVREAAQGH----LDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAV 493
              ||.|||.|:    ||.:|::    |.|||..:.|:..:|||::.|.|:||..|:...|:|:.:
  Rat   459 GRLVVEAALGNVARALDLLRRH----PEQVDTKNQGRTALQVAAYLGQVELVRLLLQARASVDLL 519

  Fly   494 DKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNI 558
            |:||::||||.|.||||...|:||..|..|:..|.:..:|||:...:.....|:.|.:|..:||:
  Rat   520 DEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLEVVKILCEHGCDVNL 584

  Fly   559 QDSYGDTALHDAI--GKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSR 621
            .|::.||.||.||  |...:.:||:|...|.:|.|..|::||.:||||:|||:|:|.|:||..:|
  Rat   585 PDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARAR 649

  Fly   622 QLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVR 686
            |||:.:|:|||.||||||||.|.:|.:.|:.||:.::::||.:.|:|..|||.|.|.|::..||.
  Rat   650 QLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVD 714

  Fly   687 LSCDVNAKDEDGDNAMHLCVIKKSNL-----QSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMY 746
            ..|:||.:||:||.|:|:.:.:...|     ::..:|.|.:       .||.:.:|..|..
  Rat   715 AGCNVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQ-------LLSRLQASGLPGS---- 768

  Fly   747 SILIYLSRAGCRVELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEESS 811
            :.|...:...|.:.|..|:.|   :...|....|....:|      |.|:||          :..
  Rat   769 TELTVGAAVACFLALEGADVS---YANHRGRSPLDLATEG------RVLKAL----------QGC 814

  Fly   812 ASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNV 876
            |....|....|.|.|  ||.|:    .::..||.:..:.|
  Rat   815 AQRFRERQAGGGGGV--PPGPR----HVLSTPNTVTNLHV------------------------- 848

  Fly   877 SPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNEILPMVRFEPCQHQIAC 941
                                     :|.|||..:        ||:||:|:..:|.|.||||:..|
  Rat   849 -------------------------SGTAGPEAA--------ECLVCSELALLVLFSPCQHRTVC 880

  Fly   942 EECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLEFEESHFC 1006
            |||..|||||:||.|.|.::|...|..|.  .:...|..|.:     |:..|:::..:.||...|
  Rat   881 EECARRMKKCIRCQVIISKKLRPDGSEVV--NAIQVPGPPRQ-----LVEELQSRYRQMEERITC 938

  Fly  1007 GICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKINLY 1049
            .||::....:.|.||||||:.|...|..|.:||:.|..:|.::
  Rat   939 PICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIF 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_609933.1	MIB_HERC2	8..74	CDD:461991	40/65 (62%)
		ZZ_Mind_bomb	85..129	CDD:239079	18/43 (42%)
		MIB_HERC2	156..220	CDD:461991	47/63 (75%)
		SH3_15	253..319	CDD:465720	39/65 (60%)
		SH3_15	325..391	CDD:465720	32/65 (49%)
		ANKYR	398..664	CDD:440430	113/293 (39%)
		ANK repeat	464..494	CDD:293786	11/29 (38%)
		ANK repeat	496..527	CDD:293786	16/30 (53%)
		ANK repeat	529..560	CDD:293786	8/30 (27%)
		ANK repeat	596..628	CDD:293786	18/31 (58%)
		ANK repeat	630..662	CDD:293786	16/31 (52%)
		Ank_5	650..705	CDD:433530	24/54 (44%)
		ANK repeat	664..695	CDD:293786	13/30 (43%)
		PRK14959	<791..>919	CDD:184923	19/127 (15%)
		RING-HC_MIB2_rpt1	918..955	CDD:438386	21/36 (58%)
		RING-HC_MIBs-like	1004..1042	CDD:438183	15/37 (41%)
Mib2	XP_017449042.1	MIB_HERC2	12..78	CDD:461991	40/65 (62%)
		ZZ_Mind_bomb	89..133	CDD:239079	18/43 (42%)
		MIB_HERC2	160..224	CDD:461991	47/63 (75%)
		SH3_15	257..322	CDD:465720	39/65 (60%)
		SH3_15	328..392	CDD:465720	32/65 (49%)
		ANKYR	443..693	CDD:440430	106/253 (42%)
		ANK repeat	490..520	CDD:293786	11/29 (38%)
		ANK repeat	522..553	CDD:293786	16/30 (53%)
		ANK repeat	555..586	CDD:293786	8/30 (27%)
		ANK repeat	588..622	CDD:293786	13/33 (39%)
		ANK repeat	625..656	CDD:293786	18/30 (60%)
		ANK repeat	658..690	CDD:293786	16/31 (52%)
		Ank_2	663..739	CDD:463710	33/75 (44%)
		ANK repeat	692..723	CDD:293786	13/30 (43%)
		RING-HC_MIB2_rpt1	857..894	CDD:438386	21/44 (48%)
		RING_Ubox	932..982	CDD:473075	19/50 (38%)