DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and Mib2

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_006239651.1	Gene:	Mib2 / 474147	RGDID:	1359469	Length:	982	Species:	Rattus norvegicus

Alignment Length:	1083	Identity:	434/1083 - (40%)
Similarity:	603/1083 - (55%)	Gaps:	144/1083 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQ 67
            |.:..|:|||||.:|.|..||.|||.||||.|:||.||..:|:.||||.||.|.|||||.|||..
  Rat     7 AGVQVGMRVVRGMDWKWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGTRTNYRAGYQGA 71

  Fly    68 YDLIIVDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTP 132
            :||::.||||:|:||.|::||.|.|.|:.|:.:||..|.:|.||..||..:.||:.|.|.||.|.
  Rat    72 HDLLLYDNAQIGIRHPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETS 136

  Fly   133 NSLGVRLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANV 197
            :|..|.|..|:|..||.|||||.|:||||||||||..||||||:||||::|||||.|:.||||:|
  Rat   137 HSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASV 201

  Fly   198 AWVTGSTNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVC 262
            .|..|:|||||:||||.||||.:....||.|||:|:|.||:..|||.........|..||:||..
  Rat   202 TWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSADGQPFQRGDKVKCL 266

  Fly   263 LEVDALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVSFRV 327
            |:.|.|..:|:|||||||||.|.:.::||||||||:||:|||: |...||||||.||.|..||.|
  Rat   267 LDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRITDRGDVRVQF-NHETRWTFHPGALTKHNSFWV 330

  Fly   328 GDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPKCV- 391
            ||:|.:|:|.:.|::||.|||||.:.|..|||::.|||||:.||:||:..  .|..||.:|.|:
  Rat   331 GDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAV--GGQRWTFSPACLV 393

  Fly   392 --KLERSPLATAAERSNSMMDLS--------HRRADHVMTPLSGLSGSSVA-DK----------- 434
              :.|.......|||:......:        ..|....:||.......||| ||
  Rat   394 ACRPEEDANLGVAERARENKSAASVPVAGGRQGRPWPALTPTLPPGSLSVALDKLRTQKSDPEHP 458

  Fly   435 --LVREAAQGH----LDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAV 493
              ||.|||.|:    ||.:|::    |.|||..:.|:..:|||::.|.|:||..|:...|:|:.:
  Rat   459 GRLVVEAALGNVARALDLLRRH----PEQVDTKNQGRTALQVAAYLGQVELVRLLLQARASVDLL 519

  Fly   494 DKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNI 558
            |:||::||||.|.||||...|:||..|..|:..|.:..:|||:...:.....|:.|.:|..:||:
  Rat   520 DEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRSTALHVAVQRGFLEVVKILCEHGCDVNL 584

  Fly   559 QDSYGDTALHDAI--GKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSR 621
            .|::.||.||.||  |...:.:||:|...|.:|.|..|::||.:||||:|||:|:|.|:||..:|
  Rat   585 PDAHADTPLHSAISAGAGASSIVEVLTEVPGIDVTATNSQGFTLLHHASLKGHVLAVRKILARAR 649

  Fly   622 QLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVR 686
            |||:.:|:|||.||||||||.|.:|.:.|:.||:.::::||.:.|:|..|||.|.|.|::..||.
  Rat   650 QLVDAKKEDGFTALHLAALNNHREVAQVLIREGRCDVNVRNRKLQSPLHLAVQQAHLGLVPLLVD 714

  Fly   687 LSCDVNAKDEDGDNAMHLCVIKKSNL-----QSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMY 746
            ..|:||.:||:||.|:|:.:.:...|     ::..:|.|.:       .||.:.:|..|..
  Rat   715 AGCNVNTEDEEGDTALHVALQRHQLLPLVADRAGGDPGPLQ-------LLSRLQASGLPGS---- 768

  Fly   747 SILIYLSRAGCRVELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEESS 811
            :.|...:...|.:.|..|:.|   :...|....|....:|      |.|:||          :..
  Rat   769 TELTVGAAVACFLALEGADVS---YANHRGRSPLDLATEG------RVLKAL----------QGC 814

  Fly   812 ASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNV 876
            |....|....|.|.|  ||.|:    .::..||.:..:.|
  Rat   815 AQRFRERQAGGGGGV--PPGPR----HVLSTPNTVTNLHV------------------------- 848

  Fly   877 SPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNEILPMVRFEPCQHQIAC 941
                                     :|.|||..:        ||:||:|:..:|.|.||||:..|
  Rat   849 -------------------------SGTAGPEAA--------ECLVCSELALLVLFSPCQHRTVC 880

  Fly   942 EECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLEFEESHFC 1006
            |||..|||||:||.|.|.::|...|..|.  .:...|..|.:     |:..|:::..:.||...|
  Rat   881 EECARRMKKCIRCQVIISKKLRPDGSEVV--NAIQVPGPPRQ-----LVEELQSRYRQMEERITC 938

  Fly  1007 GICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKINLY 1049
            .||::....:.|.||||||:.|...|..|.:||:.|..:|.::
  Rat   939 PICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDRIQIF 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184	40/64 (63%)
		ZZ_Mind_bomb	85..129	CDD:239079	18/43 (42%)
		MIB_HERC2	156..220	CDD:284184	47/63 (75%)
		ANK	464..582	CDD:238125	47/119 (39%)
		ANK repeat	464..494	CDD:293786	11/29 (38%)
		Ank_2	468..560	CDD:289560	36/91 (40%)
		ANK repeat	496..527	CDD:293786	16/30 (53%)
		ANK repeat	529..560	CDD:293786	8/30 (27%)
		Ank_5	549..604	CDD:290568	23/56 (41%)
		ANK	557..685	CDD:238125	61/129 (47%)
		ANK repeat	596..628	CDD:293786	18/31 (58%)
		Ank_2	601..695	CDD:289560	48/93 (52%)
		ANK repeat	630..662	CDD:293786	16/31 (52%)
		ANK repeat	664..695	CDD:293786	13/30 (43%)
		zf-C3HC4_3	918..961	CDD:290631	24/42 (57%)
		zf-C3HC4_3	1002..1044	CDD:290631	17/41 (41%)
Mib2	XP_006239651.1	MIB_HERC2	12..78	CDD:399589	40/65 (62%)
		ZZ_Mind_bomb	89..133	CDD:239079	18/43 (42%)
		MIB_HERC2	160..224	CDD:399589	47/63 (75%)
		SH3_15	257..322	CDD:408152	39/65 (60%)
		SH3_15	328..392	CDD:408152	32/65 (49%)
		PLN03192	<453..517	CDD:215625	23/67 (34%)
		PHA03095	486..>737	CDD:222980	108/250 (43%)
		ANK repeat	490..520	CDD:293786	11/29 (38%)
		ANK repeat	522..553	CDD:293786	16/30 (53%)
		ANK repeat	555..586	CDD:293786	8/30 (27%)
		ANK repeat	588..622	CDD:293786	13/33 (39%)
		ANK repeat	625..656	CDD:293786	18/30 (60%)
		ANK repeat	658..690	CDD:293786	16/31 (52%)
		ANK repeat	692..723	CDD:293786	13/30 (43%)
		RING1-HC_MIB2	858..894	CDD:319640	21/35 (60%)
		RING_Ubox	937..982	CDD:418438	17/45 (38%)
		RING-HC finger (C3HC4-type)	938..970	CDD:319361	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337608
Domainoid	1	1.000	110	1.000	Domainoid score	I6197
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16062
Inparanoid	1	1.050	695	1.000	Inparanoid score	I654
OMA	1	1.010	-	-		QHG47157
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	1	1.000	-	-		oto98072
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	1	1.100	-	-	LDO	PTHR24202
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770