DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mib2 and sqstm1

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001299842.1	Gene:	sqstm1 / 406452	ZFINID:	ZDB-GENE-040426-2204	Length:	452	Species:	Danio rerio

Alignment Length:	429	Identity:	96/429 - (22%)
Similarity:	144/429 - (33%)	Gaps:	149/429 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 HSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKGAK 146
            |..|.||||. ..:||..:||..||:|.||..|.::.||. ||..:....|
Zfish   145 HPGVTCDGCD-GPVAGTRYKCTVCPDYDLCPTCQSKGLHK-EHALLPIFHP-------------- 193

  Fly   147 RIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRLGH 211
               :..:|           ||..:    |:..|.|....|.|...:          :.|..:.|.
Zfish   194 ---MANVF-----------EWLPR----GKFWRKMRHCMWANAQAQ----------AQNQPQPGP 230

  Fly   212 KG---NVDL----KYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVCLEVDALM 269
            .|   |.|.    ....||.......:::..:|     :.||.|:.|           |.:|.
Zfish   231 SGAQQNQDAPENPNENGATASSQANVEYLKNIG-----EEVAAMLSP-----------LGIDV-- 277

  Fly   270 KLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVSFRVGDLVTII 334
                                          ||.|::|....:.|..|.|.....|.|
Zfish   278 ------------------------------DIDVEHEGKRTKVTPTPPASSGPSSAR-------- 304

  Fly   335 NDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWT-LNPKCVKLERSPL 398
            :|:..|..|.:|.|...:....::          |:|..:.|..|:  ||| |:.|.|......|
Zfish   305 SDSGSVGLLSRGSGPGSQATEESV----------SEGTKKDQCSDE--EWTHLSAKEVDPSTGEL 357

  Fly   399 ATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVAD--KLVREAA-QGHLDFVRQYLDVNPSQVDV 460
            .:        :.|....|| :..||:..||:|..|  ..:|||| ..||.     .|.:|..|:.
Zfish   358 QS--------LRLEQDGAD-LPAPLNTASGTSTRDGPTGLREAALYPHLP-----QDADPRLVES 408

  Fly   461 MSGGKACIQVASHQGYVD----LVSYLISKGANV-NAVD 494
            :|      |:.| .|:.|    |...|.:|..:: .|:|
Zfish   409 LS------QMLS-MGFTDEGGWLTRLLHTKNYDIGGALD 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184
		ZZ_Mind_bomb	85..129	CDD:239079	19/43 (44%)
		MIB_HERC2	156..220	CDD:284184	12/70 (17%)
		ANK	464..582	CDD:238125	9/36 (25%)
		ANK repeat	464..494	CDD:293786	8/34 (24%)
		Ank_2	468..560	CDD:289560	9/32 (28%)
		ANK repeat	496..527	CDD:293786
		ANK repeat	529..560	CDD:293786
		Ank_5	549..604	CDD:290568
		ANK	557..685	CDD:238125
		ANK repeat	596..628	CDD:293786
		Ank_2	601..695	CDD:289560
		ANK repeat	630..662	CDD:293786
		ANK repeat	664..695	CDD:293786
		zf-C3HC4_3	918..961	CDD:290631
		zf-C3HC4_3	1002..1044	CDD:290631
sqstm1	NP_001299842.1	PB1_p62	3..88	CDD:99723
		ZZ_NBR1_like	148..190	CDD:239080	19/43 (44%)
		UBA_like_SF	390..448	CDD:304366	18/63 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900