DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and mib1

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_648826.2	Gene:	mib1 / 39750	FlyBaseID:	FBgn0263601	Length:	1226	Species:	Drosophila melanogaster

Alignment Length:	1188	Identity:	395/1188 - (33%)
Similarity:	571/1188 - (48%)	Gaps:	216/1188 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLII 72
            |.||:|||:|.|:.||.||||||||      .:..|.|..||| ||:|...|||..  ..|||.|
  Fly   109 GARVIRGPDWKWNKQDGGEGHVGTV------RNFESAEEVVVV-WDNGTAANYRCA--GAYDLRI 164

  Fly    73 VDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGV 137
            :|:|..||:|...:||.|.:..|.||.:|||:|.||.||:.||..|.|.:.|.|.|.|||.....
  Fly   165 LDSAPTGVKHEGTMCDTCRQQPIFGIRWKCAECINYDLCSICYHGDKHHLRHRFYRITTPGGERT 229

  Fly   138 RLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTG 202
            .|..|:.:|::..||||.|::||||.||:|.:||||.||.|:|.||:.|.:.|.||.|.|.|..|
  Fly   230 MLEPRRKSKKVLARGIFPGARVVRGVDWQWEDQDGGVGRRGKVNEIQDWSSASPRSAAYVIWDNG 294

  Fly   203 STNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKP-SFSVGDRVKVCLEVD 266
            |.|:||:|.:|..|||.:....|.:.|:||:|:||:.      .|...| .|.:||:|.|.|:::
  Fly   295 SKNLYRVGFEGMADLKVVNDAKGSNVYRDHLPLLGEN------GPGKGPHGFQIGDKVTVDLDLE 353

  Fly   267 ALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVS------- 324
            .:..||.|||||...|.|.||..|.|..|.:..||.|.| |..|||||:||.|.||.|
  Fly   354 IVQSLQHGHGGWTDGMFECLSNAGMVVGIDEDHDIVVAY-NSGNRWTFNPAVLTKVSSPTTAPPE 417

  Fly   325 FRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPK 389
            |:|||:|.|.:|...::.||:|||||.:.|:..||||.:|.:||.|.||:::.  ....||.||.
  Fly   418 FQVGDIVKICSDVESIKILQRGHGEWADAMQLTLGKIGRVQQVYHDNDLKVEV--GNTSWTYNPL 480

  Fly   390 CV-KLERSPLATAAERSNSMMDLSHRRADHVMTPL--SGLSGSSVADKLVREAAQGHLDFVRQYL 451
            .| |:..|   ||::.|.:.:..|..|...::..|  ..:||.: .::.|:.||.|......:||
  Fly   481 AVCKVASS---TASDGSCAPVIPSSERLSAILKKLFEPNVSGDA-TEEFVKAAANGFAARCEEYL 541

  Fly   452 -----------------DVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDKEGDS 499
                             |||   |:.:..|...:|.||..|:::::..|:....:|...||:||.
  Fly   542 AGAAQPSTSSASPSSGPDVN---VNGVFAGHTALQAASQNGHIEVIQVLLRHAVDVEIEDKDGDR 603

  Fly   500 ALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQDSYGD 564
            |:|:||||::.|.:.:|.:.||::|..|....::|||..:|...:.|:.||....:.::|||.||
  Fly   604 AVHHAAFGDEAAVIEILAKAGADLNARNKRRQTSLHIAVNKGHLNVVKTLLTLGCHPSLQDSEGD 668

  Fly   565 TALHDAIGKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQ---LVNV 626
            |.|||||.||:.|::.||.:. ..|.|:.||.|||.||||||||| .:|.:|||....   :|..
  Fly   669 TPLHDAISKEHDEMLSLLLDF-GADITLNNNNGFNALHHAALKGN-PSAMKILLTKTNRPWIVEE 731

  Fly   627 RKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDV 691
            :||||:.||||||||.|.::.|.||..|:|.:|.:|...||...|||.:.|..:::.||:...|:
  Fly   732 KKDDGYTALHLAALNNHVEIAELLVHMGKANMDRQNVNLQTALHLAVERQHVQIVKLLVQDGADL 796

  Fly   692 NAKDEDGDNAMHLCVIKKSNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSILIYLSRAG 756
            |..|:|||..:|. .::...|....:.|..|.  ..|..:.|.:::   ..:...||..:|:..|
  Fly   797 NIPDKDGDTPLHE-ALRHHTLSQLKQLQDVEG--FGKLLMGLRNAN---NKKASASIACFLAANG 855

  Fly   757 CRVELNNANASI-FEWITDRHIRQLIFGQQGEAES----LPRNLQALEVSAGSADGEESSASAGA 816
            ..:.|.|..... .:...|.::.:.:.....|.::    ||          |:..|..|||.|.|
  Fly   856 ADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELP----------GNVAGTSSSARARA 910

  Fly   817 ESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSA-SPGVKKLNSDATPQNVSPQV 880
            .|......|..                 ::|...:.||.:.|:| |..:..||..|...:.|..
  Fly   911 ASGSLNQSSSV-----------------NMPLSSLAASSTFPAASSSSIFALNGIANEMSQSLH- 957

  Fly   881 APRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPH--------------------------- 918
                  ..||.:::|....|....|...|  |..|..|
  Fly   958 ------EDPPKSSASLDECLVCSDAKRDT--VFKPCGHVSCCETCAPRVKKCLICRETVSSREKI 1014

  Fly   919 -ECIVCNEILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERRLT------------------- 963
             ||:||::....|.|.||.|.:|||.|...||||:.|...|:..|:
  Fly  1015 DECLVCSDRRAAVFFRPCGHMVACEHCSALMKKCVLCRTQIDEILSFSLCCGGSGRPEKVSVAAG 1079

  Fly   964 -------------------------VSGRVVAL------PTSTSS-------------------- 977
                                     .||..||:      |.:.||
  Fly  1080 AMATVGLPLPDDRFMEAAAAAACANASGHSVAMNNTVVTPVAGSSNQLNSQNNLLAAAAASSNVS 1144

  Fly   978 -----------PSDPTRLPSGDLLRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAET 1031
                       ||:.......|:.: |:.::.:.:|...|.:|.:|.:::.||||||.|..|.:.
  Fly  1145 NLSAAGNAMVAPSNVNNFQMDDVQK-LKQQLQDIKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQ 1208

  Fly  1032 LRTCHMCRKTILKKINLY 1049
            :..|.:||||:.|:|.|:
  Fly  1209 IEGCPICRKTVEKRILLF 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184	32/64 (50%)
		ZZ_Mind_bomb	85..129	CDD:239079	20/43 (47%)
		MIB_HERC2	156..220	CDD:284184	35/63 (56%)
		ANK	464..582	CDD:238125	44/117 (38%)
		ANK repeat	464..494	CDD:293786	7/29 (24%)
		Ank_2	468..560	CDD:289560	29/91 (32%)
		ANK repeat	496..527	CDD:293786	13/30 (43%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		Ank_5	549..604	CDD:290568	27/54 (50%)
		ANK	557..685	CDD:238125	63/130 (48%)
		ANK repeat	596..628	CDD:293786	17/34 (50%)
		Ank_2	601..695	CDD:289560	44/96 (46%)
		ANK repeat	630..662	CDD:293786	17/31 (55%)
		ANK repeat	664..695	CDD:293786	10/30 (33%)
		zf-C3HC4_3	918..961	CDD:290631	20/70 (29%)
		zf-C3HC4_3	1002..1044	CDD:290631	17/41 (41%)
mib1	NP_648826.2	MIB_HERC2	109..165	CDD:284184	32/64 (50%)
		ZZ_Mind_bomb	177..221	CDD:239079	20/43 (47%)
		MIB_HERC2	248..312	CDD:284184	35/63 (56%)
		Ank_4	568..620	CDD:290365	18/51 (35%)
		ANK repeat	568..598	CDD:293786	7/29 (24%)
		ANK repeat	600..631	CDD:293786	13/30 (43%)
		Ank_2	606..697	CDD:289560	36/91 (40%)
		ANK	628..756	CDD:238125	60/129 (47%)
		ANK repeat	633..664	CDD:293786	7/30 (23%)
		ANK repeat	666..695	CDD:293786	14/29 (48%)
		ANK repeat	699..733	CDD:293786	17/34 (50%)
		Ank_2	704..800	CDD:289560	44/96 (46%)
		ANK	734..872	CDD:238125	45/143 (31%)
		ANK repeat	735..767	CDD:293786	17/31 (55%)
		ANK repeat	769..800	CDD:293786	10/30 (33%)
		Ank_2	774..862	CDD:289560	23/93 (25%)
		ANK repeat	802..862	CDD:293786	14/65 (22%)
		zf-C3HC4_3	968..1011	CDD:290631	6/44 (14%)
		zf-C3HC4_3	1013..1058	CDD:290631	19/44 (43%)
		zf-C3HC4_3	1179..1222	CDD:290631	17/42 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I2180
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	1	1.100	-	-	P	PTHR24202
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
	9	8.800