DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and mib1

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_009295119.1	Gene:	mib1 / 352910	ZFINID:	ZDB-GENE-030404-2	Length:	1041	Species:	Danio rerio

Alignment Length:	1136	Identity:	391/1136 - (34%)
Similarity:	552/1136 - (48%)	Gaps:	203/1136 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLII 72
            |.||:|||:|.|..||.||||||||      .|..|||..||| ||:|...|||.  ...||:.|
Zfish    15 GARVIRGPDWKWGKQDGGEGHVGTV------RSFESPEEVVVV-WDNGTAANYRC--SGAYDVRI 70

  Fly    73 VDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGV 137
            :|:|..|::|...:||.|.:..|.||.:|||:|.||.||..||..|.|.:.|.|.|.|||.|..|
Zfish    71 LDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTTCYHGDKHHLRHRFYRITTPGSERV 135

  Fly   138 RLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTG 202
            .|..|:.:|:|..||||.|.:||||.||:|.:||||.||.|:|.||:.|...|..|.|.|.|..|
Zfish   136 LLESRRKSKKITARGIFAGGRVVRGVDWQWEDQDGGNGRRGKVTEIQDWSAASPHSAAYVLWDNG 200

  Fly   203 STNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLG-QTEELQPVAPMVKPSFSVGDRVKVCLEVD 266
            :.|:||:|.:|..|||.:....||.:|:||.|||| |.....|      ....:||.|.:.|:::
Zfish   201 AKNLYRVGFEGMSDLKCVQDAKGGTFYRDHCPVLGEQNGNRNP------GGLQIGDLVNIDLDLE 259

  Fly   267 ALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVK--VV------ 323
            .:..||.|||||...|.|.|:..|||..|.:..||.|||.: .|||||:||.|.|  ||
Zfish   260 IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS-GNRWTFNPAVLTKANVVRSGEVA 323

  Fly   324 --------SFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDD 380
                    .|.|||||.|..|.::::.||:|||||.|.|...|||:.:|.::|||.||:::..
Zfish   324 AGAEGGSSQFMVGDLVQICYDIDRIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVC-- 386

  Fly   381 GFEWTLNPKCVK----------------LERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGS 429
            |..||.||..|.                |..||...|...|..:..|..       |..||
Zfish   387 GTSWTYNPAAVTKVAPAGSAVTNASGAVLTESPSVPAERLSQLLKKLFE-------TQESG---- 440

  Fly   430 SVADKLVREAAQGHLDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVD 494
            .:.::||:.||.|.|..|...|......|:....|...:|.||..|:||::..|:....::.|.|
Zfish   441 DINEELVKAAANGDLAKVEDILKRPDVDVNGQCAGHTAMQAASQNGHVDVLKLLLKHSVDLEAED 505

  Fly   495 KEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQ 559
            |:||.|:|:|:||::.:.:.||.:.||::|..|....:.|||..:|.....|:.||....:.::|
Zfish   506 KDGDRAVHHASFGDEGSVIEVLHRGGADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQ 570

  Fly   560 DSYGDTALHDAIGKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSR--- 621
            ||.|||.|||||.|:..:::.:|..| ..|.|:.||.|||.||||||:||..|.|  :|||:
Zfish   571 DSEGDTPLHDAISKKRDDMLSVLLEA-GADVTITNNNGFNALHHAALRGNPSAMR--VLLSKLPR 632

  Fly   622 -QLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLV 685
             .:|:.:||||:.||||||||.|.:|.|.||.:|.|.||::|..|||...|||.:.|..::..||
Zfish   633 PWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDVQNVNQQTALHLAVERQHTQIVRLLV 697

  Fly   686 RLSCDVNAKDEDGDNAMH-------LCVIKK-SNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPED 742
            |....::.:|:|||..:|       |..::: .::|..::.:|.| |..:...:.|  .:...|.
Zfish   698 RAEAKLDVQDKDGDTPLHEALRHHTLSQLRQLQDMQDVSKVEPWE-PSKNTLIMGL--GTQGAEK 759

  Fly   743 RLMYSILIYLSRAGCRVELNN----------ANASIFEWITDRHIRQLIFGQQG-EAESLPRNLQ 796
            :...||..:|:..|..:.:.|          .:.|:.:.:...| ::...||.| .:.||..|.:
Zfish   760 KSAASIACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCH-KEKTSGQVGSRSPSLNSNNE 823

  Fly   797 ALEVSAGSADGEESSASAGAESNGAGP-GSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSA 860
            .||.....:|.:..:.        .|| |.:|        |..|                    .
Zfish   824 TLEECMVCSDMKRDTL--------FGPCGHIA--------TCSL--------------------C 852

  Fly   861 SPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNE 925
            ||.|||.      .....||..|.|.                               .||:||::
Zfish   853 SPRVKKC------LICKEQVQSRTKI-------------------------------EECVVCSD 880

  Fly   926 ILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERR--------------------LTVSGRVVA 970
            ....|.|:||.|..|||.|...||||::|...:|||                    ||.....:|
Zfish   881 KKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERRTPFVLCCGGKGMEDATDDEDLTGGSNSMA 945

  Fly   971 -----------LPTSTSSPSDPTRLPSGDL------LRYLENKVLEFEESHFCGICMERKRDVAF 1018
                       |..|.||.:.|......|.      ::.|:.::.:.:|...|.:|::|.:::.|
Zfish   946 GGSQDLLQPNNLALSWSSGNIPALQRDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIF 1010

  Fly  1019 LCGHGACSHCAETLRTCHMCRKTILKKINLY 1049
            :||||.|..|.:.:..|.:|||.|.::|.||
Zfish  1011 MCGHGTCQLCGDRMSECPICRKAIERRILLY 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184	33/64 (52%)
		ZZ_Mind_bomb	85..129	CDD:239079	20/43 (47%)
		MIB_HERC2	156..220	CDD:284184	33/63 (52%)
		ANK	464..582	CDD:238125	43/117 (37%)
		ANK repeat	464..494	CDD:293786	9/29 (31%)
		Ank_2	468..560	CDD:289560	30/91 (33%)
		ANK repeat	496..527	CDD:293786	12/30 (40%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		Ank_5	549..604	CDD:290568	25/54 (46%)
		ANK	557..685	CDD:238125	64/131 (49%)
		ANK repeat	596..628	CDD:293786	17/35 (49%)
		Ank_2	601..695	CDD:289560	46/97 (47%)
		ANK repeat	630..662	CDD:293786	19/31 (61%)
		ANK repeat	664..695	CDD:293786	10/30 (33%)
		zf-C3HC4_3	918..961	CDD:290631	19/42 (45%)
		zf-C3HC4_3	1002..1044	CDD:290631	16/41 (39%)
mib1	XP_009295119.1	MIB_HERC2	15..71	CDD:284184	33/64 (52%)
		ZZ_Mind_bomb	83..127	CDD:239079	20/43 (47%)
		MIB_HERC2	154..218	CDD:284184	33/63 (52%)
		Ank_2	446..571	CDD:289560	40/124 (32%)
		ANK repeat	475..538	CDD:293786	23/62 (37%)
		ANK	475..503	CDD:197603	8/27 (30%)
		ANK	535..663	CDD:238125	59/130 (45%)
		ANK repeat	540..571	CDD:293786	7/30 (23%)
		Ank_2	545..637	CDD:289560	41/94 (44%)
		ANK repeat	573..604	CDD:293786	13/31 (42%)
		ANK repeat	606..640	CDD:293786	17/35 (49%)
		Ank_2	611..707	CDD:289560	46/97 (47%)
		ANK	637..790	CDD:238125	49/155 (32%)
		ANK repeat	642..674	CDD:293786	19/31 (61%)
		ANK repeat	676..707	CDD:293786	10/30 (33%)
		Ank_2	681..780	CDD:289560	23/101 (23%)
		zf-C3HC4_3	826..869	CDD:290631	15/84 (18%)
		zf-C3HC4_3	871..916	CDD:290631	20/75 (27%)
		zf-C3HC4_3	994..1037	CDD:290631	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820