DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and Mib1

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_001100875.1	Gene:	Mib1 / 307594	RGDID:	1307195	Length:	1006	Species:	Rattus norvegicus

Alignment Length:	1114	Identity:	384/1114 - (34%)
Similarity:	546/1114 - (49%)	Gaps:	194/1114 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLII 72
            |.||||||:|.|..||.||||||||      .|..|||..||| ||:|...|||.  ...|||.|
  Rat    15 GARVVRGPDWKWGKQDGGEGHVGTV------RSFESPEEVVVV-WDNGTAANYRC--SGAYDLRI 70

  Fly    73 VDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGV 137
            :|:|..|::|...:||.|.:..|.||.:|||:|.||.||..||..|.|.:.|.|.|.|||.|..|
  Rat    71 LDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERV 135

  Fly   138 RLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTG 202
            .|..|:.:|:|..||||.|::||||.||:|.:||||.||.|:|.||:.|...|..|.|.|.|..|
  Rat   136 LLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNG 200

  Fly   203 STNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLG-QTEELQPVAPMVKPSFSVGDRVKVCLEVD 266
            :.|:||:|.:|..|||.:....||.:|:||.|||| |.....|      ....:||.|.:.|:::
  Rat   201 AKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGNRNP------GGLQIGDLVNIDLDLE 259

  Fly   267 ALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVK---------- 321
            .:..||.|||||...|.|.|:..|||..|.:..||.|||.: .|||||:||.|.|
  Rat   260 IVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS-GNRWTFNPAVLTKANIVRSGDAA 323

  Fly   322 ------VVSFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDD 380
                  ...|:|||||.:..|..:::.||:|||||.|.|...|||:.:|.::|||.||:::..
  Rat   324 QGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVC-- 386

  Fly   381 GFEWTLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGS-SVADKLVREAAQGHL 444
            |..||.||..|       :..|...:::.:.|..|...::..|.....| .:.::||:.||.|.:
  Rat   387 GTSWTYNPAAV-------SKVAPAGSTISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDV 444

  Fly   445 DFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDKEGDSALHYAAFGNQ 509
            ..|...|......|:....|...:|.||..|:||::..|:.:..:|.|.||:||.|:|:||||::
  Rat   445 AKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDE 509

  Fly   510 PATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQDSYGDTALHDAIGKE 574
            .|.:.||.:..|::|..|....:.|||..:|.....|:.||....:.::|||.|||.|||||.|:
  Rat   510 GAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKK 574

  Fly   575 NTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSR----QLVNVRKDDGFAAL 635
            ..:::.:|..| ..|.|:.||.|||.||||||:||..|.|  :|||:    .:|:.:||||:.||
  Rat   575 RDDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMR--VLLSKLPRPWIVDEKKDDGYTAL 636

  Fly   636 HLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDEDGDN 700
            ||||||.|.:|.|.||.:|.|.|||:|..|||...|||.:.|..::..|||....::.:|:|||.
  Rat   637 HLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDT 701

  Fly   701 AMHLCVIKKSNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSILIYLSRAGCRVELNNAN 765
            .:|                                      :.|.:..|..|.:.....::...:
  Rat   702 PLH--------------------------------------EALRHHTLSQLRQLQDMQDVGKVD 728

  Fly   766 ASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEESSASAGA---ESNGAGPGSVA 827
            |:   |...::...:..|.||                    .|:.||::.|   .:|||
  Rat   729 AA---WEPSKNTLIMGLGTQG--------------------AEKKSAASIACFLAANGA------ 764

  Fly   828 APPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVT 892
                    ...:..|.        |.||......|.:.|..:....:.||.||..|    .|.:.
  Rat   765 --------DLSIRNKK--------GQSPLDLCPDPSLCKALAKCHKEKVSGQVGSR----SPSMI 809

  Fly   893 TSSSSTALEAGAA---------GP----STSPVIVPGP----------------HECIVCNEILP 928
            ::.|.|..|....         ||    :|..:..|..                .||:||::...
  Rat   810 SNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKA 874

  Fly   929 MVRFEPCQHQIACEECGIRMKKCLRCAVAIERR---LTVSGRVVALPTSTSSPSDPTRLPSGDL- 989
            .|.|:||.|..|||.|...||||::|...:|||   :|..|     ..|:..|||.  :.||::
  Rat   875 AVLFQPCGHMCACENCASLMKKCVQCRAVVERRVPFITCCG-----GKSSEEPSDD--ISSGNIP 932

  Fly   990 --------------LRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRK 1040
                          ::.|:.::.:.:|...|.:|::|.:::.||||||.|..|.:.:..|.:|||
  Rat   933 VLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRK 997

  Fly  1041 TILKKINLY 1049
            .|.::|.||
  Rat   998 AIERRILLY 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184	35/64 (55%)
		ZZ_Mind_bomb	85..129	CDD:239079	20/43 (47%)
		MIB_HERC2	156..220	CDD:284184	33/63 (52%)
		ANK	464..582	CDD:238125	45/117 (38%)
		ANK repeat	464..494	CDD:293786	10/29 (34%)
		Ank_2	468..560	CDD:289560	32/91 (35%)
		ANK repeat	496..527	CDD:293786	13/30 (43%)
		ANK repeat	529..560	CDD:293786	7/30 (23%)
		Ank_5	549..604	CDD:290568	25/54 (46%)
		ANK	557..685	CDD:238125	65/131 (50%)
		ANK repeat	596..628	CDD:293786	17/35 (49%)
		Ank_2	601..695	CDD:289560	47/97 (48%)
		ANK repeat	630..662	CDD:293786	20/31 (65%)
		ANK repeat	664..695	CDD:293786	10/30 (33%)
		zf-C3HC4_3	918..961	CDD:290631	19/42 (45%)
		zf-C3HC4_3	1002..1044	CDD:290631	17/41 (41%)
Mib1	NP_001100875.1	MIB_HERC2	15..72	CDD:399589	36/65 (55%)
		ZZ_Mind_bomb	83..127	CDD:239079	20/43 (47%)
		MIB_HERC2	154..218	CDD:399589	33/63 (52%)
		SH3_15	246..311	CDD:408152	30/65 (46%)
		SH3_15	333..397	CDD:408152	30/65 (46%)
		PHA03095	439..>710	CDD:222980	113/311 (36%)
		ANK repeat	464..494	CDD:293786	10/29 (34%)
		ANK repeat	496..560	CDD:293786	21/63 (33%)
		ANK repeat	562..593	CDD:293786	13/31 (42%)
		ANK repeat	631..663	CDD:293786	20/31 (65%)
		ANK repeat	665..696	CDD:293786	10/30 (33%)
		Ank_2	670..770	CDD:403870	27/174 (16%)
		RING1-HC_MIB1	818..854	CDD:319638	5/35 (14%)
		RING2-HC_MIB1	865..901	CDD:319639	17/35 (49%)
		RING3-HC_MIB1	962..1003	CDD:319641	16/40 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119594at33208
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.720