DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mib2 and Sqstm1

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_035148.1	Gene:	Sqstm1 / 18412	MGIID:	107931	Length:	442	Species:	Mus musculus

Alignment Length:	337	Identity:	75/337 - (22%)
Similarity:	114/337 - (33%)	Gaps:	129/337 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 HSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKGAK 146
            |.||:||||: ..:.|..:||:.||:|.||:.|..:.||. ||..:.:  ||..|
Mouse   123 HPNVICDGCN-GPVVGTRYKCSVCPDYDLCSVCEGKGLHR-EHSKLIF--PNPFG---------- 173

  Fly   147 RIQLRGIFVGSKVVR--------GPDWE------WNEQD--GGEGRTGRVMEIRGWDNESCRSVA 195
              .|...|..|:.:|        .|.||      |:.:.  .|:||.....|......|.    .
Mouse   174 --HLSDSFSHSRWLRKLKHGHFGWPGWEMGPPGNWSPRPPRAGDGRPCPTAESASAPPED----P 232

  Fly   196 NVAWVTG-----STNVYRLGHKGNVDLKY------ITAT-------------------CGGHYYK 230
            ||.::..     :..:..||.:.::|:::      :|.|                   |.....|
Mouse   233 NVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPTTPESSSTGTEDKSNTQPSSCSSEVSK 297

  Fly   231 ----DHMPVLGQTEEL---------QPVAPMVKPSFSVGDRVKVCL---EVD------------- 266
                ...|....||::         ||...|...:.|.||.....|   |||
Mouse   298 PDGAGEGPAQSLTEQMKKIALESVGQPEEQMESGNCSGGDDDWTHLSSKEVDPSTGELQSLQMPE 362

  Fly   267 -----ALMKLQQGHGGW-------------NPRMVEHLSKL---------GTVHRI--TDKGDI- 301
                 :|...|:|..|.             :||::|.||::         |.:.|:  |...||
Mouse   363 SEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIG 427

  Fly   302 ----RVQYENCP 309
                .:||...|
Mouse   428 AALDTIQYSKHP 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184
		ZZ_Mind_bomb	85..129	CDD:239079	18/43 (42%)
		MIB_HERC2	156..220	CDD:284184	16/90 (18%)
		ANK	464..582	CDD:238125
		ANK repeat	464..494	CDD:293786
		Ank_2	468..560	CDD:289560
		ANK repeat	496..527	CDD:293786
		ANK repeat	529..560	CDD:293786
		Ank_5	549..604	CDD:290568
		ANK	557..685	CDD:238125
		ANK repeat	596..628	CDD:293786
		Ank_2	601..695	CDD:289560
		ANK repeat	630..662	CDD:293786
		ANK repeat	664..695	CDD:293786
		zf-C3HC4_3	918..961	CDD:290631
		zf-C3HC4_3	1002..1044	CDD:290631
Sqstm1	NP_035148.1	Interaction with LCK. /evidence=ECO:0000250\|UniProtKB:Q13501	2..50
		PB1_p62	5..102	CDD:99723
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000250\|UniProtKB:O08623	43..107
		Interaction with PAWR. /evidence=ECO:0000250\|UniProtKB:Q13501	50..80
		Interaction with GABRR3. /evidence=ECO:0000250\|UniProtKB:O08623	122..224		34/116 (29%)
		ZZ_NBR1_like	126..166	CDD:239080	18/41 (44%)
		LIM protein-binding. /evidence=ECO:0000250\|UniProtKB:Q13501	170..220		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..234		6/33 (18%)
		TRAF6-binding. /evidence=ECO:0000250\|UniProtKB:Q13501	228..233		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..308		5/45 (11%)
		Interaction with NTRK1. /evidence=ECO:0000250\|UniProtKB:O08623	269..442		34/171 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..386		14/64 (22%)
		MAP1LC3B-binding. /evidence=ECO:0000250\|UniProtKB:Q13501	323..344		6/20 (30%)
		LIR	338..343		0/4 (0%)
		Interaction with KEAP1. /evidence=ECO:0000269\|PubMed:20173742, ECO:0000269\|PubMed:20421418	349..354		1/4 (25%)
		UBA_5	381..442	CDD:318725	13/59 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900