DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mib2 and mib-1

DIOPT Version :9

Sequence 1:	NP_001260554.1	Gene:	mib2 / 35170	FlyBaseID:	FBgn0086442	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_499452.2	Gene:	mib-1 / 176558	WormBaseID:	WBGene00012933	Length:	765	Species:	Caenorhabditis elegans

Alignment Length:	878	Identity:	179/878 - (20%)
Similarity:	304/878 - (34%)	Gaps:	226/878 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 FSVGDRVKVCLEVDALMKLQQGHGGWNPRM---------VEHLSKLGTV--------HRITDKGD 300
            |:.|||:.:          .:.|.....|:         ..||:.||.:        ||.|  .:
Worm    18 FTPGDRILI----------SENHPNHAQRLNSYNNVAWTKTHLALLGHIGYIESINEHRHT--AN 70

  Fly   301 IRVQYENCPN--------RWTFHPAALVKVVSFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHA 357
            :||.|....|        .|........:.:....||||.|          .:|..|...|...|
Worm    71 VRVYYAVPQNPELFKLSTEWPLDALEFPQCIDHSKGDLVAI----------TRGDPEKTTIGIVA 125

  Fly   358 ------LGKICK-VVKVYSDGDLRIQQ-----LDDGFEWTLNPK----CVKLERSPLATAAERSN 406
                  ||.|.| :|::.|..:..|.:     ::....||...:    |.......|:..|..:|
Worm   126 TKEPLNLGGIPKHLVQLKSASNPTITREIQVAVNANTGWTDERRDIFLCPVYSGPRLSMIARDNN 190

  Fly   407 SMMDLSHRRADHVMTPLSGLSGSSVADKLVREAAQGHLDFVRQYLDV-----NPSQVDVMSGGKA 466
            .....:::...|..||          |.|::..|....|.:...|.|     :|.||..:..|:.
Worm   191 EPSVHTYKHTIHGYTP----------DTLMQVIANWGEDALSYALLVESIRSDPQQVRTLFDGQL 245

  Fly   467 CIQVASHQGYVDLVSYLISKGANVNAVDKEGDSALHYAA-FGNQPATMRVLLQHGAEVNFLNSSH 530
            .:..|......::|..|::.||:..|.|.|..:.:|.|| .|.......|:|....::|...::.
Worm   246 PLFRAVADDLRNVVVMLVALGADRTARDSENRTIIHVAAERGLDKMLDTVMLLLPKDINSQAANG 310

  Fly   531 CSALHICAHKKTPHCVRELLQHNANVN-IQDSYGDTALHDAI-----GKENTEVVELLCNA-PNL 588
            .:.||:.|......|:..||..:..:. :.:::|||.||:..     ..:...:..:|.|. .|:
Worm   311 LTPLHLAARHAHAACIDRLLGTSTCIPCVPNNFGDTLLHEVCRLPESSNKKAAISRILTNTRANI 375

  Fly   589 DFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQLVNVRKDDGFAALHLAALNGHAQVVETLVTE 653
            ...  ||.....:..|.:.|:|....::|||.....|.....|.:|||.||
Worm   376 HHV--NNSNMTPIQIAIMSGHVSTVEQLLLLRASYRNTTSKTGMSALHFAA-------------- 424

  Fly   654 GQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDEDGDNAMHLCVIKKSNLQSAAEP 718
                                :.|||.|:.:|:.|..:|:.:|:.|...:|..:.|.:   ..||.
Worm   425 --------------------ASGHANVVNKLISLGLEVHRRDKFGRGVLHYALEKWT---GEAEK 466

  Fly   719 QPEEAPEIHKFYLSLVHSSIRPEDRLMYSILIYLSRAGCRVELNNANASIFEWITDRHIRQLIFG 783
            .......|.....:...|:|                    ::| |....:|:.|.:    .|...
Worm   467 DCNRLAAIQALVKAGAPSNI--------------------IDL-NGQTPVFQLIRE----MLSNS 506

  Fly   784 QQGEAESLP-------RNLQALEVSAGSADGEESSASAGAESNGAGPGSVAAPPPPQRQTFELMP 841
            :|..|..:|       .||...|:::......:.:......:|||                :|..
Worm   507 EQYPASLVPVCAQLVRTNLNLDEMASRLRPMWQLATICFLVANGA----------------DLNV 555

  Fly   842 KPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAG 906
            |..               ....|..|..:::.:::...:|..|:....|:..:.|....::....
Worm   556 KDR---------------RGMTVMDLCEESSFRSIIVHIAQTKQRQVMPMMMAMSEDKFDSTEVT 605

  Fly   907 PSTSPVIVPGPHECIVCNEILPMVRFEPCQHQIACEEC--GIRMKKCLRCAVAIERRLTVSGRVV 969
            ..|           ..|...:..|:.:||.|::||.:|  .:.:::|..|...|.......|:.|
Worm   606 MCT-----------FSCLNSVATVKLDPCGHRVACVDCTEKVAIRRCPVCRQFINEAHDQDGKPV 659

  Fly   970 ALPTSTSSPSDPTRLP-SGDL-----------------------LRYLENKVLEFEESHFCGICM 1010
            .:.:....|||..|.. |.::                       |..|..::.:.|....|.|||
Worm   660 QIGSRCHEPSDGDRQQVSAEVRKQIADDAAREAKIEVEREKQNELNQLRKRLEQLELETNCAICM 724

  Fly  1011 ERKRDVAFLCGHGACSHCAETL-RTCHMCRKTI 1042
            :.|..|.|.|||.||..||:.| :.||:|||||
Worm   725 DLKIAVVFNCGHTACVDCADKLKKQCHICRKTI 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_001260554.1	MIB_HERC2	8..73	CDD:284184
		ZZ_Mind_bomb	85..129	CDD:239079
		MIB_HERC2	156..220	CDD:284184
		ANK	464..582	CDD:238125	27/124 (22%)
		ANK repeat	464..494	CDD:293786	7/29 (24%)
		Ank_2	468..560	CDD:289560	21/93 (23%)
		ANK repeat	496..527	CDD:293786	8/31 (26%)
		ANK repeat	529..560	CDD:293786	6/31 (19%)
		Ank_5	549..604	CDD:290568	12/61 (20%)
		ANK	557..685	CDD:238125	27/134 (20%)
		ANK repeat	596..628	CDD:293786	7/31 (23%)
		Ank_2	601..695	CDD:289560	20/93 (22%)
		ANK repeat	630..662	CDD:293786	6/31 (19%)
		ANK repeat	664..695	CDD:293786	7/30 (23%)
		zf-C3HC4_3	918..961	CDD:290631	11/44 (25%)
		zf-C3HC4_3	1002..1044	CDD:290631	22/42 (52%)
mib-1	NP_499452.2	ANK repeat	242..273	CDD:293786	7/30 (23%)
		Ank_2	247..>313	CDD:289560	15/65 (23%)
		ANK repeat	275..307	CDD:293786	8/31 (26%)
		ANK	341..459	CDD:238125	33/153 (22%)
		ANK repeat	343..379	CDD:293786	8/37 (22%)
		Ank_4	344..402	CDD:290365	13/59 (22%)
		Ank_4	382..436	CDD:290365	17/87 (20%)
		ANK repeat	384..413	CDD:293786	7/28 (25%)
		ANK	410..579	CDD:238125	41/261 (16%)
		ANK repeat	415..446	CDD:293786	13/64 (20%)
		Ank_2	420..>494	CDD:289560	22/131 (17%)
		ANK repeat	448..488	CDD:293786	8/62 (13%)
		ANK repeat	490..557	CDD:293786	14/86 (16%)
		zf-C3HC4_3	611..650	CDD:290631	11/38 (29%)
		zf-C3HC4_3	717..760	CDD:290631	22/41 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157880
Domainoid	1	1.000	50	1.000	Domainoid score	I7840
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I3129
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002693
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104088
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880