DRSC/TRiP Functional Genomics Resources

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Protein Alignment mib2 and MIB2

DIOPT Version :10

Sequence 1:NP_609933.1 Gene:mib2 / 35170 FlyBaseID:FBgn0086442 Length:1049 Species:Drosophila melanogaster
Sequence 2:XP_047302550.1 Gene:MIB2 / 142678 HGNCID:30577 Length:1267 Species:Homo sapiens


Alignment Length:1047 Identity:395/1047 - (37%)
Similarity:549/1047 - (52%) Gaps:199/1047 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 VRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKG 144
            |||.|::||.|.|.|:.|:.:||..|.:|.||..||..:.|::.|.|.||.|.:|..|.|..|:|
Human   342 VRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQG 406

  Fly   145 AKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRL 209
            ..||.|||||.|:||||||||||..||||||:.|||::|||||.|:.||||:|.|..|:|||||:
Human   407 LPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRV 471

  Fly   210 GHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVCLEVDALMKLQQG 274
            ||||.||||.:....||.|||||:|.||:..|||.........|..||:||..|:.|.|.::|:|
Human   472 GHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEG 536

  Fly   275 HGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVV---------------- 323
            ||||||||.|.:.:.||||||||:||:|||: |...||||||.||.|..                
Human   537 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQF-NHETRWTFHPGALTKDTRKAGQLRGREGGGWAK 600

  Fly   324 -----SFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFE 383
                 ||.|||:|.:|.|.:.|::||.|||||.:.|..|||::.|||||:.||:||:...  |..
Human   601 MLLHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVA--GQR 663

  Fly   384 WTLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVA-DK------------- 434
            ||.:|.|       |.......::.:|::.|..::       .|..||| ||             
Human   664 WTFSPSC-------LVAYRPEEDANLDVAERAREN-------KSSLSVALDKLRAQKSDPEHPGR 714

  Fly   435 LVREAAQGH----LDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDK 495
            ||.|.|.|:    ||.:|:    .|.|||..:.|:..:|||::.|.|:|:..|:...|.|:..|.
Human   715 LVVEVALGNAARALDLLRR----RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDD 775

  Fly   496 EGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQD 560
            ||::||||||.||||...||||..|...:.:||:..:|||:...:.....||.|.:...:||:.|
Human   776 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 840

  Fly   561 SYGDTALHDAI--GKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQL 623
            ::.||.||.||  |...:.:||:|...||:|.|..|::||.:||||:|||:.:|.|:||..:|||
Human   841 AHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQL 905

  Fly   624 VNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLS 688
            |:.:|:|||.||||||||.|.:|.:.|:.||:.::::||.:.|:|..|||.|.|.|::..||...
Human   906 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 970

  Fly   689 CDVNAKDEDGDNAMHLCVIKKSNLQSAA-----EPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSI 748
            |.|||:||:||.|:|:.:.:...|...|     :|.|                            
Human   971 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGP---------------------------- 1007

  Fly   749 LIYLSRA------GCRV----ELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAG 803
            |..|||.      ||:|    .|..|.|.....:..        ..|.:|..||   .:.|::.|
Human  1008 LQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCP--------AAQLQASGLP---GSAELTVG 1061

  Fly   804 SA-------DGEESSASAGAESNGAGPGSVAAPPP------------PQRQTFELMPKPNDIPAI 849
            :|       :|.:.|.:   ...|..|..:||...            .:||.             
Human  1062 AAVACFLALEGADVSYT---NHRGRSPLDLAAEGRVLKALQGCAQRFRERQA------------- 1110

  Fly   850 GVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIV 914
            |.||:|                              .|:..:.|.::.|.|..|||         
Human  1111 GGGAAP------------------------------GPRQTLGTPNTVTNLHVGAA--------- 1136

  Fly   915 PGPH--ECIVCNEILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSS 977
            |||.  ||:||:|:..:|.|.||||:..||||..|||||:||.|.:.::|...|..||  ::..:
Human  1137 PGPEAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGSEVA--SAAPA 1199

  Fly   978 PSDPTRLPSGDLLRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTI 1042
            |..|.:     |:..|:::..:.||...|.||::....:.|.||||||:.|...|..|.:||:.|
Human  1200 PGPPRQ-----LVEELQSRYRQMEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPI 1259

  Fly  1043 LKKINLY 1049
            ..:|.::
Human  1260 RDRIQIF 1266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib2NP_609933.1 MIB_HERC2 8..74 CDD:461991
ZZ_Mind_bomb 85..129 CDD:239079 17/43 (40%)
MIB_HERC2 156..220 CDD:461991 46/63 (73%)
SH3_15 253..319 CDD:465720 39/65 (60%)
SH3_15 325..391 CDD:465720 32/65 (49%)
ANKYR 398..664 CDD:440430 111/285 (39%)
ANK repeat 464..494 CDD:293786 10/29 (34%)
ANK repeat 496..527 CDD:293786 17/30 (57%)
ANK repeat 529..560 CDD:293786 8/30 (27%)
ANK repeat 596..628 CDD:293786 17/31 (55%)
ANK repeat 630..662 CDD:293786 16/31 (52%)
Ank_5 650..705 CDD:433530 25/54 (46%)
ANK repeat 664..695 CDD:293786 14/30 (47%)
PRK14959 <791..>919 CDD:184923 27/148 (18%)
RING-HC_MIB2_rpt1 918..955 CDD:438386 21/38 (55%)
RING-HC_MIBs-like 1004..1042 CDD:438183 15/37 (41%)
MIB2XP_047302550.1 PHA03247 <6..337 CDD:223021
ZZ_Mind_bomb 347..391 CDD:239079 17/43 (40%)
MIB_HERC2 418..482 CDD:461991 46/63 (73%)
SH3_15 515..580 CDD:465720 39/65 (60%)
SH3_15 607..671 CDD:465720 33/72 (46%)
ANKYR 678..947 CDD:440430 110/279 (39%)
ANK repeat 744..774 CDD:293786 10/29 (34%)
ANK repeat 776..807 CDD:293786 17/30 (57%)
ANK repeat 809..840 CDD:293786 8/30 (27%)
ANK repeat 842..876 CDD:293786 14/33 (42%)
ANK repeat 879..910 CDD:293786 17/30 (57%)
ANK repeat 912..944 CDD:293786 16/31 (52%)
Ank_2 917..993 CDD:463710 34/75 (45%)
ANK repeat 946..977 CDD:293786 14/30 (47%)
RING-HC_MIB2_rpt1 1142..1179 CDD:438386 21/36 (58%)
RING_Ubox 1217..1267 CDD:473075 19/50 (38%)
Blue background indicates that the domain is not in the aligned region.

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