DRSC/TRiP Functional Genomics Resources

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Protein Alignment mib2 and MIB2

DIOPT Version :9

Sequence 1:NP_001260554.1 Gene:mib2 / 35170 FlyBaseID:FBgn0086442 Length:1049 Species:Drosophila melanogaster
Sequence 2:XP_016855838.1 Gene:MIB2 / 142678 HGNCID:30577 Length:1297 Species:Homo sapiens


Alignment Length:1073 Identity:396/1073 - (36%)
Similarity:549/1073 - (51%) Gaps:227/1073 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 VRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKG 144
            |||.|::||.|.|.|:.|:.:||..|.:|.||..||..:.|::.|.|.||.|.:|..|.|..|:|
Human   348 VRHPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQG 412

  Fly   145 AKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRL 209
            ..||.|||||.|:||||||||||..||||||:.|||::|||||.|:.||||:|.|..|:|||||:
Human   413 LPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRV 477

  Fly   210 GHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVCLEVDALMKLQQG 274
            ||||.||||.:....||.|||||:|.||:..|||.........|..||:||..|:.|.|.::|:|
Human   478 GHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKCLLDTDVLREMQEG 542

  Fly   275 HGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVV---------------- 323
            ||||||||.|.:.:.||||||||:||:|||: |...||||||.||.|..                
Human   543 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQF-NHETRWTFHPGALTKDTRKAGQLRGREGGGWAK 606

  Fly   324 -----SFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFE 383
                 ||.|||:|.:|.|.:.|::||.|||||.:.|..|||::.|||||:.||:||:...  |..
Human   607 MLLHHSFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVA--GQR 669

  Fly   384 WTLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVA-DK------------- 434
            ||.:|.|       |.......::.:|::.|..::       .|..||| ||             
Human   670 WTFSPSC-------LVAYRPEEDANLDVAERAREN-------KSSLSVALDKLRAQKSDPEHPGR 720

  Fly   435 LVREAAQGH----LDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDK 495
            ||.|.|.|:    ||.:|:    .|.|||..:.|:..:|||::.|.|:|:..|:...|.|:..|.
Human   721 LVVEVALGNAARALDLLRR----RPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDD 781

  Fly   496 EGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQD 560
            ||::||||||.||||...||||..|...:.:||:..:|||:...:.....||.|.:...:||:.|
Human   782 EGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPD 846

  Fly   561 SYGDTALHDAI--GKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQL 623
            ::.||.||.||  |...:.:||:|...||:|.|..|::||.:||||:|||:.:|.|:||..:|||
Human   847 AHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQL 911

  Fly   624 VNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLS 688
            |:.:|:|||.||||||||.|.:|.:.|:.||:.::::||.:.|:|..|||.|.|.|::..||...
Human   912 VDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAG 976

  Fly   689 CDVNAKDEDGDNAMHLCVIKKSNLQSAA-----EPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSI 748
            |.|||:||:||.|:|:.:.:...|...|     :|.|                            
Human   977 CSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPGP---------------------------- 1013

  Fly   749 LIYLSRA------GCRV----ELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAG 803
            |..|||.      ||:|    .|..|.|.....:..        ..|.:|..||          |
Human  1014 LQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCP--------AAQLQASGLP----------G 1060

  Fly   804 SADGEESSASA------GAE---SNGAGPGSVAAPPPPQRQTFELMPKPNDIPAI---------- 849
            ||:....:|.|      ||:   :|..|           |...:|..:...:.|:          
Human  1061 SAELTVGAAVACFLALEGADVSYTNHRG-----------RSPLDLAAEGRVLKALQGCAQRFRER 1114

  Fly   850 --GVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPV 912
              |.||:|                              .|:..:.|.::.|.|..|||       
Human  1115 QAGGGAAP------------------------------GPRQTLGTPNTVTNLHVGAA------- 1142

  Fly   913 IVPGPH--ECIVCNEILPMVRFEPCQHQIACE------------------------ECGIRMKKC 951
              |||.  ||:||:|:..:|.|.||||:..||                        ||..|||||
Human  1143 --PGPEAAECLVCSELALLVLFSPCQHRTVCEGEWGAPGWGGPASRAAANRALLFAECARRMKKC 1205

  Fly   952 LRCAVAIERRLTVSGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLEFEESHFCGICMERKRDV 1016
            :||.|.:.::|...|..||  ::..:|..|.:     |:..|:::..:.||...|.||::....:
Human  1206 IRCQVVVSKKLRPDGSEVA--SAAPAPGPPRQ-----LVEELQSRYRQMEERITCPICIDSHIRL 1263

  Fly  1017 AFLCGHGACSHCAETLRTCHMCRKTILKKINLY 1049
            .|.||||||:.|...|..|.:||:.|..:|.::
Human  1264 VFQCGHGACAPCGSALSACPICRQPIRDRIQIF 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mib2NP_001260554.1 MIB_HERC2 8..73 CDD:284184
ZZ_Mind_bomb 85..129 CDD:239079 17/43 (40%)
MIB_HERC2 156..220 CDD:284184 46/63 (73%)
ANK 464..582 CDD:238125 48/119 (40%)
ANK repeat 464..494 CDD:293786 10/29 (34%)
Ank_2 468..560 CDD:289560 37/91 (41%)
ANK repeat 496..527 CDD:293786 17/30 (57%)
ANK repeat 529..560 CDD:293786 8/30 (27%)
Ank_5 549..604 CDD:290568 23/56 (41%)
ANK 557..685 CDD:238125 61/129 (47%)
ANK repeat 596..628 CDD:293786 17/31 (55%)
Ank_2 601..695 CDD:289560 48/93 (52%)
ANK repeat 630..662 CDD:293786 16/31 (52%)
ANK repeat 664..695 CDD:293786 14/30 (47%)
zf-C3HC4_3 918..961 CDD:290631 23/68 (34%)
zf-C3HC4_3 1002..1044 CDD:290631 17/41 (41%)
MIB2XP_016855838.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143831
Domainoid 1 1.000 108 1.000 Domainoid score I6446
eggNOG 1 0.900 - - E1_KOG4582
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H16062
Inparanoid 1 1.050 701 1.000 Inparanoid score I676
Isobase 1 0.950 - 0 Normalized mean entropy S6907
OMA 1 1.010 - - QHG47157
OrthoDB 1 1.010 - - D119594at33208
OrthoFinder 1 1.000 - - FOG0002693
OrthoInspector 1 1.000 - - oto90976
orthoMCL 1 0.900 - - OOG6_104088
Panther 1 1.100 - - LDO PTHR24202
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R13065
SonicParanoid 1 1.000 - - X100
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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