Protein Alignment mib2 and mib1

DIOPT Version :10

• Sequence 1: NP_609933.1
• Gene: mib2 / 35170
• FlyBaseID: FBgn0086442
• Length: 1049
• Species: Drosophila melanogaster
• Sequence 2: XP_061509044.1
• Gene: mib1 / 1280737
• VectorBaseID: AGAMI1_000417
• Length: 1213
• Species: Anopheles gambiae
• Alignment Length: 1237
• Identity: 385/1237 - (31%)
• Similarity: 580/1237 - (46%)
• Gaps: 256/1237 - (20%)

  Fly     8 GIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLII 72
            |.||:|||:|.|..||.||||||||      .:..|.|..||| ||:|...|||..  ..|||.|
Mosquito    38 GSRVIRGPDWKWGKQDGGEGHVGTV------RNFESQEEVVVV-WDNGTAANYRCA--GAYDLRI 93

  Fly    73 VDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGV 137
            :|:|..|::|...:||.|.:..|.||.:|||:|.||.||:.||..|.|.:.|.|.|.|||.....
Mosquito    94 LDSAPTGIKHEGTMCDTCRQQPIFGIRWKCAECNNYDLCSICYQSDKHHLRHRFHRITTPGGEKT 158

  Fly   138 RLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTG 202
            .|..|:.:|:|.:||||.|::||||.||:|.:||||.||.|:|.|::.|.:.|.||.|.|.|..|
Mosquito   159 LLEPRRKSKKIAVRGIFPGARVVRGVDWQWEDQDGGNGRRGKVNEVQDWSSASPRSAAYVVWDNG 223

  Fly   203 STNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKP-SFSVGDRVKVCLEVD 266
            :.|:||:|.:|..|||.:....|...|:||:|:||:      ..|...| :|.:||:|.|.|:::
Mosquito   224 AKNLYRVGFEGMADLKVVNDAKGMTVYRDHLPLLGE------YGPGRAPNNFQIGDQVTVDLDIE 282

  Fly   267 ALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVS------- 324
            .:..||.|||||...|.|.||..|||..|.:..||.|.|.: .:||||:|..|..|.|
Mosquito   283 IVQSLQHGHGGWTDGMFECLSTTGTVVGIDEDHDIVVAYPS-SHRWTFNPTVLTIVSSPMMLLAD 346

  Fly   325 -----FRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEW 384
                 |.|||.|.|.:|..:::.||:|||||.|.|...|||:.:|.:||.|.||:::..:.  .|
Mosquito   347 NQPQQFAVGDFVKICSDLERIKILQRGHGEWAEAMVPTLGKVGRVQQVYHDNDLKVEVCNT--SW 409

  Fly   385 TLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVADKLVREAAQGHLDFVRQ 449
            |.||..|    :.:|::::.:.::.....|.:..:.......:.....::||:.||.|....|.:
Mosquito   410 TYNPLAV----TKVASSSDGATAVTTNGERLSAILKKLFEPHASGDTTEELVKAAANGDKAKVEE 470

  Fly   450 YL-------DVNPS------------------QVDV--MSGGKACIQVASHQGYVDLVSYLISKG 487
            :|       :|.||                  :|||  :..|...:|.||..|:::::..|:...
Mosquito   471 FLIGSAGGQNVTPSSSSAAGAAASLGETQSVVKVDVNGVFAGHTALQAASQNGHLEVIEVLLRHN 535

  Fly   488 ANVNAVDKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQH 552
            |:|...||:||.|:|:||||::|..|.:|.:.||::|..|....:||||..:|...:.|:.||:.
Mosquito   536 ADVEIEDKDGDRAVHHAAFGDEPGVMGMLAKAGADLNARNKRRQTALHIAVNKGHFNVVKTLLEL 600

  Fly   553 NANVNIQDSYGDTALHDAIGKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRIL 617
            |.:.::|||.|||||||||.||:..::.||.: ...|.|:.||.|||.|||||||||..|.:.:|
Mosquito   601 NCHPSLQDSEGDTALHDAISKEHDNMLALLLD-NGADITLTNNNGFNALHHAALKGNPSAMKVLL 664

  Fly   618 LLSRQL--VNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGV 680
            ..:.:|  |..:||||:.||||||||.|.::.|.||..|:|.:|.:|...||...|||.:.|..:
Mosquito   665 TKTNRLWIVEEKKDDGYTALHLAALNNHVEIAELLVRMGKANMDCQNVNLQTALHLAVERQHVQI 729

  Fly   681 IERLVRLSCDVNAKDEDGDNAMHLCVIKKSNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLM 745
            ::.|||...::|..|:|||..:|      ..|:.....|..:..::..|...|:......:.:..
Mosquito   730 VKLLVREGANLNIPDKDGDTPLH------EALRHHTLSQLRQLQDVEGFGKILMGLRNNTDKKAS 788

  Fly   746 YSILIYLSRAGCRVELNNANASI-FEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEE 809
            .||..:|:..|..:.:.|..... .:...|.::.:.:.....|.::  .::.::.:...|..|
Mosquito   789 ASIACFLAANGADLTIKNRKLQTPLDLCPDPNLCKTLIKCYNERKT--EDMDSMTLGMASHTG-- 849

  Fly   810 SSASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNS----- 869
                     .|.||     ..|.:|..:    :|.|.|.      .||.:.:||...|.|
Mosquito   850 ---------GGGGP-----TMPLRRGGY----RPPDEPI------ASTSAGNPGTSGLGSGGLNH 890

  Fly   870 ---DA------TPQNVSPQVAPRKKAPKPPVTTSSSSTALEAG-------------AAGPSTSP- 911
               ||      :..::.|..|......    .:.:.:||..:|             .||.|:.|
Mosquito   891 AQIDANLLMGLSKMSIQPNAAGEANTN----VSVNHNTASSSGGGGVSVACSVATTTAGDSSGPL 951

  Fly   912 -------------VIVP----------GPH------------------ECIVCNEILPMVRFEPC 935
                         |..|          ||.                  ||:||::....|.|:||
Mosquito   952 DECLLCSDQKRDTVFKPCGHVVCCENCGPRIKKCLICRESVLSREKIDECLVCSDRKASVFFKPC 1016

  Fly   936 QHQIACEECGIRMKKCLRCAVAIERRLTVS------GRVVALP---------------------- 972
            .|.:|||.|...||||::|...:|:.:.:|      |.|:.:.
Mosquito  1017 GHMVACEHCAPIMKKCVQCRTQLEQMVPLSVCSGGQGSVINIQHPVEDGKKDLLHNHNASQQQQQ 1081

  Fly   973 ---------------TSTSSPS----------------------------------------DPT 982
                           .:|.||:                                        .|.
Mosquito  1082 QLLQGTNKAGLGVAMNNTMSPNASALAAGSGSGGVALGNNGQAAGGASSSTGSSNTNASLIVSPN 1146

  Fly   983 RLPSGDLLRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKIN 1047
            .|...|..:.|:.::.:.:|...|.:|.:|.:::.||||||.|..|.:.:..|.:||||:.|:|.
Mosquito  1147 NLNLVDDFQKLQQQLQDIKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIDGCPICRKTVEKRIL 1211

  Fly  1048 LY 1049
            |:
Mosquito  1212 LF 1213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mib2	NP_609933.1	MIB_HERC2	8..74	CDD:461991	33/65 (51%)
		ZZ_Mind_bomb	85..129	CDD:239079	20/43 (47%)
		MIB_HERC2	156..220	CDD:461991	33/63 (52%)
		SH3_15	253..319	CDD:465720	30/65 (46%)
		SH3_15	325..391	CDD:465720	29/65 (45%)
		ANKYR	398..664	CDD:440430	105/294 (36%)
		ANK repeat	464..494	CDD:293786	8/29 (28%)
		ANK repeat	496..527	CDD:293786	14/30 (47%)
		ANK repeat	529..560	CDD:293786	9/30 (30%)
		ANK repeat	596..628	CDD:293786	16/33 (48%)
		ANK repeat	630..662	CDD:293786	17/31 (55%)
		Ank_5	650..705	CDD:433530	21/54 (39%)
		ANK repeat	664..695	CDD:293786	10/30 (33%)
		PRK14959	<791..>919	CDD:184923	31/196 (16%)
		RING-HC_MIB2_rpt1	918..955	CDD:438386	17/54 (31%)
		RING-HC_MIBs-like	1004..1042	CDD:438183	15/37 (41%)
mib1	XP_061509044.1	None