Protein Alignment hook and hook1

DIOPT Version :10

• Sequence 1: NP_476573.1
• Gene: hook / 35169
• FlyBaseID: FBgn0001202
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001038663.1
• Gene: hook1 / 570393
• ZFINID: ZDB-GENE-041001-159
• Length: 715
• Species: Danio rerio
• Alignment Length: 738
• Identity: 251/738 - (34%)
• Similarity: 400/738 - (54%)
• Gaps: 82/738 - (11%)

  Fly     1 MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSN 65
            |...|..:..||:.|.:|....||....|.|..|.|::|||:|..|..|:::||::||.. ||.|
Zfish     1 MDLKKTVLCESLIIWLQTFKTAAPCKTVEDLTSGAAMSQALHQIDPSWFSESWLARIKED-VGDN 64

  Fly    66 WRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQ 130
            .||:|:||||:.|.:.|||::||...:|||..|||.|:.|:.|..||.|||||:|||||.|..||
Zfish    65 VRLKMNNLKKILQMIVDYYNEVLAQQMSDFPLPDLMRVVEQSDQVELGRLLQLILGCAVKCDRKQ 129

  Fly   131 SYITEIMCLEEELQANIMRALQELEATRQAS----TPEGGVASSLSRGSRTGLLDSKAVQEDRDA 191
            .||..||.|||.:|..:|.|:|||.:....|    .|.|.....|.:    .|.|...|..:::.
Zfish   130 EYIQIIMTLEESVQHVVMTAIQELMSRESVSQLGAEPAGDTEQQLKK----ALEDLTEVMAEKEE 190

  Fly   192 LAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRR 256
            |||:|.|.:.::.:|.:|:.:|..|...|....::||..     ||     |......::::|:.
Zfish   191 LAQRCQELDMQVTVLQEERNSLLAENDLLTDRSSQLETF-----DD-----PSTPSGRKHSQLQF 245

  Fly   257 QLDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLK 321
            ||:.|:||..:.|.|::|.:|..::.:..|:.:|.|.:||...:.|..:||||:|:||..:|:..
Zfish   246 QLEQLQEENFRLEAAKDDYRIHCEELEKQLVELQHRNDELTSLAEESRSLKDELDILRSCSDRAV 310

  Fly   322 ICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLH 386
            ..||.::||:|||||.:||::|:|.|||::..|:......||:.::....:.|:|.:|:::|:||
Zfish   311 KLEASVETYRKKLEDLSDLRRQMKALEEKNMTYMHNTVSLEEELRKANAARAQLETYKRQVQELH 375

  Fly   387 AKLDAESSKNVKLEFDNKNLESKNLALQRAKDSLLKERDNLREAVDELKCGQLSSNTAL------ 445
            .||..||.:...|.|:.|.|:.|..||.:.::.:..|||.|||..:||:|.|...:..|
Zfish   376 KKLSDESRRADNLVFEMKKLQEKYDALVKERERISIERDTLRETNEELRCTQAQQDQLLLAGKYQ 440

  Fly   446 TGT----TVSRELQPSATVEKLQRLEAENKALREGQGGQ-----TALAQLLDDANKRCENLREQL 501
            ||:    .::.|:.|....||..||:.|||.||..|...     |.|.|.|::|.:.    |.||
Zfish   441 TGSPSHDNLAAEMLPIEYREKFIRLQHENKMLRLQQEESEKQRITELQQQLEEARRG----RSQL 501

  Fly   502 KTAN----ERILSL------------SHASQSDDPILKESEFGKQIKQLMELNE------QKTLQ 544
            .|.|    |||..|            :..::.||..||.    |....:::|||      :|...
Zfish   502 DTDNRLNRERISELQQQVEDLQKALQTQGAKPDDSHLKR----KLDAHMVQLNEAQDEIMKKKEL 562

  Fly   545 LEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRI--ASA----LD 603
            ||:....:|....|:.:|...|..:::::...:.:|:..:|||::||:::||::  |||    |.
Zfish   563 LEDLQPDATQTSVKMDELMAALKKKDEDMRAMEDRYKMYLEKARDVIRALDPKLNPASAEIQSLK 627

  Fly   604 ASVLEKSADLV---EEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLA----ILMGSGQTFL 661
            ..:.:|...::   .|..:.|:...||:|:.:|:|...:|.|:.||:|:|:    .|:..||:||
Zfish   628 VQLSDKDKKIIALERECEQAKLREYEEKLIVTAWYNKSLNFQKMAIESRLSGRANSLVPPGQSFL 692

  Fly   662 ARQRQ-SAPRKSLS----AMKSK 679
            |:||| :..|:::|    |..||
Zfish   693 AQQRQVTNARRTMSINVPASSSK 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK_N	7..158	CDD:465958	73/150 (49%)
		HOOK	181..674	CDD:461694	167/543 (31%)
hook1	NP_001038663.1	HkD_Hook1	8..157	CDD:411796	73/149 (49%)
		HOOK	180..706	CDD:461694	167/543 (31%)