Protein Alignment hook and ccdc88c

DIOPT Version :10

• Sequence 1: NP_476573.1
• Gene: hook / 35169
• FlyBaseID: FBgn0001202
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001410799.1
• Gene: ccdc88c / 553231
• ZFINID: ZDB-GENE-100419-3
• Length: 1997
• Species: Danio rerio
• Alignment Length: 725
• Identity: 172/725 - (23%)
• Similarity: 312/725 - (43%)
• Gaps: 141/725 - (19%)

  Fly     6 NEMYYSLLEWFKTLN-LNAPHADAES----LADGVALAQALNQFAPESFTDAWLSKIKASAVGSN 65
            |.|...|:.|.||.. |.....|..|    |.|||.|.:.:....|..     :::.....|.::
Zfish    11 NFMDSPLVVWVKTFGPLGFSSEDKLSMFMDLVDGVFLHKIMTHIDPSP-----MNQRVNKQVNND 70

  Fly    66 WRLRMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEK----CDLGELERLLQLVLGCAVNC 126
            ..||:.||..|.:.:.:||.:.|. .|...:.|::..||:.    ..:.|::|:|.|:|||||.|
Zfish    71 VNLRIQNLNTVIRHIKNYYQEHLQ-QLIVMNLPNVLAIAKDPLSGKSMEEMKRMLLLILGCAVQC 134

  Fly   127 AEKQSYITEIMCLEEELQANIMRALQELEATRQ----------ASTPEGGVASSLSRGSRTGLLD 181
            ..|:..|.:|..|:.|.||.|:..:||:...::          |..|    |..|...|||....
Zfish   135 DRKEEIIEKIKLLDIETQAAIVTHIQEVTHNQENVLDLQWMEVAEIP----AEQLDPLSRTMAFH 195

  Fly   182 SKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIG---DDGVSLGP 243
            .:.:.::||..|:...|              |.||     :::.:.:|.|.::|   .:..||.|
Zfish   196 LRKLIDERDESAELVIE--------------LTQE-----RDYLQSQQPSGLLGFPSPERTSLSP 241

  Fly   244 V--------QTGSVRYNELRRQLDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSS 300
            :        |..:|...:.:.:|...::||.:......|.|.:.::.|:|:..::....:|:..:
Zfish   242 ITLLSKEDRQHLAVELADTKAKLRRSRQELEEKTEQLIDAKNEIERLDSDIQKLKQENTQLLAEA 306

  Fly   301 AEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDA 365
            ..|...:||||.|||...|:...|.:|..:|:||.|.:..|.:::.|.|.:...::..:..||
Zfish   307 RSVRAYRDEVDSLRERAGKVDRLETELSRFKEKLNDVHFYKTRIEELREDNLTLLETKSMLEE-- 369

  Fly   366 KRYANTKGQV----ELFKKEIQDLHAKL-DAESSKNVKLEFDNKNLE---SKNLALQRAKDSLLK 422
             :....:|:.    ||.|:.:| |.:|| |.|    :..:.|.|.||   .:|:.|:      :.
Zfish   370 -QLTGARGRCDKLHELEKENLQ-LRSKLHDIE----IDRDSDKKRLEELLEENMLLE------IS 422

  Fly   423 ERDNLREAVD---ELKCGQLSSNTALTGTTVS--RELQPSATVEKLQRLEAENKALR-------- 474
            ::.::.|:..   ||:  ||:.|..:.....|  .||..||: .:|.:||.||:.|:
Zfish   423 QKQSMNESAHLGWELE--QLAKNNEVNEARKSFVFELNESAS-SRLLKLEKENQCLQSTIQELRE 484

  Fly   475 ------EGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESE------- 526
                  |||.....|.:.....:|:.|.|:.||....:....:.:..:.   ::||.:
Zfish   485 ASINMEEGQLHSLELEKENQSLSKKLERLQSQLDQEKQTTQDMENLGEE---LIKEKQRMEKTLE 546

  Fly   527 --FGKQIKQLMELNEQKTLQLEEAVTQSTS---------LQCKVTQLETNLSAREQEILVYDAKY 580
              ..::.:|:.||.::|     |.:||:.|         .:.:|.::||......|.|.....|.
Zfish   547 TIQAEKDRQISELEQEK-----EHLTQAVSSLRKRAQANSEARVREVETENRILHQTISETGGKL 606

  Fly   581 RKCVEKAKEVIKSIDPRIASALDASVLEKSADLVE-EEPKPKMSVMEEQLMTSAFYRLGVNAQR- 643
            .:...:.::|.|.::         |:.|:.....| |...|::..:.|||...| ..|.:.::|
Zfish   607 ARLEAEKRQVTKELE---------SLRERGERCEELEREVPRLERVREQLQREA-AALKIGSERA 661

  Fly   644 DAIDSKLAIL 653
            :|::.:.|.|
Zfish   662 EALERENATL 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK_N	7..158	CDD:465958	47/159 (30%)
		HOOK	181..674	CDD:461694	117/531 (22%)
ccdc88c	NP_001410799.1	HkD_Daple	12..164	CDD:411799	47/157 (30%)
		PRK02224	<200..740	CDD:179385	117/526 (22%)
		SMC_prok_B	478..1387	CDD:274008	41/212 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1013..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1415..1798
		PHA03307	1416..>1744	CDD:223039
		PHA03307	1618..>1991	CDD:223039
		GBA. /evidence=ECO:0000250|UniProtKB:Q9P219	1674..1702
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1811..1997
		PDZ-binding. /evidence=ECO:0000255	1994..1997