Protein Alignment hook and HOOK1

DIOPT Version :10

• Sequence 1: NP_476573.1
• Gene: hook / 35169
• FlyBaseID: FBgn0001202
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_056972.1
• Gene: HOOK1 / 51361
• HGNCID: 19884
• Length: 728
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 234/732 - (31%)
• Similarity: 384/732 - (52%)
• Gaps: 83/732 - (11%)

  Fly     4 PKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRL 68
            ||..:..||:.|.:|.|..:|..|.:.|..|||:||.|:|.....|.::|||:||.. ||.|||:
Human    10 PKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKED-VGDNWRI 73

  Fly    69 RMSNLKKVTQSVYDYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYI 133
            :.||:|||.|.:..||.:.|...:|:...|||.:|.|..|..||.|||||:||||:||.:||.:|
Human    74 KASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEKKQEHI 138

  Fly   134 TEIMCLEEELQANIMRALQELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFE 198
            ..||.|||.:|..:|.|:|||.:....|:|.......|.:..:..|.:.:....:::.|.|:|.|
Human   139 QNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAEKEELRQRCEE 203

  Fly   199 TEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKE 263
            .:.::..|.|||.:|..|...:.::..:|         ||....|....:.:|...:.||:.|:|
Human   204 LDMQVTTLQDEKNSLVSENEMMNEKLDQL---------DGSFDDPNTVVAKKYFHAQLQLEQLQE 259

  Fly   264 ELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLD 328
            |..:.|.|::|.::..::.:..|:..|.|.:||...:.|...||||:||||.::||....|:.::
Human   260 ENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVE 324

  Fly   329 TYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAES 393
            .|::||:|.|||:||||.|:|.:..|:......||:.|:....:.|:|.:|:::||||.||.:||
Human   325 IYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSES 389

  Fly   394 SKNVKLEFDNKNLESKNLALQRAKDSLLKERDNLREAVDELKCGQLS----SNTALTGT----TV 450
            .:...|.|:.|.||.|:.||.:.|:.|:::||.|:|..:||:|.|:.    :.|..:.|    .:
Human   390 KRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATKSYENL 454

  Fly   451 SRELQPSATVEKLQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQL-------------- 501
            :.|:.|....|...||:.|||.||..|.|         ..|:|.|.|:|||
Human   455 AAEIMPVEYREVFIRLQHENKMLRLQQEG---------SENERIEELQEQLEQKHRKMNELETEQ 510

  Fly   502 KTANERILSLS------HASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQSTSL----- 555
            :.:.|||..|.      ..|..:.....|.|...::||.:|.:.:|..::.|.:.:...|
Human   511 RLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQ 575

  Fly   556 ------QCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVL------- 607
                  ..|:.:||..|..:::::...:.:|:..:|||:.|||::||::..| .|.::
Human   576 PDINQNVQKINELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPA-SAEIMLLRKQLA 639

  Fly   608 --EKSADLVEEEPK-PKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSG-----------Q 658
              |:..:::|.|.| .|....||:|:.||:|...:..|:..::|:|  :.|.|           :
Human   640 EKERRIEILESECKVAKFRDYEEKLIVSAWYNKSLAFQKLGMESRL--VSGGGACSDTGACTPAR 702

  Fly   659 TFLARQRQ-SAPRKSLS 674
            :|||:||. :..|::||
Human   703 SFLAQQRHITNTRRNLS 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK_N	7..158	CDD:465958	69/150 (46%)
		HOOK	181..674	CDD:461694	157/553 (28%)
HOOK1	NP_056972.1	Sufficient for interaction with microtubules	1..555		192/563 (34%)
		HkD_Hook1	15..163	CDD:411796	69/148 (47%)
		Sufficient for homodimerization, interaction wit HOOK2, HOOK3 and AP4M1. /evidence=ECO:0000269|PubMed:32073997	169..444		88/283 (31%)
		HOOK	186..719	CDD:461694	157/553 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..512		9/39 (23%)
		Sufficient for interaction with AKTIP and VPS18. /evidence=ECO:0000269|PubMed:18799622	657..728		19/65 (29%)