Protein Alignment hook and HOOK2

DIOPT Version :10

• Sequence 1: NP_476573.1
• Gene: hook / 35169
• FlyBaseID: FBgn0001202
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001386970.1
• Gene: HOOK2 / 29911
• HGNCID: 19885
• Length: 753
• Species: Homo sapiens
• Alignment Length: 750
• Identity: 226/750 - (30%)
• Similarity: 388/750 - (51%)
• Gaps: 106/750 - (14%)

  Fly     1 MSAPKNEMYYSLLEWFKTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSN 65
            ||..|.|:..|||.|.:|.::.:|.|..:.|:.|:|:|..|||..|..|.:|||..|.... |.|
Human     1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDP-GPN 64

  Fly    66 WRLR------------------------------------MSNLKKVTQSVYDYYSDVLNYSLSD 94
            |:|:                                    :||||.|.:|:.:|..|||.:.:|:
Human    65 WKLKVTSGLLIRGQTGEEMTRDGPARHMSWVMGRKRDRCLVSNLKMVLRSLVEYSQDVLAHPVSE 129

  Fly    95 FSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRALQEL--EAT 157
            ...||:..|.|..|..||.:|||||||||::|.:||.:|..||.|||.:|..:|.|:|||  :.|
Human   130 EHLPDVSLIGEFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDT 194

  Fly   158 RQASTPEG-GVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDEKTNLQQELHKLQ 221
            ..:.:||. |...|.||  |...|..:|  |:.|.|.|:|.:.|::::||.:||.:|.||...|:
Human   195 PDSLSPETYGNFDSQSR--RYYFLSEEA--EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLR 255

  Fly   222 QEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGAREDLKIKAQQQDTDL 286
            :...|.|...|          |..|.. :...|:.||:.|:||..:.|..|||.:::..:.:.::
Human   256 ERMGRPEGEGT----------PGLTAK-KLLLLQSQLEQLQEENFRLESGREDERLRCAELEREV 309

  Fly   287 LHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYNDLKKQVKILEERS 351
            ..:|.|.:.|...:.|...||||:|.||:|:::....||.|.:.:::|.:..:|::||:.||||:
Human   310 AELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN 374

  Fly   352 ADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRA 416
            |.:.::..|.|::.:|..:.:.|:|..::::|:|..:...|:.|..|..|:.:|||.|..::.:.
Human   375 AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKE 439

  Fly   417 KDSLLKERDNLREAVDELKCGQL------SSNTALTGTT-----VSRELQPSATVEKLQRLEAEN 470
            |:.||.|||:||||.:||:|.||      .::.:|..|:     ::.|:.|:...|.|.||:.||
Human   440 KERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLEN 504

  Fly   471 KALREGQGG----QTALAQLLDDANKRCENL-------REQLKTANERILSLSHASQ-----SDD 519
            |.|...:..    |..|.:.|:|||:....|       ::||.....::..|..|.|     ::|
Human   505 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED 569

  Fly   520 PILKESEFGKQIKQL----MELNEQKTL--QLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDA 578
            .||.:.:..:.:::|    :||..::..  :||.....||:.  ::.:|:.||..::.::...:.
Human   570 SILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTAR--RIEELQHNLQKKDADLRAMEE 632

  Fly   579 KYRKCVEKAKEVIKSIDPRIASA---------LDASVLEKSADL----VEEEPKPKMSVMEEQLM 630
            :||:.|:||:.|:::::|:...|         |...:.|:...:    ::.|........||:|:
Human   633 RYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLL 697

  Fly   631 TSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQR 665
            .||:|.:|:..|:.|.:.:..   ...|:|||:||
Human   698 ISAWYNMGMALQQRAGEERAP---AHAQSFLAQQR 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK_N	7..158	CDD:465958	67/188 (36%)
		HOOK	181..674	CDD:461694	146/530 (28%)
HOOK2	NP_001386970.1	HkD_SF	7..192	CDD:425405	67/185 (36%)
		HOOK	215..738	CDD:461694	147/532 (28%)