DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hook and Ccdc88b

DIOPT Version :9

Sequence 1:	NP_476573.1	Gene:	hook / 35169	FlyBaseID:	FBgn0001202	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_215206.6	Gene:	Ccdc88b / 293698	RGDID:	1311475	Length:	1476	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	178/795 - (22%)
Similarity:	288/795 - (36%)	Gaps:	237/795 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LADGVALAQALNQFAPESFTDAWLSKIK---ASAVGSNWRLRMSNLKKVTQSVYDYYSDVLNYSL 92
            |..|..|.:.|...||.|  ...|..:|   ..|....|     ||..:...:.|:|.:.|...:
  Rat    58 LISGDLLLRVLGIIAPSS--RGRLQMVKGHDGPAACRIW-----NLYHLWGRLRDFYQEELQLLI 115

  Fly    93 SDFSKPDLQRIA------EKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQANIMRAL 151
            .. ..||||.:.      |..|  |||.:|:|:||.:|.|..::.:|..|..|..::|:.:..|:
  Rat   116 LS-PPPDLQTLGFDPFSEEAVD--ELEGILRLLLGASVQCEHRELFIRHIQGLSLDVQSELAAAI 177

  Fly   152 QELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQE------------------DRD----ALAQ 194
            ||:      :.|..||..:|     ||...::.|.|                  :||    .||:
  Rat   178 QEV------TQPGAGVVLAL-----TGPESAELVAEELEMQLRNLMGTMSRLVRERDLGAQRLAE 231

  Fly   195 KCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLD 259
            ...|.|...|||.:...|...|                         ||....:::....:.||.
  Rat   232 VLLEREPAHLLLPEASANASAE-------------------------GPSHHLALQLTNAKAQLR 271

  Fly   260 LLKEE-------LLQSEGAREDL--KIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRE 315
            .|::|       ||.|:...:.|  :|:..:|:|..|..|.:..||.:..||  .|::....|..
  Rat   272 RLRQEVEEKAELLLDSQAEVQGLESEIRRLRQETQALSGQAKRAELYREEAE--ALRERAGRLPR 334

  Fly   316 SNDKLKICEAQL---DTYKKKLEDYND-----------LKKQVKILEERSADYVQQNAQFEEDAK 366
            ..::|:.|..:|   :.:|.:||:...           |::|::|..||||
  Rat   335 LQEELRRCRERLHAAEVFKGQLEEERVLSGALEASKVLLEEQLEIARERSA-------------- 385

  Fly   367 RYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRA---------KDSLLK 422
            |...|:.:..|.:..:.:.||.||:...:..:|..:|..||   |.|||:         :.||..
  Rat   386 RLHETQRENLLLRTRLGEAHADLDSLRHQLEQLVEENVELE---LELQRSLEPPPGSPGETSLPG 447

  Fly   423 ERDNLREAVDELKCGQL----SSNTALTGTTVSRELQPSATVEKLQR--LEAENK---------- 471
            ...:|::.|.|.:.|:|    ..|..|.|     :||........||  ||.::|
  Rat   448 AAPSLQDEVREAEAGRLRTVEQENRTLRG-----QLQMLREQLDSQRPLLEEQSKDSMLPVTNGA 507

  Fly   472 -----AL------------REGQG-----------GQTALAQLLD--DANKRCENLREQLK---- 502
                 ||            .||.|           |.|.|::.|.  |::...::..:.:.
  Rat   508 PAAPLALDHSPKSLACQIGGEGPGSLDLPSPASYSGITRLSECLQAPDSHPELDSPFQMVSQDPQ 572

  Fly   503 ------------TANERILSLSHASQSDDPILKESEFGKQIK-QLMELNEQKTLQLEEA------ 548
                        .|::.:....|......||:.:...|.:|: .:.||.|..:.:..|.
  Rat   573 TSDQTQESDPTGEAHQSLEKSGHRVSVQSPIVWDPPQGAEIRIDVQELGETGSREASEGESVPEA 637

  Fly   549 -VTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIK------SIDPRIASALDASV 606
             |.:..:.:|:....|.        ||:...|.:|.:|...|:.|      ..:.|....::..|
  Rat   638 QVLKQENPECRPRSAEF--------ILLEPLKDQKTLEPELELSKQQTETGGHEQRPKGLVNKLV 694

  Fly   607 LEKSADLVE--------EEPKP----KMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQT 659
            |:|.....|        |||.|    ..::.|||.:.....:|     |..:.|..|.|....|.
  Rat   695 LQKPQQTSEGPPDAWSREEPIPGETLATAIPEEQALRDEVAQL-----RREVVSLEAKLQAQAQR 754

  Fly   660 FLARQRQSAPRKSLS 674
            ..||   ||...|||
  Rat   755 LEAR---SAEAVSLS 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK	8..675	CDD:283312	178/795 (22%)
Ccdc88b	XP_215206.6	HkD_Gipie	10..182	CDD:411801	38/139 (27%)
		SMC_prok_B	<262..955	CDD:274008	119/545 (22%)
		SMC_prok_B	<726..>1295	CDD:274008	16/49 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840