Protein Alignment hook and CCDC88B

DIOPT Version :9

• Sequence 1: NP_476573.1
• Gene: hook / 35169
• FlyBaseID: FBgn0001202
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_011543259.1
• Gene: CCDC88B / 283234
• HGNCID: 26757
• Length: 1639
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 150/665 - (22%)
• Similarity: 240/665 - (36%)
• Gaps: 218/665 - (32%)

  Fly    31 LADGVALAQALNQFAPES-----------FTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVYDYY 84
            |:||..|.:.|...||.|           ...||               |:.||..:...:.|:|
Human    56 LSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAAW---------------RVWNLNHLWGRLRDFY 105

  Fly    85 SDVLNYSLSDFSKPDLQR-----IAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQ 144
            .:.|...:.. ..||||.     ::|:. :.:||.:|:|:||.:|.|..::.:|..|..|..|:|
Human   106 QEELQLLILS-PPPDLQTLGFDPLSEEA-VEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQ 168

  Fly   145 ANIMRALQELEATRQASTPEGGVASSLS---------------RGSRTGLLDSKAVQEDRDALAQ 194
            :.:..|:||:      :.|..||..:||               ..|..|.| ||..:| ||..||
Human   169 SELAAAIQEV------TQPGAGVVLALSGPDPGELAPAELEMLSRSLMGTL-SKLARE-RDLGAQ 225

  Fly   195 KCFETEKKMLLLIDEKTNLQQEL----------HKLQQEFARLEQHSTVIGDDGVSLGPVQTGSV 249
            :..|     |||..|...|:.|.          |.|..:.|                    ....
Human   226 RLAE-----LLLEREPLCLRPEAPSRAPAEGPSHHLALQLA--------------------NAKA 265

  Fly   250 RYNELRRQLDLLKEELLQSEGAREDL--KIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDV 312
            :...||::|:...|.||.|:...:.|  :|:..:|:...|..|.:..||.:..||  .|::....
Human   266 QLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAE--ALRERAGR 328

  Fly   313 LRESNDKLKICEAQL---DTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQ 374
            |....::|:.|..:|   :.||.:||:...|.   .:||...|...:|.....|...|...|:.:
Human   329 LPRLQEELRRCRERLQAAEAYKSQLEEERVLS---GVLEASKALLEEQLEAARERCARLHETQRE 390

  Fly   375 VELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRAKD---------SLLKERDNLREA 430
            ..|.:..:.:.||:||:...:..:|..:|..||   |.|||:.:         .|.....:|::.
Human   391 NLLLRTRLGEAHAELDSLRHQVDQLAEENVELE---LELQRSLEPPPGSPGEAPLAGAAPSLQDE 452

  Fly   431 VDELKCGQLSSNTALTGTTVSRELQPSATVEKLQRLEAENKALR------EGQ-GGQTALAQLLD 488
            |.|.:.|                        :|:.||.||:.||      :|| |||..|.:
Human   453 VREAEAG------------------------RLRTLERENRELRGLLQVLQGQPGGQHPLLE--- 490

  Fly   489 DANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEEAVTQST 553
                                      :..:||:|.                    .||||
Human   491 --------------------------APREDPVLP--------------------VLEEA----- 504

  Fly   554 SLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSIDPRIASALDASVLEKSAD---LVE 615
                            .|..:.:|...:..|:||::...........||| ||||.||:   ..:
Human   505 ----------------PQTPVAFDHSPQGLVQKARDGGPQALDLAPPALD-SVLEASAECPQAPD 552

  Fly   616 EEPKPKMSVMEEQLM 630
            .:|:...|.::...|
Human   553 SDPQEAESPLQAAAM 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK	8..675	CDD:283312	150/665 (23%)
CCDC88B	XP_011543259.1	SMC_prok_B	<259..964	CDD:274008	89/432 (21%)
		TMEM119	<520..669	CDD:292352	14/49 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840