DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hook and zyg-12

DIOPT Version :9

Sequence 1:	NP_476573.1	Gene:	hook / 35169	FlyBaseID:	FBgn0001202	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001293519.1	Gene:	zyg-12 / 24105291	WormBaseID:	WBGene00006997	Length:	777	Species:	Caenorhabditis elegans

Alignment Length:	746	Identity:	161/746 - (21%)
Similarity:	300/746 - (40%)	Gaps:	145/746 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WFKTLN-LNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQ 78
            |.:.|: ...|..|.:.|.:|.|.::.|:......|||.||..:..:.. :|..:..|..:|:.:
Worm    53 WMEGLDATKLPLNDPQLLCNGRAFSEVLHNVDKNFFTDGWLETMPENRT-TNIMVFRSCTRKLWR 116

  Fly    79 SVYDYYSDVLNYSLSDFSKPDLQRIAEKCD-LGELERLLQLVLGCAV--------NCAEKQSYIT 134
            .::||.:.: |.::......|   |.|:.| :.|.:....:.||.||        |......|..
Worm   117 KMFDYVNHI-NRTVVSSRWTD---IHERIDGIYESDLPAMVNLGMAVVTLAHIGKNAKRFVDYSK 177

  Fly   135 EIMCLEEELQANIMR-------ALQELEATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDAL 192
            .:....:.:.:|:.:       .:.|.....:.|...|..:...|....:|.|:.....|.|...
Worm   178 ALTSTHKSMMSNVAKMVTTVIDEMPENPCFHEISELHGSQSELNSLSESSGKLNGNGSSERRSNA 242

  Fly   193 AQKCFETEKKMLLLIDEKTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQ 257
            .|...:.|.::..|..|..|.::|:.:|.:.| ...||......:.   |.:.....:..|||::
Worm   243 DQILVDAELEIERLRTETENQRKEIERLTKSF-ETAQHDMSSNSES---GDISILEKQNEELRQK 303

  Fly   258 LDLLKEELLQSEGAREDLKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKI 322
            ...|:|:.|:.:.|.:..|                        ..|..|.:|.||||.|:.:.:.
Worm   304 RRELEEKNLELDAAVDQFK------------------------GIVFELTNENDVLRRSDKERQR 344

  Fly   323 CEAQLDTYKKKLEDY----NDLKKQVKILEERS---ADYVQQNAQFE------------EDAKR- 367
            .:..||..:..|:::    |..:|:.::.:::.   .:.:.||...:            |||.:
Worm   345 LQTVLDAAQSDLDEWKTVANQYQKEAELSKQQDKEIKELLSQNKALKSRLDHHVKSATLEDANKN 409

  Fly   368 -YANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNKNLESKNLALQRAKDSLLKERDNL---- 427
             .|..:.||........:|.|.||::.....:||......:.|...|:..||.|::||:.|
Worm   410 GIAQLRTQVGGLTALNTELKASLDSKKRCVEQLEIQLIQHKEKVKELEDRKDELIEERNRLENQL 474

  Fly   428 --REAV-------DELKCGQLSSNTALTGTTVSRELQPSATVEKLQRLEA------ENKALREGQ 477
              :|||       ...:.|.||........|:..|::.....|::|.||:      |...|:...
Worm   475 IFKEAVTPRSLHESMFEAGNLSFEPFSEKNTLPLEIENKRLTERIQELESLEPLKGELITLKSKN 539

  Fly   478 GGQTALAQLLDD----ANKRCENLREQLKTANERIL-SLSHASQSDDPILKESEFGKQIKQLMEL 537
            |       :|::    |.|:.|.|::|::...|.:| :..||  |.|.:      |.:|:  :|.
Worm   540 G-------VLEEEKLFATKQIEELQQQIEDLQENLLKNQEHA--SGDVV------GLKIQ--LEK 587

  Fly   538 NEQKTLQLEEAVTQSTSLQCKVTQLETNLSAREQEILVYDAKYRKCVEKAKEVIKSID--PRIAS 600
            .|.:..|:.||..::.:.|.:|.::   |..|..|:.|    ....::|||.||..::  .|..|
Worm   588 AEVEAQQMREAKMRAETNQAQVDEI---LKKRTAELEV----NATALQKAKAVIDELEYNSRPVS 645

  Fly   601 ALDASVLEKSADLVEEEPKPKMSV---------------MEEQLMTSAFYRLGVNAQRDAIDSKL 650
            ....:.::...::.||..|.:..|               .|.:|:|||.::..:|.   :||..:
Worm   646 EDSMTSVQAFKEMKEENEKLRQKVEKLEIELNTVTQGFEQENRLLTSASHQQVLNR---SIDEVM 707

  Fly   651 AILMGSG----QTFLARQRQSA--PRKSLSA 675
            ::...:|    ||.|..|:.|.  |.:||::
Worm   708 SMRAHAGSEEPQTLLDTQKMSGALPWRSLAS 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK	8..675	CDD:283312	161/744 (22%)
zyg-12	NP_001293519.1	eIF-4B	<243..318	CDD:283846	17/78 (22%)
		TACC	278..464	CDD:282818	42/212 (20%)
		MreC	<651..>704	CDD:302802	10/55 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4109
OMA	1	1.010	-	-		QHG53505
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001903
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101918
Panther	1	1.100	-	-	LDO	PTHR18947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.800