Protein Alignment hook and Hook2

DIOPT Version :10

• Sequence 1: NP_476573.1
• Gene: hook / 35169
• FlyBaseID: FBgn0001202
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_036009672.1
• Gene: Hook2 / 170833
• MGIID: 2181664
• Length: 833
• Species: Mus musculus
• Alignment Length: 763
• Identity: 212/763 - (27%)
• Similarity: 374/763 - (49%)
• Gaps: 134/763 - (17%)

  Fly    17 KTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVY 81
            :|..::.|.|..:.|:.|:|:|..|||..|..|.:.||..|...: ..:|||::..|:|:.||:.
Mouse    68 QTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISEDS-SPSWRLKVRKLEKILQSLV 131

  Fly    82 DYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQAN 146
            :|..:||.:.:||...||:..|.|..:..||.:|||||||||::|.:||.||..||.|||.:|..
Mouse   132 EYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLGCAISCEKKQEYIQRIMTLEESVQHV 196

  Fly   147 IMRALQEL--EATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDE 209
            :|.|:|||  :.|..:.:||.  ..:....||.....|:.|:|. |.|.|...:.|:::|||.:|
Mouse   197 VMEAIQELMTKDTPDSLSPEN--YGNFDTQSRRYYFLSEEVEEG-DHLQQHYLDLERQLLLLSEE 258

  Fly   210 KTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGARED 274
            |.||.||...|::...|.|          |...|..|.. :...|:.||:.|:||..:.|.:|||
Mouse   259 KQNLAQENAALRERVGRSE----------VESAPGLTAK-KLLLLQSQLEQLQEENFRLESSRED 312

  Fly   275 LKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYND 339
            .:::..:.:.::..:|.|.:.|...|.|...||||:|.||:|:::.:..||.|::.:::|.:..:
Mouse   313 DRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQE 377

  Fly   340 LKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNK 404
            |::||:.||||:|.:.::..|.||:.:|..:.:.|:|..::::|:|..:...|:.|..|..|:.:
Mouse   378 LRRQVRQLEERNAGHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGQWQEEAMKAEKWLFECR 442

  Fly   405 NLESKNLALQRAKDSLLKERDNLREAVDELKCGQL------SSNTALTGT-----TVSRELQPSA 458
            |||.|...:.:.|:.||.|||:||||.:||:|.||      .::.:|..|     .::.|:.|:.
Mouse   443 NLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAE 507

  Fly   459 TVEKLQRLEAENKALREGQGG----QTALAQLLDDANKRCENLREQLKTANERILSLS------- 512
            ..|.|.||:.|||.|.:.:..    |..|.:.|::||:....|..|.:...:::..|.
Mouse   508 LRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQ 572

  Fly   513 ------------------------------------------------HASQ----------SD- 518
                                                            |.|:          ||
Mouse   573 KALQEQGGKTEDVSACLLPAWPSLVLPSNPPFSLPPCCPMPEEGHCEYHGSREAHHCYLHSFSDL 637

  Fly   519 ------------DPILKESEFGKQIKQL----MELNEQKTL--QLEEAVTQSTSLQCKVTQLETN 565
                        .|.|.:.:....:::|    :||..::..  :||.....||:.  ::.:|:.:
Mouse   638 VPVPSLPAASLPQPTLLKRKLEDHLQKLHEADLELQRKREYIEELEPPTDSSTAR--RIEELQDS 700

  Fly   566 LSAREQEILVYDAKYRKCVEKAKEVIKSIDPR-----IAS----ALDASVLEKSADL----VEEE 617
            |..::.::...:.:||:.|:||:.||::::|:     :.|    .|.:.:.|::..:    ::.|
Mouse   701 LQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYE 765

  Fly   618 PKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQR 665
            ...:....||:|:.||:|.:|:..:..|.:....   ...|:|||:||
Mouse   766 KSRRRQEQEEKLLISAWYSMGMALEHRAGEEHAP---AHAQSFLAQQR 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK_N	7..158	CDD:465958	58/142 (41%)
		HOOK	181..674	CDD:461694	149/597 (25%)
Hook2	XP_036009672.1	HkD_SF	67..207	CDD:425405	58/139 (42%)
		HOOK	230..819	CDD:461694	149/598 (25%)