DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hook and Hook2

DIOPT Version :9

Sequence 1:	NP_476573.1	Gene:	hook / 35169	FlyBaseID:	FBgn0001202	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_036009672.1	Gene:	Hook2 / 170833	MGIID:	2181664	Length:	833	Species:	Mus musculus

Alignment Length:	763	Identity:	212/763 - (27%)
Similarity:	374/763 - (49%)	Gaps:	134/763 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KTLNLNAPHADAESLADGVALAQALNQFAPESFTDAWLSKIKASAVGSNWRLRMSNLKKVTQSVY 81
            :|..::.|.|..:.|:.|:|:|..|||..|..|.:.||..|...: ..:|||::..|:|:.||:.
Mouse    68 QTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISEDS-SPSWRLKVRKLEKILQSLV 131

  Fly    82 DYYSDVLNYSLSDFSKPDLQRIAEKCDLGELERLLQLVLGCAVNCAEKQSYITEIMCLEEELQAN 146
            :|..:||.:.:||...||:..|.|..:..||.:|||||||||::|.:||.||..||.|||.:|..
Mouse   132 EYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLGCAISCEKKQEYIQRIMTLEESVQHV 196

  Fly   147 IMRALQEL--EATRQASTPEGGVASSLSRGSRTGLLDSKAVQEDRDALAQKCFETEKKMLLLIDE 209
            :|.|:|||  :.|..:.:||.  ..:....||.....|:.|:|. |.|.|...:.|:::|||.:|
Mouse   197 VMEAIQELMTKDTPDSLSPEN--YGNFDTQSRRYYFLSEEVEEG-DHLQQHYLDLERQLLLLSEE 258

  Fly   210 KTNLQQELHKLQQEFARLEQHSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGARED 274
            |.||.||...|::...|.|          |...|..|.. :...|:.||:.|:||..:.|.:|||
Mouse   259 KQNLAQENAALRERVGRSE----------VESAPGLTAK-KLLLLQSQLEQLQEENFRLESSRED 312

  Fly   275 LKIKAQQQDTDLLHMQMRIEELMKSSAEVTTLKDEVDVLRESNDKLKICEAQLDTYKKKLEDYND 339
            .:::..:.:.::..:|.|.:.|...|.|...||||:|.||:|:::.:..||.|::.:::|.:..:
Mouse   313 DRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQE 377

  Fly   340 LKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAKLDAESSKNVKLEFDNK 404
            |::||:.||||:|.:.::..|.||:.:|..:.:.|:|..::::|:|..:...|:.|..|..|:.:
Mouse   378 LRRQVRQLEERNAGHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGQWQEEAMKAEKWLFECR 442

  Fly   405 NLESKNLALQRAKDSLLKERDNLREAVDELKCGQL------SSNTALTGT-----TVSRELQPSA 458
            |||.|...:.:.|:.||.|||:||||.:||:|.||      .::.:|..|     .::.|:.|:.
Mouse   443 NLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAE 507

  Fly   459 TVEKLQRLEAENKALREGQGG----QTALAQLLDDANKRCENLREQLKTANERILSLS------- 512
            ..|.|.||:.|||.|.:.:..    |..|.:.|::||:....|..|.:...:::..|.
Mouse   508 LRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQ 572

  Fly   513 ------------------------------------------------HASQ----------SD- 518
                                                            |.|:          ||
Mouse   573 KALQEQGGKTEDVSACLLPAWPSLVLPSNPPFSLPPCCPMPEEGHCEYHGSREAHHCYLHSFSDL 637

  Fly   519 ------------DPILKESEFGKQIKQL----MELNEQKTL--QLEEAVTQSTSLQCKVTQLETN 565
                        .|.|.:.:....:::|    :||..::..  :||.....||:.  ::.:|:.:
Mouse   638 VPVPSLPAASLPQPTLLKRKLEDHLQKLHEADLELQRKREYIEELEPPTDSSTAR--RIEELQDS 700

  Fly   566 LSAREQEILVYDAKYRKCVEKAKEVIKSIDPR-----IAS----ALDASVLEKSADL----VEEE 617
            |..::.::...:.:||:.|:||:.||::::|:     :.|    .|.:.:.|::..:    ::.|
Mouse   701 LQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYE 765

  Fly   618 PKPKMSVMEEQLMTSAFYRLGVNAQRDAIDSKLAILMGSGQTFLARQR 665
            ...:....||:|:.||:|.:|:..:..|.:....   ...|:|||:||
Mouse   766 KSRRRQEQEEKLLISAWYSMGMALEHRAGEEHAP---AHAQSFLAQQR 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hook	NP_476573.1	HOOK	8..675	CDD:283312	212/763 (28%)
Hook2	XP_036009672.1	HOOK_N	67..208	CDD:408817	58/140 (41%)
Hook2	XP_036009672.1	HOOK	230..819	CDD:398962	149/598 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831631
Domainoid	1	1.000	387	1.000	Domainoid score	I797
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1983
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373785at33208
OrthoFinder	1	1.000	-	-		FOG0001903
OrthoInspector	1	1.000	-	-		otm43900
orthoMCL	1	0.900	-	-		OOG6_101918
Panther	1	1.100	-	-	O	PTHR18947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2196
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860