DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sidpn and Bhlhe40

DIOPT Version :10

Sequence 1:NP_523599.1 Gene:Sidpn / 35168 FlyBaseID:FBgn0032741 Length:507 Species:Drosophila melanogaster
Sequence 2:NP_445780.2 Gene:Bhlhe40 / 79431 RGDID:68439 Length:411 Species:Rattus norvegicus


Alignment Length:467 Identity:102/467 - (21%)
Similarity:157/467 - (33%) Gaps:168/467 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 STQNVTSSQDISKRTNK---PLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEK 100
            |.:.:..|:| ||.|.|   .|:||:||.|||:.:|.||.|:.|..|.....:         |||
  Rat    39 SRRGIKRSED-SKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH---------LEK 93

  Fly   101 ADILELTVRHFQRHRNLDDPTVNKYRA------------------------GYTDCAREVARYLA 141
            |.:||||::|.:...||.|....|..|                        |:..|||||.:|||
  Rat    94 AVVLELTLKHVKALTNLIDQQQQKIMALQSGLQAGDLSGRNIEAGQEMFCSGFQTCAREVLQYLA 158

  Fly   142 TPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNHGKKSQP 206
            ..|.         ......::|:.||.:.::|:            .:..:|....|      |.|
  Rat   159 KHEN---------TRDLKSSQLVTHLHRVVSEL------------LQGSASRKPLD------SAP 196

  Fly   207 EEHSLDYSSQDSNPVDYSK------------GLKMVAAEQRTLPVTPAPQ---DENNNRGLQAQA 256
            :            |||:.:            |...|...|||...:...|   |.:.:.|...:.
  Rat   197 K------------PVDFKEKPSFLAKGSEGPGKNCVPVIQRTFAPSGGEQSGSDTDTDSGYGGEL 249

  Fly   257 QTPIPIQVQSQTQGQTSPH------VDAVAPSELSYEEDRNKVCANVLEQYKQQLKAHVQQQPES 315
            :..   .::|:.....|.|      .:.|:..:...||...|             |:.:|...|.
  Rat   250 EKG---DLRSEQPYFKSDHGRRFTVGERVSTIKQESEEPPTK-------------KSRMQLSDEE 298

  Fly   316 ANGVLVLPPHYVQLAAALGLSAQPLVDPIATRTDFERLIELQRVQPHLAGKLSPSF--PGGLEAA 378
            .        |:|    ...|...|.:.|                .||     .|.|  |..|   
  Rat   299 G--------HFV----GSDLMGSPFLGP----------------HPH-----QPPFCLPFYL--- 327

  Fly   379 HVAAAAAAYANSM--------------AVAASAGASVAAMATSGAGTPTVHQER-PASVA-ASVS 427
             :..:|.||...:              .:..||.|..:.|......||.:..:| |:.:| :|:.
  Rat   328 -IPPSATAYLPMLEKCWYPTSVPLLYPGLNTSAAALSSFMNPDKIPTPLLLPQRLPSPLAHSSLD 391

  Fly   428 SGVSMSELKSMP 439
            |...:..||.:|
  Rat   392 SSALLQALKQIP 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SidpnNP_523599.1 bHLH_O_HES 58..116 CDD:381416 22/57 (39%)
Hairy_orange 124..172 CDD:462193 15/71 (21%)
Bhlhe40NP_445780.2 Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250 1..139 35/109 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
bHLH-O_DEC1 40..129 CDD:381592 34/98 (35%)
Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250 75..79 2/3 (67%)
ORANGE 140..184 CDD:128787 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..293 23/140 (16%)
Blue background indicates that the domain is not in the aligned region.

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