DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sidpn and BHLHE41

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens

Alignment Length:	502	Identity:	114/502 - (22%)
Similarity:	180/502 - (35%)	Gaps:	131/502 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QDISKRTNK---PLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTV 108
            :|.:|.|.|   .|:||:||.|||:.:|.||.|:.|..|.....:         ||||.:||||:
Human    38 RDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH---------LEKAVVLELTL 93

  Fly   109 RHF--------QRH----------RNLDDP---TVNKYRAGYTDCAREVARYLA-----TPEPPP 147
            :|.        |:|          |:|..|   .::.:.:|:..||:||.:||:     ||..|.
Human    94 KHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPR 158

  Fly   148 MGTMPTLAEPGSKARLLRHLDQCIAEI---------DVEICPHSTAAFAESPSSSSCFDLNHGKK 203
            .            .:|:.||.....:.         .|.:...:.|..|...:::.|
Human   159 C------------VQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPC-------- 203

  Fly   204 SQPEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPVT--PAPQDENNNRGLQAQAQTPIPIQVQS 266
                   |:.:.|...|:.|     .|...|||.|..  .|..|.:.:.|...:|:.. |.:.:.
Human   204 -------LERAGQKLEPLAY-----CVPVIQRTQPSAELAAENDTDTDSGYGGEAEAR-PDREKG 255

  Fly   267 QTQG-------QTSPHVDAVAPSELSYEE-----------DRNKVCANVLEQYKQQLKAHVQQQP 313
            :..|       |..|..|:.||..:..:.           ......|.:|             .|
Human   256 KGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALL-------------GP 307

  Fly   314 ESANGVLVLPPHYVQLAAAL---GLSAQPLVDPIATRTDFERLIELQRVQPHLAGKLSPSF--PG 373
            :.|....:|.|....|::.:   |....|...|.|....|  .:....:.|..|......|  ..
Human   308 DPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPF--CLPFCFLSPSAAAAYVQPFLDKS 370

  Fly   374 GLEAAHVAAAAAA-----YANSMAVAASAGASVAAMATSGAGTPTVHQ--ERPASVAASVSSGVS 431
            |||.....|||||     |....|.||:|.|:.|| |.:.|..|.:..  ..|...|.:.::.:.
Human   371 GLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAA-AAAAAAFPCLSSVLSPPPEKAGAAAATLL 434

  Fly   432 MSELKSMPATQQSSPRSESGI---GSNENEAPATSPRPQTSNAARQA 475
            ..|:..:.|.....|...:.:   |..|...|.:|.:...|...::|
Human   435 PHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKEA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	30/89 (34%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	13/51 (25%)
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	31/92 (34%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		2/3 (67%)
		ORANGE	129..175	CDD:128787	13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298		11/70 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482		8/44 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910