DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and hey2

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_571697.2	Gene:	hey2 / 58146	ZFINID:	ZDB-GENE-000526-1	Length:	324	Species:	Danio rerio

Alignment Length:	418	Identity:	92/418 - (22%)
Similarity:	150/418 - (35%)	Gaps:	162/418 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AGSTNGSGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKALILESTKTQNAK 87
            :|.:|||.|:      .....|:||.::::..:.::|||||.|||.||:.|:.|:..:.:.|.:
Zfish    27 SGQSNGSFIR------CGSPTTTSQVMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS- 84

  Fly    88 NGEGQAKHTKLEKADILELTVRH------------FQRHRNLDDPTVNKYRAGYTDCAREVARYL 140
                    .|||||:||::||.|            |..|    ...::....|:.:|..||||||
Zfish    85 --------AKLEKAEILQMTVDHLKMLQATGGKGYFDAH----SLAMDFLSIGFRECLTEVARYL 137

  Fly   141 ATPE----PPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNHG 201
            ::.|    ..|:           :.||:.||..|.::       ...||...
Zfish   138 SSVEGLDSSDPL-----------RVRLVSHLSSCASQ-------REAAAMTT------------- 171

  Fly   202 KKSQPEEHSLDYSSQDSNPVDYSKGLKMVAA---EQRTLP--------VTPAPQDENNNRGLQAQ 255
                    |:.:..|..:|..::..|..:.|   :|..||        ::.|||     ||....
Zfish   172 --------SIAHHQQALHPHHWAAALHPIPAAFLQQSGLPSSESSSGRLSEAPQ-----RGAALF 223

  Fly   256 AQTPIPIQVQSQTQGQTSPHVDAVAPSELSYEEDRNKVCANVLEQYKQQLKAHVQQQPESANGVL 320
            :.:...::..|  .|..:|.|..::.|.||                   |.|.|.
Zfish   224 SHSDSALRAPS--TGSVAPCVPPLSTSLLS-------------------LSATVH---------- 257

  Fly   321 VLPPHYVQLAAALGLSAQ--PLVDPIATRTDFERLIELQRVQPHLAGKLSPSFPGGLEAAHVAAA 383
                     |||...:||  ||                             |||.|......:..
Zfish   258 ---------AAAAAAAAQTFPL-----------------------------SFPAGFPLFSPSVT 284

  Fly   384 AAAYANSMAVAASAGASVAAMATSGAGT 411
            |::.|:| .|::|...|..:..:||:.:
Zfish   285 ASSVASS-TVSSSVSTSTTSQQSSGSSS 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	25/80 (31%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	15/50 (30%)
hey2	NP_571697.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		3/6 (50%)
		HLH	49..105	CDD:238036	23/64 (36%)
		Hairy_orange	125..162	CDD:284859	15/47 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..324		4/18 (22%)
		YRPW motif	314..317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810