DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sidpn and Heyl

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_038933.2	Gene:	Heyl / 56198	MGIID:	1860511	Length:	326	Species:	Mus musculus

Alignment Length:	364	Identity:	84/364 - (23%)
Similarity:	132/364 - (36%)	Gaps:	120/364 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SQDISKRTNKPLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRH 110
            ||..:::..:.::|||||.|||.||:.|:.|:..:.:.|.:         :|||||::|::||.|
Mouse    39 SQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS---------SKLEKAEVLQMTVDH 94

  Fly   111 -----------FQRHRNLDDPTVNKYRAGYTDCAREVARYLATPEPPPMGTMPTLAEPGSKARLL 164
                       |...|.|   .|:....|:.:|..||.|||...|.|.....|.      :.|||
Mouse    95 LKMLHASGGTGFFDARAL---AVDFRSIGFRECLTEVIRYLGVLEGPSSHADPV------RIRLL 150

  Fly   165 RHLDQCIAEIDVEICPHSTAAFAESPSS--SSCFDLNHGKKSQPEEHSLDYSSQDSNPVDYSKGL 227
            .||....||::......|..||...|.|  .||                             .||
Mouse   151 SHLKSYAAEMEPSPTTTSALAFPVWPWSFLHSC-----------------------------PGL 186

  Fly   228 KMVAAEQRTLPVTPAPQDENNNRGLQAQAQTPIPIQVQSQTQGQTSP-HVDA--VAPSELSYEED 289
            ..:.::...|...|.|.       |.:.:..|.||...     :::| |..|  :.|:..:....
Mouse   187 PSLNSQLAILGRVPGPV-------LPSISSPPYPISAL-----RSAPVHRPAGTIPPTRRNLLPS 239

  Fly   290 RNKVCANVLEQYKQQLKAHVQQQP----------ESANGVLVLPPHYVQLAAALGLSAQPLVDPI 344
            |......         :||:.::|          .:|..::.:||            ..|...|.
Mouse   240 RGVTSTQ---------RAHLPERPAAPPPTALDARAARSIVPIPP------------CSPTTAPG 283

  Fly   345 ATRTDFERLIELQRVQPHLAGKLS---PSFPGGLEAAHV 380
            |.::|           .:::|.:|   ||.|.|..|..|
Mouse   284 AGKSD-----------DNVSGSISSPCPSGPTGRPAGAV 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	24/79 (30%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	15/46 (33%)
Heyl	NP_038933.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		5/16 (31%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		23/77 (30%)
		HLH	44..100	CDD:238036	22/64 (34%)
		ORANGE	115..162	CDD:128787	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..260		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..306		11/56 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740