DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and HES2

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_061962.2	Gene:	HES2 / 54626	HGNCID:	16005	Length:	173	Species:	Homo sapiens

Alignment Length:	177	Identity:	63/177 - (35%)
Similarity:	82/177 - (46%)	Gaps:	33/177 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KRTNKPLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHR 115
            :::.|||:||||||||||||:.||.|||.....:|       :..:||||||:||:|||..|...
Human    14 RKSLKPLLEKRRRARINQSLSQLKGLILPLLGREN-------SNCSKLEKADVLEMTVRFLQELP 71

  Fly   116 NLDDPTV-----NKYRAGYTDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHL--DQCIAE 173
            ....||.     :.||.||:.|...:||.|....         :.||...||||.||  ....|.
Human    72 ASSWPTAAPLPCDSYREGYSACVARLARVLPACR---------VLEPAVSARLLEHLWRRAASAT 127

  Fly   174 IDVEICPHSTAAFAESPSSSSCFDLNHGKKSQPEEHSLDYSSQDSNP 220
            :|......|:...|.:|:.:|.          ||..|....|..|.|
Human   128 LDGGRAGDSSGPSAPAPAPASA----------PEPASAPVPSPPSPP 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	33/65 (51%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	16/48 (33%)
HES2	NP_061962.2	HLH	12..70	CDD:238036	33/62 (53%)
		ORANGE	84..127	CDD:128787	16/51 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..173		11/47 (23%)
		WRPW motif	170..173
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880