DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sidpn and hes1

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001011194.1	Gene:	hes1 / 496617	XenbaseID:	XB-GENE-487995	Length:	267	Species:	Xenopus tropicalis

Alignment Length:	318	Identity:	96/318 - (30%)
Similarity:	135/318 - (42%)	Gaps:	114/318 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KNKSAPGIGFTAAGSTNGSGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKA 75
            ||.|:| :..|.|.            :|:|.:...:....::::||:||||||||||:||..||.
Frog     8 KNSSSP-VAATPAS------------MSNTPDKPKTASEHRKSSKPIMEKRRRARINESLGQLKT 59

  Fly    76 LILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLD----------DPTV-NKYRAGY 129
            |||::.|       :..::|:|||||||||:||:|.   |||.          ||:| .|||||:
Frog    60 LILDALK-------KDSSRHSKLEKADILEMTVKHL---RNLQRVQMTAALSTDPSVLGKYRAGF 114

  Fly   130 TDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEID-----------VEICPHST 183
            ::|..||.|:|:|.|.         .....:.|||.||..|:.:|:           ....||..
Frog   115 SECMNEVTRFLSTCEG---------VNTDVRTRLLGHLANCMNQINAMNYPTQPQIPAAAAPHPA 170

  Fly   184 ----------AAFAESPSSSSCFDLNHGKKSQPEEHSLDYSSQDSNPVDYSK---GLKMVAAEQR 235
                      ||...||:..:|      |...|             ||:.:|   |.::|.|...
Frog   171 YGQPLVQLQGAAPQSSPAPIAC------KMGGP-------------PVEAAKVYGGFQLVPAPDG 216

  Fly   236 ------TLPVTP-----APQDENNNRGLQAQAQTPIPIQVQSQTQGQTSPHVDAVAPS 282
                  |.|..|     .|...|:|.|      |.:|..|        ||   :|.||
Frog   217 QFAFLITNPAFPHNGSVIPVYTNSNVG------TALPPSV--------SP---SVMPS 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	34/68 (50%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	17/46 (37%)
hes1	NP_001011194.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		12/49 (24%)
		bHLH-O_HES1_4	33..95	CDD:381465	36/71 (51%)
		Hairy_orange	110..148	CDD:369405	17/46 (37%)
		WRPW motif. /evidence=ECO:0000255	264..267
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020