DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and HES3

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001019769.1	Gene:	HES3 / 390992	HGNCID:	26226	Length:	186	Species:	Homo sapiens

Alignment Length:	188	Identity:	54/188 - (28%)
Similarity:	77/188 - (40%)	Gaps:	57/188 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 MEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLDD--- 119
            |||:||||||.||..||:|:        .|:...|.:..||||||||||:|::.   |:|.:
Human     1 MEKKRRARINVSLEQLKSLL--------EKHYSHQIRKRKLEKADILELSVKYM---RSLQNSLQ 54

  Fly   120 -----PTVNKYRAGYTDCAREVARYL-------------ATPEPPPMGTMPTLAEPGSKARLLRH 166
                 |...:..:|:..|...|::.|             ..||.....||.: |..|.:|..|
Human    55 GLWPVPRGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDS-AGLGQEAPAL-- 116

  Fly   167 LDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNHGKKSQPE----EHSLDYSSQDSNP 220
                       ..|.:.|.:|.:|::.       |.:|.|.    ..||..||....|
Human   117 -----------FRPCTPAVWAPAPAAG-------GPRSPPPLLLLPESLPGSSASVPP 156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	28/58 (48%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	12/59 (20%)
HES3	NP_001019769.1	HLH	1..54	CDD:238036	29/63 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..186		9/36 (25%)
		WRPW motif	175..178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910