DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and HES1

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_005515.1	Gene:	HES1 / 3280	HGNCID:	5192	Length:	280	Species:	Homo sapiens

Alignment Length:	308	Identity:	93/308 - (30%)
Similarity:	134/308 - (43%)	Gaps:	87/308 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KNKSAPGIGFTAAGSTNGSGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKA 75
            ||.|:| :..|.|.            |::|.:...:....::::||:||||||||||:||:.||.
Human     8 KNSSSP-VAATPAS------------VNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKT 59

  Fly    76 LILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLD----------DPTV-NKYRAGY 129
            |||::.|       :..::|:|||||||||:||:|.   |||.          ||:| .|||||:
Human    60 LILDALK-------KDSSRHSKLEKADILEMTVKHL---RNLQRAQMTAALSTDPSVLGKYRAGF 114

  Fly   130 TDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEIC---PHST-------- 183
            ::|..||.|:|:|.|    |....:     :.|||.||..|:.:|:....   ||..
Human   115 SECMNEVTRFLSTCE----GVNTEV-----RTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPP 170

  Fly   184 --------AAFAESPSSSSCFDLNHGKKSQPEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPVT 240
                    |.||..|   ....:..|....|........||.........|.::|
Human   171 PGPGGPQHAPFAPPP---PLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVV---------- 222

  Fly   241 PAPQDE------NNNRGLQAQAQTPIPIQVQSQTQGQTSPHVDAVAPS 282
            |||..:      |   |..|.:...||:..   :...||...:||:||
Human   223 PAPDGQFAFLIPN---GAFAHSGPVIPVYT---SNSGTSVGPNAVSPS 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	34/68 (50%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	18/46 (39%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		11/48 (23%)
		bHLH-O_HES1_4	33..95	CDD:381465	36/71 (51%)
		Hairy_orange	110..148	CDD:400076	18/46 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..200		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..280		6/11 (55%)
		WRPW motif	275..278
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920