DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and Hes1

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_077336.3	Gene:	Hes1 / 29577	RGDID:	62081	Length:	281	Species:	Rattus norvegicus

Alignment Length:	309	Identity:	92/309 - (29%)
Similarity:	133/309 - (43%)	Gaps:	88/309 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KNKSAPGIGFTAAGSTNGSGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKA 75
            ||.|:| :..|.|.            |::|.:...:....::::||:||||||||||:||:.||.
  Rat     8 KNSSSP-VAATPAS------------VNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKT 59

  Fly    76 LILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLD----------DPTV-NKYRAGY 129
            |||::.|       :..::|:|||||||||:||:|.   |||.          ||:| .|||||:
  Rat    60 LILDALK-------KDSSRHSKLEKADILEMTVKHL---RNLQRAQMTAALSTDPSVLGKYRAGF 114

  Fly   130 TDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPHST----------- 183
            ::|..||.|:|:|.|    |....:     :.|||.||..|:.:|:....|...
  Rat   115 SECMNEVTRFLSTCE----GVNTEV-----RTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPP 170

  Fly   184 ---------AAFAESPSSSSCFDLNHGKKSQPEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPV 239
                     |.||..|   ....:..|....|........||.........|.::|
  Rat   171 PSGPGGPQHAPFAPPP---PLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVV--------- 223

  Fly   240 TPAPQDE------NNNRGLQAQAQTPIPIQVQSQTQGQTSPHVDAVAPS 282
             |||..:      |   |..|.:...||:..   :...||...:||:||
  Rat   224 -PAPDGQFAFLIPN---GAFAHSGPVIPVYT---SNSGTSVGPNAVSPS 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	34/68 (50%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	18/46 (39%)
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		11/48 (23%)
		bHLH-O_HES1_4	33..95	CDD:381465	36/71 (51%)
		Hairy_orange	110..148	CDD:400076	18/46 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..206		6/50 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..281		6/11 (55%)
		WRPW motif	276..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427802at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920