DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sidpn and Bhlhe40

DIOPT Version :9

Sequence 1:NP_523599.1 Gene:Sidpn / 35168 FlyBaseID:FBgn0032741 Length:507 Species:Drosophila melanogaster
Sequence 2:NP_035628.1 Gene:Bhlhe40 / 20893 MGIID:1097714 Length:411 Species:Mus musculus


Alignment Length:478 Identity:104/478 - (21%)
Similarity:163/478 - (34%) Gaps:144/478 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 APGIGFTAAGSTNGSGIKSIGLV-SSTQNVTSSQDISKRTNK---PLMEKRRRARINQSLAILKA 75
            |||:   ..|..:|.....:..| .|.:.:..|:| ||.|.|   .|:||:||.|||:.:|.||.
Mouse    17 APGL---EHGDLSGMDFAHMYQVYKSRRGIKRSED-SKETYKLPHRLIEKKRRDRINECIAQLKD 77

  Fly    76 LILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLDDPTVNK---------------- 124
            |:.|..|.....:         ||||.:||||::|.:...||.|....|                
Mouse    78 LLPEHLKLTTLGH---------LEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGR 133

  Fly   125 --------YRAGYTDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPH 181
                    :.:|:..|||||.:|||..|.         ......::|:.||.:.::|:       
Mouse   134 NLEAGQEMFCSGFQTCAREVLQYLAKHEN---------TRDLKSSQLVTHLHRVVSEL------- 182

  Fly   182 STAAFAESPSSSSCFDLNHGKKSQPEEHSLDYSSQDSNPVDYSKGLK-----MVAAEQRTLPVTP 241
                            |..|...:|.:.:.........|...:||.:     .|...|||...:.
Mouse   183 ----------------LQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFAPSG 231

  Fly   242 APQ---DENNNRGLQAQAQTPIPIQVQSQTQGQTSPHVDAVAPSELSYEEDRNKVCANVLEQYKQ 303
            ..|   |.:.:.|...:.:..   .::|:.....|.|....|..|.          .:.::|..:
Mouse   232 GEQSGSDTDTDSGYGGELEKG---DLRSEQPYFKSDHGRRFAVGER----------VSTIKQESE 283

  Fly   304 Q---LKAHVQQQPESANGVLVLPPHYVQLAAALGLSAQPLVDPIATRTDFERLIELQRVQPHLAG 365
            :   .|:.:|...|..        |:    |...|...|.:.|                .||   
Mouse   284 EPPTKKSRMQLSEEEG--------HF----AGSDLMGSPFLGP----------------HPH--- 317

  Fly   366 KLSPSF-------PGGLEAAHVAAAAAAYANSMAVA-----ASAGASVAAMATSGAGTPTVHQER 418
              .|.|       |....|.........|..|:.|.     .||.|..:.|......||.:..:|
Mouse   318 --QPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNTSAAALSSFMNPDKIPTPLLLPQR 380

  Fly   419 -PASVA-ASVSSGVSMSELKSMP 439
             |:.:| :|:.|...:..||.:|
Mouse   381 LPSPLAHSSLDSSALLQALKQIP 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SidpnNP_523599.1 HLH 48..117 CDD:238036 28/71 (39%)
Hairy_orange 125..172 CDD:284859 13/46 (28%)
Bhlhe40NP_035628.1 Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250 1..139 40/134 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 2/2 (100%)
bHLH-O_DEC1 40..129 CDD:381592 33/98 (34%)
Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250 75..79 2/3 (67%)
ORANGE 140..184 CDD:128787 14/75 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..294 16/99 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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