Protein Alignment Sidpn and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_523599.1
• Gene: Sidpn / 35168
• FlyBaseID: FBgn0032741
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_035628.1
• Gene: Bhlhe40 / 20893
• MGIID: 1097714
• Length: 411
• Species: Mus musculus
• Alignment Length: 478
• Identity: 104/478 - (21%)
• Similarity: 163/478 - (34%)
• Gaps: 144/478 - (30%)

  Fly    15 APGIGFTAAGSTNGSGIKSIGLV-SSTQNVTSSQDISKRTNK---PLMEKRRRARINQSLAILKA 75
            |||:   ..|..:|.....:..| .|.:.:..|:| ||.|.|   .|:||:||.|||:.:|.||.
Mouse    17 APGL---EHGDLSGMDFAHMYQVYKSRRGIKRSED-SKETYKLPHRLIEKKRRDRINECIAQLKD 77

  Fly    76 LILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQRHRNLDDPTVNK---------------- 124
            |:.|..|.....:         ||||.:||||::|.:...||.|....|
Mouse    78 LLPEHLKLTTLGH---------LEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGR 133

  Fly   125 --------YRAGYTDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPH 181
                    :.:|:..|||||.:|||..|.         ......::|:.||.:.::|:
Mouse   134 NLEAGQEMFCSGFQTCAREVLQYLAKHEN---------TRDLKSSQLVTHLHRVVSEL------- 182

  Fly   182 STAAFAESPSSSSCFDLNHGKKSQPEEHSLDYSSQDSNPVDYSKGLK-----MVAAEQRTLPVTP 241
                            |..|...:|.:.:.........|...:||.:     .|...|||...:.
Mouse   183 ----------------LQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFAPSG 231

  Fly   242 APQ---DENNNRGLQAQAQTPIPIQVQSQTQGQTSPHVDAVAPSELSYEEDRNKVCANVLEQYKQ 303
            ..|   |.:.:.|...:.:..   .::|:.....|.|....|..|.          .:.::|..:
Mouse   232 GEQSGSDTDTDSGYGGELEKG---DLRSEQPYFKSDHGRRFAVGER----------VSTIKQESE 283

  Fly   304 Q---LKAHVQQQPESANGVLVLPPHYVQLAAALGLSAQPLVDPIATRTDFERLIELQRVQPHLAG 365
            :   .|:.:|...|..        |:    |...|...|.:.|                .||
Mouse   284 EPPTKKSRMQLSEEEG--------HF----AGSDLMGSPFLGP----------------HPH--- 317

  Fly   366 KLSPSF-------PGGLEAAHVAAAAAAYANSMAVA-----ASAGASVAAMATSGAGTPTVHQER 418
              .|.|       |....|.........|..|:.|.     .||.|..:.|......||.:..:|
Mouse   318 --QPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNTSAAALSSFMNPDKIPTPLLLPQR 380

  Fly   419 -PASVA-ASVSSGVSMSELKSMP 439
             |:.:| :|:.|...:..||.:|
Mouse   381 LPSPLAHSSLDSSALLQALKQIP 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	bHLH_O_HES	58..116	CDD:381416	22/57 (39%)
		Hairy_orange	124..172	CDD:462193	14/71 (20%)
Bhlhe40	NP_035628.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		40/134 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		2/2 (100%)
		bHLH-O_DEC1	40..129	CDD:381592	33/98 (34%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	14/75 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..294		10/79 (13%)