DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and Hey2

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_038932.1	Gene:	Hey2 / 15214	MGIID:	1341884	Length:	339	Species:	Mus musculus

Alignment Length:	451	Identity:	101/451 - (22%)
Similarity:	161/451 - (35%)	Gaps:	165/451 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSTNG-SGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKALILESTKTQNAK 87
            ||.|. .|..:..::.|....|:||.::::..:.::|||||.|||.||:.|:.|:..:.:.|.:
Mouse    21 GSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS- 84

  Fly    88 NGEGQAKHTKLEKADILELTVRH------------FQRHRNLDDPTVNKYRAGYTDCAREVARYL 140
                    .|||||:||::||.|            |..|....|    ....|:.:|..||||||
Mouse    85 --------AKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATD----FMSIGFRECLTEVARYL 137

  Fly   141 ATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNHGKKSQ 205
            ::.|    |..|  ::| .:.||:.||..|.::.:..:...|.|              :|.....
Mouse   138 SSVE----GLDP--SDP-LRVRLVSHLSTCASQREAAVMTSSMA--------------HHHHPLH 181

  Fly   206 PEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPVTPAPQDENNNRGLQAQAQTPIPIQVQSQTQG 270
            |...                     ||....||......:     ||.....||..:...|:.
Mouse   182 PHHW---------------------AAAFHHLPTALLQPN-----GLHTSESTPCRLSTSSEV-- 218

  Fly   271 QTSPHVDAVAPSELSYEEDRNKVCANVLEQYKQQLKAHVQQQPESANGVLVLPPHYVQLAAALGL 335
             .|.|..|:..:..::                             |:..|.:|.         |.
Mouse   219 -PSAHGSALLTATFAH-----------------------------ADSALRMPS---------GG 244

  Fly   336 SAQPLVDPIATRTDFERLIELQRVQPHLAGKLSPSFPGGLEAAHVAAAAAA------YANSMAVA 394
            :..|.|.|::|     .|:.|...               :.||..||.|||      :|.:..:.
Mouse   245 TVAPCVPPLST-----SLLSLSAT---------------VHAAAAAATAAAHSFPLSFAGAFPML 289

  Fly   395 ASAGASVAAMATSGAGTPTVHQERPASVAASVSSGVSMSELKSMPATQQSSPRSESGIGSN 455
            .|..|:.||:|.:.|.:|      |.||:|:                  |||: ::..|:|
Mouse   290 PSNAAAAAAVAAATAISP------PLSVSAA------------------SSPQ-QTSTGTN 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	25/80 (31%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	17/46 (37%)
Hey2	NP_038932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		8/30 (27%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269\|PubMed:11486045	47..116		24/77 (31%)
		HLH	49..105	CDD:238036	23/64 (36%)
		ORANGE	120..165	CDD:128787	18/55 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..339		8/35 (23%)
		YQPW motif	329..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810