DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and Hey1

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_034553.2	Gene:	Hey1 / 15213	MGIID:	1341800	Length:	299	Species:	Mus musculus

Alignment Length:	381	Identity:	94/381 - (24%)
Similarity:	144/381 - (37%)	Gaps:	145/381 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 STNGSGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKALILESTKTQNAKNG 89
            |.:.:|..|..|.|.:. .||||.::::..:.::|||||.|||.||:.|:.|:..:.:.|.:
Mouse    25 SADENGNLSSALCSMSP-TTSSQVLARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--- 85

  Fly    90 EGQAKHTKLEKADILELTVRH------------FQRHRNLDDPTVNKYRA-GYTDCAREVARYLA 141
                  .|||||:||::||.|            |..|....|     ||: |:.:|..||||||:
Mouse    86 ------AKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMD-----YRSLGFRECLAEVARYLS 139

  Fly   142 TPE----PPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNHGK 202
            ..|    ..|:           :.||:.||             ::.|:..|:.|.:      ||.
Mouse   140 IIEGLDASDPL-----------RVRLVSHL-------------NNYASQREAASGA------HGG 174

  Fly   203 KSQ-PEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPVTPAPQDENNNRGLQAQAQTPIPIQVQS 266
            ... |...:..:....::|:                   ..||:.:.|.|..|....|
Mouse   175 LGHIPWGSAFGHHPHIAHPL-------------------LLPQNGHGNAGTAASPTEP------- 213

  Fly   267 QTQGQ-TSPHVDAVAPSELSYEEDRNKVCANVLEQYKQQLKAHVQQQPESANGVLVLPPHYVQLA 330
            ..||: .|.|.:|.|                        |:|     |.|.....|||  .|..|
Mouse   214 HHQGRLASAHPEAPA------------------------LRA-----PPSGGLGPVLP--VVTSA 247

  Fly   331 AALGLSAQPLVDPIATRTDFERLIELQRVQP------HLAGKLSPSFPGGLEAAHV 380
            :.|   :.||:..:|:.:.|          |      ||   ||||.|  .:||::
Mouse   248 SKL---SPPLLSSVASLSAF----------PFSFSSFHL---LSPSTP--TQAANL 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	25/80 (31%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	16/51 (31%)
Hey1	NP_034553.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		9/28 (32%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	48..117		24/77 (31%)
		HLH	50..107	CDD:238036	23/65 (35%)
		ORANGE	120..166	CDD:128787	18/74 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..234		15/94 (16%)
		YRPW motif	289..292
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810