DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sidpn and Hes2

DIOPT Version :9

Sequence 1:	NP_523599.1	Gene:	Sidpn / 35168	FlyBaseID:	FBgn0032741	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001288734.1	Gene:	Hes2 / 15206	MGIID:	1098624	Length:	157	Species:	Mus musculus

Alignment Length:	148	Identity:	56/148 - (37%)
Similarity:	73/148 - (49%)	Gaps:	24/148 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KRTNKPLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTVRHFQR-- 113
            ::..|||:|||||||||:||:.||.|:|...       |...::.:|||||||||:|||..|.
Mouse    14 RKNLKPLLEKRRRARINESLSQLKGLVLPLL-------GAETSRSSKLEKADILEMTVRFLQEQP 71

  Fly   114 ---HRNLDDPTVNKYRAGYTDCAREVARYLATPEPPPMGTMPTLAEPGSKARLLRHLDQCIAEID 175
               :.:.....:|.|..||..|...:||.|     |....:    ||...||||.||.|.....|
Mouse    72 ATLYSSAAPGPLNSYLEGYRACLARLARVL-----PACSVL----EPAVSARLLEHLRQRTVSDD 127

  Fly   176 VEICPHSTAAFAESPSSS 193
               .|..|...|.:|:.|
Mouse   128 ---SPSLTLPPAPAPAPS 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	32/70 (46%)
Sidpn	NP_523599.1	Hairy_orange	125..172	CDD:284859	17/46 (37%)
Hes2	NP_001288734.1	bHLH_SF	10..73	CDD:381792	32/65 (49%)
		ORANGE	85..123	CDD:128787	17/46 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		6/22 (27%)
		WRPW motif	154..157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870