DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC12

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001380726.1	Gene:	ABCC12 / 94160	HGNCID:	14640	Length:	1359	Species:	Homo sapiens

Alignment Length:	1385	Identity:	447/1385 - (32%)
Similarity:	720/1385 - (51%)	Gaps:	173/1385 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANEL-ETN 72
            |..||.:.:.:.|..:|.:..|..:||.:..|....|........:::...:....|..|: ...
Human    41 LAPNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVARVG 105

  Fly    73 KKNASLLRVLFRVFGRYFVFLGLV--LFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGG 135
            .:.|||..|::: |.|..|.:.:|  :.|: ::..:.|..|:..|  ......||        |.
Human   106 PEKASLSHVVWK-FQRTRVLMDIVANILCI-IMAAIGPTVLIHQI--LQQTERTS--------GK 158

  Fly   136 VILGSALKVILMN---------PYSFAVTH-LGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHII 190
            |.:|..|.:.|..         ..::|:.: ..::::|.:|::::...:.. || |..||.|.::
Human   159 VWVGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLVSF-KT-LTHISVGEVL 221

  Fly   191 NLISNDLGRMDTFIQFTHYLWLAPLQA----LMVTYLMYQ--EIGIAAVFGMTFILLFIPLQMYL 249
            |::|:     |::..|...|: .||.|    |||....|.  .:|..|:.|::..::|||:||::
Human   222 NILSS-----DSYSLFEAALF-CPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFM 280

  Fly   250 GKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCL 314
            .|..|..|....:.:|||::.|.|.:..|::|||||||..|...:...|.:|...:....:
Human   281 AKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGF---- 341

  Fly   315 IWSFNRFLTP----VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETL 375
            :.|.|..|.|    ::|.|:|...:|:.|.|||.|||.:.|.:||::.:: |.....:...||..
Human   342 VQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFSI-AILPFSIKAMAEAN 405

  Fly   376 VSIKRVQKLLLS---GEVVAKDEN-----VVSNGAEEDLQEAREKLLVTPTPMRAPEKPPH---- 428
            ||::|::|:|:.   ...:.:.|:     :::|.......||..|    .||.:...:..|
Human   406 VSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRK----STPKKLQNQKRHLCKK 466

  Fly   429 NSEDCVSISELKAKWTTNSPDYT------LSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELR 487
            ...:..|.....||..|...:.:      |..::..|..|.::.|.|:.|||||||:.|:||:::
Human   467 QRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQ 531

  Fly   488 VESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTIL 552
            ::.|.:.|.|:::|.||:.|:|.|.||:|||||:..|.:||...||.|.|::|...||..|.|.:
Human   532 LQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596

  Fly   553 GDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQ 617
            |:||.:|||||:.||||||:||.|..:|||||||||||:.|.:.:||||::..||.|.|:|||||
Human   597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQ 661

  Fly   618 LQFLQQADQIVIMEMGKVKAVGTYESLHKS------------GLDF------------------- 651
            ||||:..|:::::|.|::...||::.|.:.            ||.|
Human   662 LQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESP 726

  Fly   652 -------GIVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQL 709
                   ||::..|.|:.:..::....|...|.:                 |.|.|.|..:..|.
Human   727 AEREEDAGIIVLAPGNEKDEGKESETGSEFVDTK-----------------VPEHQLIQTESPQE 774

  Fly   710 GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVA---HNYT---T 768
            |......|..|.:|.||:|.....:..|:...|.|:..:::|..|:.:..:|..   .|.|   .
Human   775 GTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839

  Fly   769 DAKDADFEMHA-AYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNP 832
            .|..||...|. .::|....|..::..:.:.|:|....:.||..||:::|..|.::.|.||:..|
Human   840 GAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTP 904

  Fly   833 AGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP--LFLIPALAFGIVIYYLRS 895
            .|.::|||||||.::|..||......:|.|.:....::::|.|.|  |.::.:||.|..| .||.
Human   905 TGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLVVASLAVGFFI-LLRI 968

  Fly   896 FYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASY---MFI 957
            |: :...::|::|..:|||.::|..:|:.||..|.|:|             ...|..:|   .|.
Human   969 FH-RGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYG-------------KKESCITYHLLYFN 1019

  Fly   958 STSRAFAYWMDI------FCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAE 1016
            ...|.||..||:      |.|..  ::||||.....||.   ||:::..:.|:|.:|..||...|
Human  1020 CALRWFALRMDVLMNILTFTVAL--LVTLSFSSISTSSK---GLSLSYIIQLSGLLQVCVRTGTE 1079

  Fly  1017 LENTMISVERMIEY-EEIEPE--GPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKS 1078
            .:....|||.:.|| ....||  .||:.....|   .||.:|:|.|.:..:||..  .:..||.|
Human  1080 TQAKFTSVELLREYISTCVPECTHPLKVGTCPK---DWPSRGEITFRDYQMRYRD--NTPLVLDS 1139

  Fly  1079 LSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEP 1142
            |:..|:..:.||||||||:|||||..||||| ....|::.||:.|...:.|.|||:|:::|||:|
Human  1140 LNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDP 1204

  Fly  1143 VLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLAR 1207
            |||.||||:|||||:.::|:.||..||...::|.:..:...|:.::||.|.|||||:|||:|:||
Human  1205 VLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVAR 1269

  Fly  1208 AILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVE 1272
            |:||:::|:::|||||::|.:||.|:|.||::.|:.|||||:||||:|:::.|.||||:.|:|:|
Human  1270 ALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIE 1334

  Fly  1273 FGTPYELLTADDTNAFQDLV 1292
            |..| |:|.....:||..|:
Human  1335 FDKP-EVLAEKPDSAFAMLL 1353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	442/1369 (32%)
		ABC_membrane	94..360	CDD:294371	78/287 (27%)
		ABCC_MRP_domain1	434..634	CDD:213217	95/205 (46%)
		ABC_membrane	736..980	CDD:294371	72/261 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	110/221 (50%)
ABCC12	NP_001380726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..491		10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151579
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660