DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_016866934.1	Gene:	ABCC10 / 89845	HGNCID:	52	Length:	1558	Species:	Homo sapiens

Alignment Length:	1385	Identity:	452/1385 - (32%)
Similarity:	691/1385 - (49%)	Gaps:	194/1385 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PENPRERSNIFSALSFWYTIPTFIKGQKVTL-GAKDLYRALKEHRAES--LGNKLCSSWANELET 71
            ||...:..:..|..|:.:..|...:|....| ..:|:.|.  .||.:.  |.....:.|
Human   262 PEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRL--PHRLQPTYLARVFQAHW------ 318

  Fly    72 NKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSF--SNPSPTSNGVAYA--Y 132
             ::.|.|.|.|:..|||.::.||| |..:..:|......|:.|:..|  ....|.|:|:.||  .
Human   319 -QEGARLWRALYGAFGRCYLALGL-LKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGL 381

  Fly   133 AGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDL 197
            |||.:||:    :|.|.|.:.|..:.|:.|..|.:::|.|.|:|..:   ...||..:||:..|.
Human   382 AGGAVLGA----VLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPS---RPPTGEALNLLGTDS 439

  Fly   198 GRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAI 262
            .|:..|....|..|..|||..:..||:||::|:|.|.|:...||.:|:...:..:|.....:...
Human   440 ERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQ 504

  Fly   263 RSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAY--AKCL-IWSFNRFLTP 324
            ..|.|::::||:::||:|||...||......|...|.:|:..:|.:.|  |.|: :|:....:..
Human   505 HKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVIS 569

  Fly   325 VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE 389
            :.||::   :||||..|||...|...|...::...:..:..| :....|..||:.|:|..|
Human   570 IVIFIT---YVLMGHQLTATKVFTALALVRMLILPLNNFPWV-INGLLEAKVSLDRIQLFL---- 626

  Fly   390 VVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHN-----SEDCVSISELKAKW-TTNSP 448
                           ||                   |.||     |.||..:. .:.|| ..:.|
Human   627 ---------------DL-------------------PNHNPQAYYSPDCGRLG-AQIKWLLCSDP 656

  Fly   449 DYTLSGV----------------------NLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESG 491
            ....|.|                      :|:|..|.||.|||..|.|||||:.||.|||....|
Human   657 PAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRG 721

  Fly   492 EIEVTG---SMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILG 553
            .:.|.|   ....|:||||:...|:|.|||||:..|.:.|..|:..|||..|..:||..|:|.:|
Human   722 HVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 786

  Fly   554 DRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQL 618
            ::|.:|||||:|||:|||:||::..:|||||||:|||:.||..|...|:.|.|.....:|.||:.
Human   787 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRT 851

  Fly   619 QFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITDQRRSSVK 683
            ::|::||.:::||.|::...|....:      ..:|...|   ...||:...:.|.|.|.
Human   852 EYLERADAVLLMEAGRLIRAGPPSEI------LPLVQAVP---KAWAENGQESDSATAQS----- 902

  Fly   684 SVLSHAESCPEDVGEEQKIN---LQRQ--QLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGL 743
              :.:.|...|.:.|||..:   ||.:  :.|...|.||..|::|.|..|:.:::.:..: .|..
Human   903 --VQNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLL-MQAT 964

  Fly   744 ASLGDYFLSPWVSR----NEKMVAHNYTTDAK------------------------------DAD 774
            .:..|::||.|:|:    |....|...|:.|.                              .:|
Human   965 RNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSD 1029

  Fly   775 FEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNR 839
            ...:.. :|..|..::.:.|:.|:.||....::|:..||..:...:..|.:.|||..|.|.||||
Human  1030 IRFYLT-VYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNR 1093

  Fly   840 FSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP--LFLIPALAFGIVIYYLRSFYLKTSL 902
            ||.|:...|:.||.|:..::.:.....|.:.|:....|  |.|:|.|:  |:.|:::..|..:|.
Human  1094 FSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLS--IMYYHVQRHYRASSR 1156

  Fly   903 DVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWM 967
            :::||.:.|.||:|||.|.:|.|||.:||.||....|.|.....:::....:...:|.:    |:
Human  1157 ELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQ----WL 1217

  Fly   968 DIFCVLF----------IAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMI 1022
            ||...|.          ||::.....:..|..   |||:::.|:.|||.:...|....:.|..::
Human  1218 DIRLQLMGAAVVSAIAGIALVQHQQGLANPGL---VGLSLSYALSLTGLLSGLVSSFTQTEAMLV 1279

  Fly  1023 SVERMIEYE---EIEPEG-PLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVI 1083
            ||||:.||.   ..||:| ||:...      .|..||.:||.::.|.|.|.|  .:.|..::|.:
Human  1280 SVERLEEYTCDLPQEPQGQPLQLGT------GWLTQGGVEFQDVVLAYRPGL--PNALDGVTFCV 1336

  Fly  1084 KPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSG 1147
            :|.||:|||||||:|||||:..||| |..:.|.|.:|..||:.:.|..|||:::||||||.||||
Human  1337 QPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSG 1401

  Fly  1148 TVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRD 1212
            |||.||||...:.|..||.||::..|.:|:.|:. ||:.::.|||.:.|:|||||:|||||:|.|
Human  1402 TVRENLDPQGLHKDRALWQALKQCHLSEVITSMG-GLDGELGEGGRSLSLGQRQLLCLARALLTD 1465

  Fly  1213 NRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPY 1277
            .:||.:|||||:||.:||.|:|.||..:|...||||:||||:||::||||||:.||||||..:|
Human  1466 AKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP- 1529

  Fly  1278 ELLTADDTNAFQDLVKQTGQ 1297
            ..|.....:.||.|::.:.|
Human  1530 ATLRNQPHSLFQQLLQSSQQ 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	445/1365 (33%)
		ABC_membrane	94..360	CDD:294371	82/272 (30%)
		ABCC_MRP_domain1	434..634	CDD:213217	89/225 (40%)
		ABC_membrane	736..980	CDD:294371	74/289 (26%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	118/221 (53%)
ABCC10	XP_016866934.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650