DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and VMR1

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_011828.1	Gene:	VMR1 / 856350	SGDID:	S000001027	Length:	1592	Species:	Saccharomyces cerevisiae

Alignment Length:	1412	Identity:	439/1412 - (31%)
Similarity:	710/1412 - (50%)	Gaps:	176/1412 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FKNEDLPENPRER-SNIFSALSFWYTIPTFI-KGQKVTLGAKDLYRALKEHRAESLGNKLCSSWA 66
            :..:|.....||. |:|.|.:: |..|..|| :.||.|:..||:                   |.
Yeast   258 YVRDDHTSPSREHISSILSCIT-WSWITNFIWEAQKNTIKLKDI-------------------WG 302

  Fly    67 NELE------------TNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMK-LISSF 118
            ..:|            .||...:|...||..|..| :.:|::...:..|:.:.|..||| .:...
Yeast   303 LSMEDYSIFILKGFTRRNKHINNLTLALFESFKTY-LLIGMLWVLVNSIVNLLPTILMKRFLEIV 366

  Fly   119 SNPSPTSN--GVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLR------ 175
            .||:.:|:  .:|:.|..|:.:......|..:...|....:.|:||..:...||.|.||
Yeast   367 DNPNRSSSCMNLAWLYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTS 431

  Fly   176 -LTKTDLGEIST--GHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMT 237
             .|.:|...||.  |.||||||.|..::.....:.:....|.:..::|..|::..:|::|..|::
Yeast   432 PKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGIS 496

  Fly   238 FILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEI 302
            .||:..||...|...:...:.:|...:|:|:..:.|.:..|:::|.:|||......:...|.||:
Yeast   497 IILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKEL 561

  Fly   303 NSIRHVAYAKCLIWSFNRFL---TP---VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRT--- 358
            .|:    ..|.|:||...||   ||   ..:..::..|| ....|.|.:||...:.:.:::|
Yeast   562 RSL----LKKSLVWSVTSFLWFVTPTLVTGVTFAICTFV-QHEDLNAPLAFTTLSLFTLLKTPLD 621

  Fly   359 ---NMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPM 420
               ||.::.:       ::.||:||:...|                 ..|..|...:|.::|
Yeast   622 QLSNMLSFIN-------QSKVSLKRISDFL-----------------RMDDTEKYNQLTISP--- 659

  Fly   421 RAPEKPPHNSEDCVSISELKAKWTTNSPD---YTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAI 482
                     .::.:........|..|..|   :.|.|:|::...|.|..|:|.||||||:|:..:
Yeast   660 ---------DKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGL 715

  Fly   483 LGELRVESGEIEV----------------TGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLV 531
            ||||.:.||.|.|                |.|.:|.||..||.:.||:.||:|....:..||:.|
Yeast   716 LGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKV 780

  Fly   532 VRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARR 596
            :..|.|:||.|:||..|.|.:|::|.:||||||.||||||:||..|...||||.||||||..|..
Yeast   781 IDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVW 845

  Fly   597 LFEECLRGHL-RDKIVILVTHQLQF-LQQADQIVIMEMGKVKAVGTYESLHKSGL--DFGIVLDD 657
            ::|.|:.|.| :::..|||||.:.. |:.|...:::|.||||..||...|...||  :..:.|..
Yeast   846 IYENCITGPLMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLFKEKYVQLSS 910

  Fly   658 PVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFR 722
            ..:.||...:|.:.....|.::  ::.|..:.......|.:.|.|..:.:..|.....||..|.:
Yeast   911 RDSINEKNANRLKAPRKNDSQK--IEPVTENINFDANFVNDGQLIEEEEKSNGAISPDVYKWYLK 973

  Fly   723 AGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVS-RNEKMVAHNYTTDA------KDADFEMHAA 780
            ..|||.:.:.:...::.:|.|.....:::..||: .|.::.|..:..|.      .|:....|.|
Yeast   974 FFGGFKALTALFALYITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKNKHNA 1038

  Fly   781 Y----IYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFS 841
            :    :|.||.::..|:...::.:.|...||||.::.|::...:..|.:.||:..|.|.|:||||
Yeast  1039 FYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFS 1103

  Fly   842 KDMGQVD-EMLPTIIMTVIQDFLLF--GGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLD 903
            ||:..|| |::|.:.:|:   |.|.  ...|.:|.::.|.||..|:...::.:::..:||..|.:
Yeast  1104 KDIEGVDQELIPYLEVTI---FCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRE 1165

  Fly   904 VKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMD 968
            :|||::.|:||::.||:.:|.|:.||||||.......|.....|.::.|.:....|.:.|::.:|
Yeast  1166 LKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVD 1230

  Fly   969 IFCVLFIAMITLSFFIFPPSSAADV-----GLAITQAMGLTGTVQWTVRQSAELENTMISVERMI 1028
            :... ||.:.:.||.:.   :.|::     |:::|.|:..|....|.||..:..|..|.||||:.
Yeast  1231 MIGA-FIVLASGSFILL---NIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLK 1291

  Fly  1029 EYEEIEPEGPL---EATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVG 1090
            ||..||.|..|   |.........|||:.|:||...|||||.|.|  ..|::::||.:.|:.|:|
Yeast  1292 EYSSIEQENYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNL--PPVIRNVSFKVDPQSKIG 1354

  Fly  1091 IVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLD 1154
            ||||||||||::|.|||| |....|.::||.:|.:.:.|..||..|:||||:|:||:||::.|:|
Yeast  1355 IVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVD 1419

  Fly  1155 PFDEYSDDRLWCALEEV------ELKDVVASVA---------TGLETKITEGGSNFSVGQRQLVC 1204
            |:|||.:.:::.||.:|      |.::|:.|..         ..|.|:|.|||.|.|.|:|||:.
Yeast  1420 PYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLF 1484

  Fly  1205 LARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGR 1269
            :||::||:.:|:::||||:::|..:|.|||..||::|.:.|:||:||||.:::|.||::|||||.
Yeast  1485 IARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGE 1549

  Fly  1270 VVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEK 1316
            |.|:..|.||| .|:...|..:.:.:|..   .|||...::..|..|
Yeast  1550 VKEYDRPSELL-KDERGIFYSMCRDSGGL---ELLKQIAKQSSKMMK 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	429/1367 (31%)
		ABC_membrane	94..360	CDD:294371	73/289 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	89/220 (40%)
		ABC_membrane	736..980	CDD:294371	72/257 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	107/236 (45%)
VMR1	NP_011828.1	MRP_assoc_pro	212..1575	CDD:188098	433/1390 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640