DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and STE6

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_012713.1	Gene:	STE6 / 853671	SGDID:	S000001692	Length:	1290	Species:	Saccharomyces cerevisiae

Alignment Length:	1372	Identity:	305/1372 - (22%)
Similarity:	547/1372 - (39%)	Gaps:	306/1372 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 MNPYSFAVT-HLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYL 210
            ||..||..| |..:...|.:.: .||..:.:.   :|.::||.:..:.|...||:  |...:.::
Yeast     1 MNFLSFKTTKHYHIFRYVNIRN-DYRLLMIMI---IGTVATGLVPAITSILTGRV--FDLLSVFV 59

  Fly   211 WLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQ--MYLGKKISGLRLKTAI----------- 262
            .....|.| .:.|:.:.:.:.|:...:..::::.|.  |::|:: .|.|:::.|
Yeast    60 ANGSHQGL-YSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGER-QGFRIRSQILEAYLEEKPME 122

  Fly   263 ---RSDKRMRIMTEIIAGIQVIK-------------------------MYAWELP---------- 289
               .::|.:...|:|...::.::                         .|:|.|.
Yeast   123 WYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPII 187

  Fly   290 ------FEKMVAHARHKEINSIRHVAYAKCLIWSFNR--------------------FLTPVSIF 328
                  |.:|: |...::.||....| |:.|.||.|.                    .|...:.|
Yeast   188 TFFAVVFSRMI-HVYSEKENSETSKA-AQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFF 250

  Fly   329 LSLVGFVLMG----RFLTAEVAFLITAYY-------------NVVRTNMTAYFSVGVTQTAETLV 376
            :....||...    ||||  :...:..::             |.|.|...:...:|.|.. .||.
Yeast   251 IKSCFFVAANAGILRFLT--LTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLGSTLN-NTLH 312

  Fly   377 SIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMR---APEKPPHNSEDCVSISE 438
            .|..:||   .|..:.|...::.:|::.:             |:.   |.:.|...:...::.:.
Yeast   313 QIVVLQK---GGVAMEKIMTLLKDGSKRN-------------PLNKTVAHQFPLDYATSDLTFAN 361

  Fly   439 LKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTG------ 497
            :...:.:...:..|..|:|...||....|||.:|||||:|...:|......:|.|.:.|
Yeast   362 VSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTI 426

  Fly   498 -------SMSYASQEPWLFSGTVRQNILFGQPMDRRRYD--------LVVRKCALE-RDFELLPL 546
                   :::...|...||:.|:|:|||.|.....|..|        |:...|.:. .|..:|.|
Yeast   427 DQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDL 491

  Fly   547 KD--KTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDK 609
            .|  :|::|..|.:|||||:.|:::||:..||..|..||:.:||:| .|.|.|..:.:|...:.|
Yeast   492 PDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALD-IVHRNLLMKAIRHWRKGK 555

  Fly   610 IVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPVN--------DNEAAE 666
            ..|::||:|..::..|.:.:|:.|:|...||...|          |.||..        .|:.::
Yeast   556 TTIILTHELSQIESDDYLYLMKEGEVVESGTQSEL----------LADPTTTFSTWYHLQNDYSD 610

  Fly   667 DRSRTSSITDQRR-SSVKSVLSHAE-----SCPEDVGEEQ---------------KINLQRQQLG 710
            .::...:.|:::. .:|:|..|..|     ||..::|.::               .:..:|.::.
Yeast   611 AKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVE 675

  Fly   711 RNGLGVYVDYFR-----AGGGFLSF--------------SVVMTFFVCSQGLASLGDYFLSPWVS 756
            ...:|..:...:     .|...||.              .:::...:||....:....|...:..
Yeast   676 EENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSF 740

  Fly   757 RNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSI--MVTIKRSFLFFNLAMRASIQLHNSMFRG 819
            ..|.:|.   :||.|.......|.:..:::.|.:.  :....:.||....:....:.|.|.:...
Yeast   741 LLEGIVP---STDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEK 802

  Fly   820 ISRASMYFFN--KNPAGSI----LNRFSKDMGQVDEMLP--TIIMTVIQDFLLF----GGNIIVI 872
            ::|.:|.:|:  .|.|..|    ||........|.|.|.  |..:||....|::    |..:.::
Yeast   803 LTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLV 867

  Fly   873 AI-VNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGS 936
            .| :.||.:|.:..:|.::.       |...|.|...|...:.:|.    .:..:.||:.
Yeast   868 CISMFPLIIIFSAIYGGILQ-------KCETDYKTSVAQLENCLYQ----IVTNIKTIKC----- 916

  Fly   937 ILEAEFD---GYQD----MHSSASYMFISTSRAFAYW-MDIFCV--------LFIAMI------- 978
             |:|||.   .|.|    |...||...|:|....:.. |.:.|:        |.:.||
Yeast   917 -LQAEFHFQLTYHDLKIKMQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKE 980

  Fly   979 ---TLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPE---- 1036
               |.:..:|...|...:...|...........|..|...|..||:          |:|..
Yeast   981 MFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTL----------EVENNNART 1035

  Fly  1037 ----GPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGA 1097
                |......:|||        .:....|:..| |...:..|.|:::|.:...:.:||:|.:|.
Yeast  1036 VGIAGHTYHGKEKKP--------IVSIQNLTFAY-PSAPTAFVYKNMNFDMFCGQTLGIIGESGT 1091

  Fly  1098 GKSSLINALFRLSYN--DGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNL--DPFDE 1158
            |||:|:..|.:| ||  .|.::||..|.||..|..||.:||::.|:|:||:||:|.||  ...||
Yeast  1092 GKSTLVLLLTKL-YNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDE 1155

  Fly  1159 YSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATA 1223
            ..:..::.||:.|.:.|.|.|...||:|:|..  :..|.||.|.:|:|||:||.::||::||.|:
Yeast  1156 ILEIEMYDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQRLCIARALLRKSKILILDECTS 1218

  Fly  1224 NVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAF 1288
            .:|..:.::|...::........:.:.|....:...:.:.|:..|:|||.|. ::.|..:....|
Yeast  1219 ALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGN-FDTLYNNRGELF 1282

  Fly  1289 QDLVKQT 1295
            |.:..|:
Yeast  1283 QIVSNQS 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	301/1356 (22%)
		ABC_membrane	94..360	CDD:294371	54/307 (18%)
		ABCC_MRP_domain1	434..634	CDD:213217	65/223 (29%)
		ABC_membrane	736..980	CDD:294371	58/284 (20%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	74/224 (33%)
STE6	NP_012713.1	MdlB	24..605	CDD:224055	133/619 (21%)
STE6	NP_012713.1	MdlB	702..1289	CDD:224055	150/629 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100