DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC11

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001357425.1	Gene:	ABCC11 / 85320	HGNCID:	14639	Length:	1384	Species:	Homo sapiens

Alignment Length:	1345	Identity:	427/1345 - (31%)
Similarity:	691/1345 - (51%)	Gaps:	118/1345 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLG-NKLCSSWANELETNK-KN 75
            |.:.:.:||.|:..:..|..|:..:..|. ::....|..|.|.... .:|...|..|:.... :.
Human    85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLD-ENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEK 148

  Fly    76 ASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNP--SPTSNGVAYAYAGGVIL 138
            ||:|.|:.|......:|..|:..|..:...:.|:.::..|..:|..  ....:||...:|  :.|
Human   149 ASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFA--LFL 211

  Fly   139 GSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTF 203
            ...:|.:..:..........::.|..|||..:.|.::.  ..:..|::|..|:..:.|:..:...
Human   212 SECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQF--KSVIHITSGEAISFFTGDVNYLFEG 274

  Fly   204 IQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRM 268
            :.:...:.:.....::.:...|..||..|...:...||..||.:::.:.....:..|:..||:|:
Human   275 VCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRI 339

  Fly   269 RIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKC-LIWSFNRFLTPVSIFL--- 329
            |:.:|::..|::||||.||.||.|::...|.||...:.     || |:.|    ||.:::|:
Human   340 RVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLE-----KCGLVQS----LTSITLFIIPT 395

  Fly   330 -SLVGFVLMGRF----LTAEVAFLITAYYNVVRTNMTAYF----SVGVTQTAETLVSIKR----- 380
             :...:||:...    |||.:||.:.|..|::|  ::.:|    ..|:|.:...::..|:
Human   396 VATAVWVLIHTSLKLKLTASMAFSMLASLNLLR--LSVFFVPIAVKGLTNSKSAVMRFKKFFLQE 458

  Fly   381 -----VQKLLLSGEVVAKDENVVS---------NGAEEDLQEAREKLLVTPTPMRAPEKPPHNSE 431
                 ||.|....:.:..:|..:|         |||.|                  .|:..|.||
Human   459 SPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALE------------------LERNGHASE 505

  Fly   432 ------DCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVES 490
                  |.:...|     ..||....|..:||.|..|.::.:.|:||||||||:.|||.|:.:..
Human   506 GMTRPRDALGPEE-----EGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLE 565

  Fly   491 GEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDR 555
            |.:.|.||::|..|:.|:.||.:|:|||.|...|:.||..|:..|:|.||.||||..|.|.:|:|
Human   566 GSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGER 630

  Fly   556 GASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQF 620
            |.:||||||.||||||:||.|..||||||||||||:.|.:.:||||::..||.|.|:|||||||:
Human   631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQY 695

  Fly   621 LQQADQIVIMEMGKVKAVGTY-ESLHKSGLDFGIVLDDPVNDNEAAEDRSR-TSSITDQRRSSVK 683
            |:...||:::|.||:...||: |.:.|.|....::   .....||..|..: |:.|.::.:...:
Human   696 LEFCGQIILLENGKICENGTHSELMQKKGKYAQLI---QKMHKEATSDMLQDTAKIAEKPKVESQ 757

  Fly   684 SVLSHAESC----PEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLA 744
            ::.:..|..    ..:|.|.|....:..:.|.....||..|.:|.||::...::..|.|....|.
Human   758 ALATSLEESLNGNAGNVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 822

  Fly   745 SLGDYFLSPWVSR----NEKMVAHNYTTDAKD-ADFEMHAAY--IYMLITVLSIMVTIKRSFLFF 802
            ....::||.|:.:    |....::....|..: ||....:.|  :|.|..:|.|.|.:..|.:|.
Human   823 IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFT 887

  Fly   803 NLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGG 867
            .:..:||..|||.:|..:.|..|.||:..|.|.:||.|:.|:.|:|::||......:...|:...
Human   888 KVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIA 952

  Fly   868 NIIVIAIVNPLFLIPALAFGIV--IYYLRSFYLKTSLDV-KRLEASTRSPVYSHFAASLNGLSTI 929
            .::::::::|..|:......::  |||:   ..|.::.| ||||..:|||::||...||.|||:|
Human   953 VLLIVSVLSPYILLMGAIIMVICFIYYM---MFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSI 1014

  Fly   930 RAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVG 994
            ..:|......::|....|..::...:|:|::|    ||.:...:...::||:..:|.....:...
Human  1015 HVYGKTEDFISQFKRLTDAQNNYLLLFLSSTR----WMALRLEIMTNLVTLAVALFVAFGISSTP 1075

  Fly   995 -----LAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEI-EPEGPLEATADKKPHESWPE 1053
                 :|:...:.|..:.|.|.|...|.|....:|||:::|.:: ..|.||.......| :.||:
Human  1076 YSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCP-QGWPQ 1139

  Fly  1054 QGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVR 1117
            .|:|.|.:..::|..  .:.:||..::..|:..|.||||||||:|||||..||||| ....|.:.
Human  1140 HGEIIFQDYHMKYRD--NTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRIL 1202

  Fly  1118 IDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVAT 1182
            ||..|...:||.|||||:|:|||:|||.|||:|.||||||.::|.::|.|||...|...::....
Human  1203 IDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPK 1267

  Fly  1183 GLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVL 1247
            .|.|.:.|.|.|||||:|||:|:|||:||:::|:::|||||::|.:||.|||.|||..|:.||||
Human  1268 KLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVL 1332

  Fly  1248 TVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLV 1292
            .:|||:.|:::.|.:|||..|:||||..| |:|.....:.|..|:
Human  1333 VIAHRVTTVLNCDHILVMGNGKVVEFDRP-EVLRKKPGSLFAALM 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	424/1332 (32%)
		ABC_membrane	94..360	CDD:294371	63/276 (23%)
		ABCC_MRP_domain1	434..634	CDD:213217	99/199 (50%)
		ABC_membrane	736..980	CDD:294371	69/253 (27%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/221 (50%)
ABCC11	NP_001357425.1	PLN03130	85..1373	CDD:215595	425/1340 (32%)
ABCC11	NP_001357425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..523		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650