Protein Alignment CG31792 and YOR1

DIOPT Version :9

• Sequence 1: NP_001260548.1
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_011797.3
• Gene: YOR1 / 853198
• SGDID: S000003513
• Length: 1477
• Species: Saccharomyces cerevisiae
• Alignment Length: 1473
• Identity: 431/1473 - (29%)
• Similarity: 693/1473 - (47%)
• Gaps: 249/1473 - (16%)

  Fly     1 MQSFKNEDLPENPRER-------SNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLG 58
            :.|.|..::|:...||       :||.|.:.||:.:|....|.|.|:...||::.......|:|.
Yeast    90 LHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLY 154

  Fly    59 NKLCSSWANELETNKK----------------NASL-----LRVLFRVFGRYFVFLGLVLFCLEV 102
            :....:.....|..:|                ||.|     ||.|...|.:.: |:.:|...|..
Yeast   155 DDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQY-FMSIVFAILAN 218

  Fly   103 ILT-VQPMFLMKLI-----SSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHL---- 157
            ..: ..||...:||     .:..:....:.|:.||      :|:.| ::.:|..:|  .|.
Yeast   219 CTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYA------IGACL-MMFVNGLTF--NHFFHTS 274

  Fly   158 ---GLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAP-LQAL 218
               |::.:..::....:|....:.........|.:.:.::.||.|::..:.|..:|...| :.|:
Yeast   275 QLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAI 339

  Fly   219 MVTYLMYQ-----EIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGI 278
            .:..|:..     .:||...||..||.||      ..|.|.|.|:...|.:|.|:.:|.|::..|
Yeast   340 CIVLLIVNLGPIALVGIGIFFGGFFISLF------AFKLILGFRIAANIFTDARVTMMREVLNNI 398

  Fly   279 QVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFL----SLVGFVLM-- 337
            ::||.|.||..:||.:...|.|||:.:|.:..::       .||..:::.|    |||.|:.|
Yeast   399 KMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSR-------NFLIAMAMSLPSIASLVTFLAMYK 456

  Fly   338 ----GRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVV 398
                ||  .....|...:.:.|:...| .:..:.:....:.::.:.|:|.||
Yeast   457 VNKGGR--QPGNIFASLSLFQVLSLQM-FFLPIAIGTGIDMIIGLGRLQSLL------------- 505

  Fly   399 SNGAEEDLQEAREKLLVTPTPMRAPE---KPPHNS--------EDCVSISELKAK---------- 442
              .|.||  :..:.:.:.|:|...|:   |..|.|        .|.:..::.:||
Yeast   506 --EAPED--DPNQMIEMKPSPGFDPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKR 566

  Fly   443 ---W-----TTNSP---DYTL-----------------SGVNLQVHAGALVAIVGHTGSGKSSLI 479
               |     :||..   |..|                 ..:|..:..|..:.|.|..|:|||||:
Yeast   567 KDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLL 631

  Fly   480 QAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELL 544
            .|:.|.:|...|::||.|.:..... ||:.:.:||.||:||.|.::.:||.|||.|:|:.|.::|
Yeast   632 NAMAGSMRKTDGKVEVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDIL 695

  Fly   545 PLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDK 609
            |..|.|.:|:||.:|||||||||:||||||:...|||.||.||||||.|.:.:.:|||.|.|.:|
Yeast   696 PAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANK 760

  Fly   610 IVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSG------LDFGIVLDDPVNDNEAAEDR 668
            ..||.||||..:::|.:::::.......:||.:.|....      |.|.       :.|...||.
Yeast   761 TRILATHQLSLIERASRVIVLGTDGQVDIGTVDELKARNQTLINLLQFS-------SQNSEKEDE 818

  Fly   669 SRTSSITDQ-----RRSSVKSV---------LSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVD 719
            .:.:.:..:     ..|.||.:         :|...:..:.|.:....:.:.:.:....|.:|.:
Yeast   819 EQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYRE 883

  Fly   720 YFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYM 784
            |.:|..|...|..:..:.:...| .:....|.|.|:|         |.|:.|   |:......||
Yeast   884 YIKAAVGKWGFIALPLYAILVVG-TTFCSLFSSVWLS---------YWTENK---FKNRPPSFYM 935

  Fly   785 LITVLSIMVTIKRSFLFFN--------LAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFS 841
            .:....:..    :|:|.|        :.:.||..|:....:.|....|.:.:..|.|.|||||:
Yeast   936 GLYSFFVFA----AFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFT 996

  Fly   842 KDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYL-RSFYLKTSLDVK 905
            ||...:|..|...:..:...|....|..::..:..|.|.| |:.|.:||:.| ...|..:..::|
Yeast   997 KDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAI-AIPFLLVIFVLIADHYQSSGREIK 1060

  Fly   906 RLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIF 970
            ||||..||.||::....|.|:.||:|:.:.....|:.|...:..:.|.|:.:...|....::|:.
Yeast  1061 RLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMV 1125

  Fly   971 CVLFIAMITL-----SFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEY 1030
            .:.|..:|||     :|    |.|||.||:.:|..:.|.|.:...:|...:.||.|.|.||::.|
Yeast  1126 AIAFALIITLLCVTRAF----PISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTY 1186

  Fly  1031 EEIEPEGPLEATADK---KPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIV 1092
               ..|.||||:..|   .|.||||..|:|.|..:...|.|.|  ..|||:|:..||..||:||.
Yeast  1187 ---ATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGL--PIVLKNLNLNIKSGEKIGIC 1246

  Fly  1093 GRTGAGKSSLINALFRLS-YNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPF 1156
            ||||||||::::||:||: ...|.:.||:.|.:.:||.|||.|::||||:||||.||:|.|||||
Yeast  1247 GRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPF 1311

  Fly  1157 DEYSDDRLWCA-----------LEEVELKDVVASVATG------LETKITEGGSNFSVGQRQLVC 1204
            :|.:||.||.|           |.||:|:....:...|      |:..:.|.|||||:|:|||:.
Yeast  1312 NERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLA 1376

  Fly  1205 LARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGR 1269
            |.||::|.::||::||||::||.:||..||..|..:|.:||:|.:||||.||::.||:||::.|.
Yeast  1377 LTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGE 1441

  Fly  1270 VVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFE 1312
            |.||.||:.|.:.:| :.|:.:..::|         |.:.:||
Yeast  1442 VAEFDTPWTLFSQED-SIFRSMCSRSG---------IVENDFE 1474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	422/1429 (30%)
		ABC_membrane	94..360	CDD:294371	67/294 (23%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/237 (37%)
		ABC_membrane	736..980	CDD:294371	63/252 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/238 (47%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	428/1463 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I2258
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.660