Protein Alignment CG31792 and YBT1

DIOPT Version :9

• Sequence 1: NP_001260548.1
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_013052.1
• Gene: YBT1 / 850678
• SGDID: S000003971
• Length: 1661
• Species: Saccharomyces cerevisiae
• Alignment Length: 1427
• Identity: 434/1427 - (30%)
• Similarity: 718/1427 - (50%)
• Gaps: 207/1427 - (14%)

  Fly    26 WYTIPTFI-KGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNASLLRVLFRVFGRY 89
            |..:.:|: |..||::..||::..:.:..:..:..|.  .:..:.:..:|....|. ||..|..|
Yeast   292 WAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKF--RYFVDHKVKRKRIFSLN-LFFFFSNY 353

  Fly    90 FV------FLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMN 148
            .|      |||.||..:..:|      |.:::....:.|...:.:|:.|...:.:|..|..|...
Yeast   354 LVLQCFWAFLGSVLSFIPTVL------LKRILEYVEDQSSAPSNLAWFYVTVMFVGRILVAICQA 412

  Fly   149 PYSFAVTHLGLKIRVGVSSMIYRKCLR----LTKT-----DLGEI----------------STGH 188
            ...|....:.::::..:.|.||.|.||    ..||     |..||                :.|.
Yeast   413 QALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGA 477

  Fly   189 IINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKI 253
            ||||::.|..::.....:.|....|.:..::...|:|:.:|.||:.|:..|:..:||...|.|.|
Yeast   478 IINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYI 542

  Fly   254 SGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRH----VAYAKCL 314
            ..|:.|....:|.|::.:.|....|::||.::||..||        |:||:||.    :...:.:
Yeast   543 GDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFE--------KDINTIRENELSLLLMRSI 599

  Fly   315 IWSFNRFL---TPVSIFLSLVGFVL--MGRFLTAEVAFLITAYYNVVR------TNMTAYFSVGV 368
            :||.:.||   ||..:..:...:.:  .|..||..|||...:.:.::|      ::|.::
Yeast   600 VWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLRDPLDRLSDMLSF----- 659

  Fly   369 TQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDC 433
              ..::.||:.|||..|                 .|:..:..::|.:.|...|
Yeast   660 --VVQSKVSLDRVQDFL-----------------NENDTKKYDQLTIDPNGNR------------ 693

  Fly   434 VSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEV--- 495
            .:.......|..::.|:.|..:|::...|.|..::|.|||||:||:.|:|||:.:.:|::.|
Yeast   694 FAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPAL 758

  Fly   496 -------------TGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLK 547
                         |.|::|.||..||.:.||:.||||..|.:..||..||..|.|:||||:|...
Yeast   759 EPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAG 823

  Fly   548 DKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHL-RDKIV 611
            |.|.:|::|.:||||||.|:||||::|.:|...||||.||||||..|..:::.|:.|.| .|:..
Yeast   824 DLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTC 888

  Fly   612 ILVTHQLQF-LQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPV-----------NDNEA 664
            |||:|.:.. |:.|:.:|::|.|:||..|....:.:.|| ||   :|.:           :.|.|
Yeast   889 ILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGL-FG---EDELVKSSILSRANSSANLA 949

  Fly   665 AEDRSRTSSI--TDQRRSSVKSVLSHAESC---------PEDVGEEQKINLQRQQLGRNGLGVYV 718
            |:..:..|::  ..:::.||.:..||.|:.         .|...:.:.|..:.::.|..||.||.
Yeast   950 AKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYK 1014

  Fly   719 DYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRN----------------EKMVAH--- 764
            .|.:..||:...|.:.:.|:.:|.|.....:::..|.|.|                .|..:|
Yeast  1015 WYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLID 1079

  Fly   765 ----------NYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRG 819
                      :...........|:...:|::|.....::...::.|.|...:.||.::.|.:...
Yeast  1080 WRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNK 1144

  Fly   820 ISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPAL 884
            :..:.:.||:..|.|.|:||||||:..:|:.|...|.......:.....:|:|..:.|.||..|:
Yeast  1145 VLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAI 1209

  Fly   885 AFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFG-AGSILEAEFDGYQDM 948
            ...|:.|::..||:..|.::||.|:.:|||:|.||:.:|.|::|||||| .|..::.......:.
Yeast  1210 VVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDEN 1274

  Fly   949 HSSASYMFISTSRAFAYWMDIF--CVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTV 1011
            :....|:::: :|..|:.:|:.  .|:|.|.:.:.|.|....|.. .|:::|.|:..|....|.|
Yeast  1275 NKPFFYLWVA-NRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGM-AGISLTYAISFTEGALWLV 1337

  Fly  1012 RQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVL 1076
            |..:|:|..|.||||:.||.|||.| |.....:..|.: ||:.||||..:|||||.|.|  ..|:
Yeast  1338 RLYSEVEMNMNSVERVKEYMEIEQE-PYNEHKEIPPPQ-WPQDGKIEVNDLSLRYAPNL--PRVI 1398

  Fly  1077 KSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQ 1140
            |::||.:..:.|:|||||||||||::|.|||| |....|.::||:.|.:.:.|..||..|:||||
Yeast  1399 KNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQ 1463

  Fly  1141 EPVLFSGTVRHNLDPFDEYSDDRLWCALEEVEL--KDVVASVAT-------------------GL 1184
            :|.|||||::.||||:||:||.:::.||:.|.|  ::.:...||                   .|
Yeast  1464 DPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDL 1528

  Fly  1185 ETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTV 1249
            .::|:|||||.|.|||||:||||::||..:|:::|||||::|..:||.||.|||.:|:..|:||:
Yeast  1529 SSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTI 1593

  Fly  1250 AHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREF 1311
            ||||.:::|.|::||||||.|.|:..||.|| .:..:||..:.:.:|:  .|.|::::::.|
Yeast  1594 AHRLRSVIDYDKILVMDAGEVKEYDHPYSLL-LNKQSAFYSMCEHSGE--LDILIELAKKAF 1652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	427/1395 (31%)
		ABC_membrane	94..360	CDD:294371	73/305 (24%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/217 (39%)
		ABC_membrane	736..980	CDD:294371	66/275 (24%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	116/242 (48%)
YBT1	NP_013052.1	MRP_assoc_pro	<353..1639	CDD:188098	417/1346 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.640