Protein Alignment CG31792 and BPT1

DIOPT Version :9

• Sequence 1: NP_001260548.1
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_013086.1
• Gene: BPT1 / 850645
• SGDID: S000003938
• Length: 1559
• Species: Saccharomyces cerevisiae
• Alignment Length: 1403
• Identity: 463/1403 - (33%)
• Similarity: 724/1403 - (51%)
• Gaps: 193/1403 - (13%)

  Fly    26 WY------TIPTFIKGQKVTLGAKDLYRALK------------EHRAESLGNKLCSSWANELETN 72
            ||      :..|||...|:.:   :.||..|            :...:|:..:..::|  |||..
Yeast   215 WYPPVHVLSYITFIWMNKLIV---ETYRNKKIKDPNQLPLPPVDLNIKSISKEFKANW--ELEKW 274

  Fly    73 KKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPS-----PTSNGVAYAY 132
            ....||.|.:::.|||......|.....:::..|||.||...|... ||.     |..|||..|.
Yeast   275 LNRNSLWRAIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGL-NPETSSKYPPLNGVFIAL 338

  Fly   133 AGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDL 197
            ...||  |.:.|.|.|.:...:...||.||..::|::|:|.||||..:..|.|||.|:||:|.|:
Yeast   339 TLFVI--SVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDV 401

  Fly   198 GRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAI 262
            .|:..|.:....:..||:|.::|...:|..:|.|.:.|:..:.:.:|:..:|.:|:..|. ||.:
Yeast   402 LRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLS-KTQM 465

  Fly   263 R-SDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARH-KEINSIRHVAYAKCLIWSFNRFLTPV 325
            : .|.|::.:||::..|:.||:||||.|....:.|.|: .|:.:.|.:.....||: |.....|:
Yeast   466 KYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIY-FAWNCVPL 529

  Fly   326 SIFLSLVGFVLMGRF----LTAEVAFLITAYYNVVRTNMTAYFSVG--VTQTAETLVSIKRVQKL 384
            .:..|..|  |...|    |:..:.|...:.:|::.   :|.:||.  :....||.||::|::..
Yeast   530 MVTCSTFG--LFSLFSDSPLSPAIVFPSLSLFNILN---SAIYSVPSMINTIIETSVSMERLKSF 589

  Fly   385 LLSGEVVAKDENVVSN---GAEEDLQEAREKLLVT--------PTPMRAPEKPPHNSEDCVSISE 438
            |||.|:   |::.:..   .|:|....|.|...:|        .|..::.:....:.|..:..|:
Yeast   590 LLSDEI---DDSFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQ 651

  Fly   439 LKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGE--------IEV 495
            :..|    :.|:      .:...|.||.:||..|:|||:.::||||:|...||.        |..
Yeast   652 IALK----NIDH------FEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIR 706

  Fly   496 TGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLS 560
            :.|::|.|||.|:.:.:||:|||||...|:..|||.::.|.|..|.::||..|:|::|::|.|||
Yeast   707 SSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLS 771

  Fly   561 GGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGH---LRDKIVILVTHQLQFLQ 622
            ||||||:||||:||..|.||||||.|||||:.|::.:.|..|.|.   |::|.:||.|:.:..|:
Yeast   772 GGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILK 836

  Fly   623 QADQIVIMEMGKVKAVGTYE----------SLHKSGLDFGIVLDDPV-NDNEA-AEDRSRTSSIT 675
            .:..|..:|.|::...|.||          .|.|...:|    |.|: |.||: .:...|:.|..
Yeast   837 HSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEF----DSPIDNGNESDVQTEHRSESEV 897

  Fly   676 DQRRSSVKSVLSHAESCPEDVGEEQ----KINLQRQQL--------------------------- 709
            |:   .::..::.:|:..|.|.|.:    |.|.:|..|
Yeast   898 DE---PLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTE 959

  Fly   710 -GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDA 773
             ||....:|:.|.:| .|.|...:...|.:.::......:::|..|...|||        :..:.
Yeast   960 VGRVKTKIYLAYIKA-CGVLGVVLFFLFMILTRVFDLAENFWLKYWSESNEK--------NGSNE 1015

  Fly   774 DFEMHAAYIYMLITVLSIMVTIKRS-FLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSIL 837
            ...|... :|.||.|.|......|| .:....::|.|.:||.||.:.:.|:.|.||...|.|.|:
Yeast  1016 RVWMFVG-VYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRII 1079

  Fly   838 NRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIY-YLRSFYLKTS 901
            ||||.||..||..|..|.....:..|.:...:|::....|.||:..: |.:||| |.::||:..|
Yeast  1080 NRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNM-FLVVIYIYYQTFYIVLS 1143

  Fly   902 LDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFD-----GYQDMHSSASYM--FIST 959
            .::|||.:.:.||:.|..:.||||.|.|.|:.       .|:     .|:.:..:..::  |.||
Yeast  1144 RELKRLISISYSPIMSLMSESLNGYSIIDAYD-------HFERFIYLNYEKIQYNVDFVFNFRST 1201

  Fly   960 SRAFAYWMDIFCVLFIAMITLSFFIFPPS--------SAADVGLAITQAMGLTGTVQWTVRQSAE 1016
            :|    |:.:......|.|.|:..|...:        |:..|||.::.::.:||::.|.||.:..
Yeast  1202 NR----WLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVT 1262

  Fly  1017 LENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSF 1081
            :|..::||||::||.|:.||.. ....:|:|.|:||.:|.|||...|.:|...|  :.||.:::.
Yeast  1263 IETNIVSVERIVEYCELPPEAQ-SINPEKRPDENWPSKGGIEFKNYSTKYRENL--DPVLNNINV 1324

  Fly  1082 VIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLF 1145
            .|:|.||||||||||||||:|..|||| |...:|.:.||..|.:|:||.||||.::||||:...|
Yeast  1325 KIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAF 1389

  Fly  1146 SGTVRHNLDPFDEYSDDRLWCALEEVELK----DVVASVATG-------------LETKITEGGS 1193
            .|||:.|||||:.||:|.|..|:|:..||    .::.|...|             |:.||.|.||
Yeast  1390 EGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGS 1454

  Fly  1194 NFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMD 1258
            |.|||||||:|||||:|..::|||:|||||:||.:||.:||.|||.:|::.|:||:|||:.|::|
Yeast  1455 NLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLD 1519

  Fly  1259 SDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTG 1296
            ||:::|:|.|.|.||.:|.:|| :|.|:.|..|.::.|
Yeast  1520 SDKIIVLDQGSVREFDSPSKLL-SDKTSIFYSLCEKGG 1556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	457/1386 (33%)
		ABC_membrane	94..360	CDD:294371	83/276 (30%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/210 (40%)
		ABC_membrane	736..980	CDD:294371	72/252 (29%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	119/238 (50%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	460/1394 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650