DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC11

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001319112.1	Gene:	ABCC11 / 839922	AraportID:	AT1G30420	Length:	1495	Species:	Arabidopsis thaliana

Alignment Length:	1316	Identity:	449/1316 - (34%)
Similarity:	728/1316 - (55%)	Gaps:	103/1316 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNAS 77
            |...::|||.:.|.:..|....|.:..:..:|:::..:..:.|:|..:....|..  |:.:....
plant   228 PERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCWTE--ESRRPKPW 290

  Fly    78 LLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSAL 142
            |||.|....||.|...|:.....::...|.|:.|..::.|.....|.  .|.|.||..:..|...
plant   291 LLRALNNSLGRRFWLGGIFKVGHDLSQFVGPVILSHILQSMIEGDPA--WVGYVYAFLIFFGVTF 353

  Fly   143 KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFT 207
            .|:..:.|...|..:|.::|..:.:.|:.|.||||.......::|.:.|:|:.|...:....:..
plant   354 GVLCQSQYFQHVGRVGFRLRSTLVAAIFHKSLRLTNKARKNFASGKVTNMITTDANALQLIAEQL 418

  Fly   208 HYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMT 272
            |.||.||.:.::...|:||::|:|::||...:.|.||.|..:.:|:..|..:....:|||:.|:.
plant   419 HGLWSAPFRIIVSMVLLYQQLGVASIFGSLILFLLIPFQTLIVRKMRKLTKEGLQWTDKRVGIIY 483

  Fly   273 EIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFL---TPVSIFLSLVG- 333
            ||:|.:.::|.||||..||..:...|::|::..|...    |:.:||.|:   |||.:.|...|
plant   484 EILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQ----LLSAFNSFILNSTPVVVTLVSFGV 544

  Fly   334 FVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVV 398
            :||:|..||...||...:.:.|:|:.::...:: ::|.....||::|:::||||
plant   545 YVLLGGDLTPARAFTSLSLFAVLRSPLSTLPNL-ISQAVNANVSLQRIEELLLS----------- 597

  Fly   399 SNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGA 463
                       .|::|....|:: |..|      .:||......|.:.:...|||.:||::..|:
plant   598 -----------EERILAQNPPLQ-PGAP------AISIKNGYFSWDSKTSKPTLSDINLEIPVGS 644

  Fly   464 LVAIVGHTGSGKSSLIQAILGEL-RVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRR 527
            ||||||.||.||:|||.|:|||| ..|:..:::.||::|..|..|:|:.|:|:|||||...:..|
plant   645 LVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILFGSDFESER 709

  Fly   528 YDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSS 592
            |...:...||:.|.:|.|.:|:|.:|:||.::|||||.|:|:||:||.::.||:.|||.||:|:.
plant   710 YWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDDPFSALDAH 774

  Fly   593 VARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDD 657
            ||.::|:.|::..|:.|..:|||:||.||...|:|:::..|.:|..|.:..|.|||..|..::
plant   775 VAHQVFDSCVKHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKSGTLFKKLM-- 837

  Fly   658 PVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGL-------- 714
               :|....|.::..:..|:..|.:...::      .||.|....::|:.:.||:.|
plant   838 ---ENAGKMDATQEVNTNDENISKLGPTVT------IDVSERSLGSIQQGKWGRSMLVKQEERET 893

  Fly   715 -----GVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDAD 774
                 .|.:.|.:|.||.....:::..::.::.|..|...:||.|..::        |..:....
plant   894 GIISWDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIWTDQS--------TPKSYSPG 950

  Fly   775 FEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNR 839
            |.:   .:|.|:....:.||...||...:.::.|:.:||::|...|.||.|.||..||.|.::||
plant   951 FYI---VVYALLGFGQVAVTFTNSFWLISSSLHAAKRLHDAMLNSILRAPMLFFETNPTGRVINR 1012

  Fly   840 FSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDV 904
            ||||:|.:|..:..::...:...........:|.||:.:.|...:...|:.|....:|..||.:|
plant  1013 FSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGIVSTISLWAIMPLLILFYATYIYYQSTSREV 1077

  Fly   905 KRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI 969
            :||::.||||:|:.|..:|||||:|||:.|...: |:.:| :.|.::..:...|||.  ..|:.|
plant  1078 RRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRM-AKING-KSMDNNIRFTLASTSS--NRWLTI 1138

  Fly   970 FCVLF---IAMITLSFFIFPPSS-------AADVGLAITQAMGLTGTVQWTVRQSAELENTMISV 1024
            .....   :..:|.:|.:....:       |:.:||.::..:.:|..:...:||:::.||::.||
plant  1139 RSESLGGVMIWLTATFAVLRYGNAENQAVFASTMGLLLSYTLNITTLLSGVLRQASKAENSLNSV 1203

  Fly  1025 ERMIEYEEIEPEGPLEATA---DKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPK 1086
            ||:..|.::    |.||||   :.:|...||.:|.|:|.::.|||.|.|  ..||..|||.:.|.
plant  1204 ERVGNYIDL----PSEATAIIENNRPVSGWPSRGSIQFEDVHLRYRPGL--PPVLHGLSFFVYPS 1262

  Fly  1087 EKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVR 1150
            ||||:||||||||||::|||:|: ....|.:.|||.|....||.|||..:|||||.|||||||||
plant  1263 EKVGVVGRTGAGKSSMLNALYRIVELEKGRILIDDYDVAKFGLTDLRRVLSIIPQSPVLFSGTVR 1327

  Fly  1151 HNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRI 1215
            .|:|||.|::|..||.|||...:|||:.....||:.:::|||.|||||||||:.||||:||.::|
plant  1328 FNIDPFSEHNDADLWEALERAHIKDVIDRNPFGLDAEVSEGGENFSVGQRQLLSLARALLRRSKI 1392

  Fly  1216 LVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELL 1280
            |.:|||||:||.:||:|||.|||.:|:.||:|.:||||:||:|.|::||:.:|:|:|:.:|.|||
plant  1393 LFLDEATASVDVRTDSLIQRTIREEFKSCTMLIIAHRLNTIIDCDKILVLSSGQVLEYDSPQELL 1457

  Fly  1281 TADDTNAFQDLVKQTG 1296
            :. ||:||..:|..||
plant  1458 SR-DTSAFFKMVHSTG 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	441/1299 (34%)
		ABC_membrane	94..360	CDD:294371	79/269 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	87/200 (44%)
		ABC_membrane	736..980	CDD:294371	69/246 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	124/221 (56%)
ABCC11	NP_001319112.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720