DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC5

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_171908.1	Gene:	ABCC5 / 839277	AraportID:	AT1G04120	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1352	Identity:	425/1352 - (31%)
Similarity:	677/1352 - (50%)	Gaps:	139/1352 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWAN-ELETN 72
            |...|...:.:.|.::..:..|....|.|..|..||:.......||:|....|.|:|.. :.|..
plant   225 LKVTPYSTAGLVSLITLSWLDPLLSAGSKRPLELKDIPLLAPRDRAKSSYKVLKSNWKRCKSENP 289

  Fly    73 KKNASLLRVLFRVFGR----YFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYA 133
            .|..||.|.:.:.|.:    ..||.|     |..:::....:|:.....:...........|..|
plant   290 SKPPSLARAIMKSFWKEAACNAVFAG-----LNTLVSYVGPYLISYFVDYLGGKEIFPHEGYVLA 349

  Fly   134 GGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLG 198
            |.......::.:....:...|..||:.:|..:::|:|||.|:|:.......::|.|:|.::.|:.
plant   350 GIFFTSKLIETVTTRQWYMGVDILGMHVRSALTAMVYRKGLKLSSIAKQNHTSGEIVNYMAVDVQ 414

  Fly   199 RMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIR 263
            |:..:..:.|.:|:.|:|.::...::|:.:|||||..:...::.|.:.:.|.|.....:.|....
plant   415 RIGDYSWYLHDIWMLPMQIVLALAILYKSVGIAAVATLVATIISILVTIPLAKVQEDYQDKLMTA 479

  Fly   264 SDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLI----WSFNRFLTP 324
            .|:|||..:|.:..::|:|:.|||..:...:...|.:|...:|...|::..:    ||...|:..
plant   480 KDERMRKTSECLRNMRVLKLQAWEDRYRVRLEEMREEEYGWLRKALYSQAFVTFIFWSSPIFVAA 544

  Fly   325 VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE 389
            |:...|    :.:|..|||.......|.:.:::..:..:..: |:..|:|.||:.|:...|
plant   545 VTFATS----IFLGTQLTAGGVLSALATFRILQEPLRNFPDL-VSMMAQTKVSLDRISGFL---- 600

  Fly   390 VVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSG 454
                        .||:|||  :..:|.|..:         |...:.|.:....|...|...||||
plant   601 ------------QEEELQE--DATVVIPRGL---------SNIAIEIKDGVFCWDPFSSRPTLSG 642

  Fly   455 VNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILF 519
            :.::|..|..||:.|..||||||.|..||||:...|||:.:.|:..|.||..|:.||.:.:||||
plant   643 IQMKVEKGMRVAVCGTVGSGKSSFISCILGEIPKISGEVRICGTTGYVSQSAWIQSGNIEENILF 707

  Fly   520 GQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDD 584
            |.||::.:|..|::.|:|::|.||....|:||:|:||.:||||||.|:.|||::|:||.||||||
plant   708 GSPMEKTKYKNVIQACSLKKDIELFSHGDQTIIGERGINLSGGQKQRVQLARALYQDADIYLLDD 772

  Fly   585 PLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGL 649
            |.||:|:.....||.:.:...|.:|.|:.||||::||..||.|::::.|::...|.|:.|.::|.
plant   773 PFSALDAHTGSDLFRDYILSALAEKTVVFVTHQVEFLPAADLILVLKEGRIIQSGKYDDLLQAGT 837

  Fly   650 DF-------------------------------GIVLDDPVND------NEAAEDRSRTSSITDQ 677
            ||                               .:||.:|.:|      ...|::.....|.:|.
plant   838 DFKALVSAHHEAIEAMDIPSPSSEDSDENPIRDSLVLHNPKSDVFENDIETLAKEVQEGGSASDL 902

  Fly   678 RRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAG--GGFLSFSVVMTFFVCS 740
            :....|...:......:.|.||:::.      |:..:.||:.|..|.  |..:...:
plant   903 KAIKEKKKKAKRSRKKQLVQEEERVK------GKVSMKVYLSYMGAAYKGALIPLII-------- 953

  Fly   741 QGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVL----SIMVTIKRSFLF 801
              ||.....||.  ::.|..|...|..|:..::  ::....:.::.|.|    |:.:.: |:.|.
plant   954 --LAQAAFQFLQ--IASNWWMAWANPQTEGDES--KVDPTLLLIVYTALAFGSSVFIFV-RAALV 1011

  Fly   802 FNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLP----TIIMTVIQDF 862
            ....:.|:.:|..:|.|.:.||.|.||:..|||.||||.|.|...||..:|    ....|.||
plant  1012 ATFGLAAAQKLFLNMLRSVFRAPMSFFDSTPAGRILNRVSIDQSVVDLDIPFRLGGFASTTIQ-- 1074

  Fly   863 LLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLS 927
             |.|...::..:...:||: .:...:..::::.:|:.:|.::.|:.:..:||:...|..|:.|.:
plant  1075 -LCGIVAVMTNVTWQVFLL-VVPVAVACFWMQKYYMASSRELVRIVSIQKSPIIHLFGESIAGAA 1137

  Fly   928 TIRAFGAGSILEAEFDGYQ----DMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFP-- 986
            |||.||.    |..|....    |......:..|:........|::...|..|...:....||
plant  1138 TIRGFGQ----EKRFIKRNLYLLDCFVRPFFCSIAAIEWLCLRMELLSTLVFAFCMVLLVSFPHG 1198

  Fly   987 ---PSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPH 1048
               ||.|   |||:|..:.|.|.:...:....:|||.:||:||:.:|.:|..|.| ....|.:|.
plant  1199 TIDPSMA---GLAVTYGLNLNGRLSRWILSFCKLENKIISIERIYQYSQIVGEAP-AIIEDFRPP 1259

  Fly  1049 ESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYN 1112
            .|||..|.||.|::.:||...|  .:||..:|.|....:|:|||||||:|||:||.||||| ...
plant  1260 SSWPATGTIELVDVKVRYAENL--PTVLHGVSCVFPGGKKIGIVGRTGSGKSTLIQALFRLIEPT 1322

  Fly  1113 DGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVV 1177
            .|.:.||:.|.:.:|||||||::.||||:|.||.||:|.||||.:|:|||::|.||::.:|.|||
plant  1323 AGKITIDNIDISQIGLHDLRSRLGIIPQDPTLFEGTIRANLDPLEEHSDDKIWEALDKSQLGDVV 1387

  Fly  1178 ASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFR 1242
            ......|::.:.|.|.|:||||||||.|.||:|:..:|||:|||||:||..||.|||..||.:|.
plant  1388 RGKDLKLDSPVLENGDNWSVGQRQLVSLGRALLKQAKILVLDEATASVDTATDNLIQKIIRTEFE 1452

  Fly  1243 ECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQ 1294
            :|||.|:|||:.|::|||.|||:..|||.||.||..|| .|.::.|..||.:
plant  1453 DCTVCTIAHRIPTVIDSDLVLVLSDGRVAEFDTPARLL-EDKSSMFLKLVTE 1503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	419/1334 (31%)
		ABC_membrane	94..360	CDD:294371	59/269 (22%)
		ABCC_MRP_domain1	434..634	CDD:213217	90/199 (45%)
		ABC_membrane	736..980	CDD:294371	61/255 (24%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	118/221 (53%)
ABCC5	NP_171908.1	MRP_assoc_pro	229..1493	CDD:188098	420/1336 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720