DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcb11

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_113948.1	Gene:	Abcb11 / 83569	RGDID:	619930	Length:	1321	Species:	Rattus norvegicus

Alignment Length:	1301	Identity:	314/1301 - (24%)
Similarity:	535/1301 - (41%)	Gaps:	272/1301 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 GVILGSALKVILMNPYS---FAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEI---STGHIINLI 193
            |:..|..:.|:::..:.   :.:|  |.:....:..:.:|:.:|:   ::|..   |.|.:.:..
  Rat   143 GIYAGVGMTVLILGYFQIRLWVIT--GARQIRRMRKIYFRRIMRM---EIGWFDCTSVGELNSRF 202

  Fly   194 SNDLGRMDTFI--QFTHYL-----------------WLAPLQALMVTYLMYQEIGI-AAVFGMTF 238
            ::|:.:::..|  |..|:|                 |...|..|.|:.|    ||| |||.|::.
  Rat   203 ADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPL----IGIGAAVIGLSI 263

  Fly   239 ILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELP----FEKMVAHARH 299
                        .|.:.|.||...::..   |..|:::.|:.:..:..|..    :||.:..|:.
  Rat   264 ------------AKFTELELKAYAKAGS---IADEVLSSIRTVAAFGGENKEVERYEKNLVFAQR 313

  Fly   300 ----KEINSIRHVAYAKCLI--------WSFNRFL------TP---VSIFLSLVGFVLMGRFLTA 343
                |.:.......|..|||        |..:..:      ||   |.|||.
  Rat   314 WGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLC------------- 365

  Fly   344 EVAFLITAYYNVVR-TNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVS--NGAEED 405
                :|.|..|:.. ::....||.|.:.......:|.|              :.|:.  :|....
  Rat   366 ----VILAAMNIGHASSCLEIFSTGCSAATNIFQTIDR--------------QPVIDCMSGDGYK 412

  Fly   406 LQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGH 470
            |...:.::.........|.:|           ::|          .|..:::.:..|...|:||.
  Rat   413 LDRIKGEIEFHNVTFHYPSRP-----------DVK----------ILDNLSMVIKPGETTALVGS 456

  Fly   471 TGSGKSSLIQAIL-------GELRVESGEIE------VTGSMSYASQEPWLFSGTVRQNILFGQP 522
            :|:|||:.:|.|.       |.:.::..:|.      :...:....|||.|||.|:.:||.||:.
  Rat   457 SGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGRE 521

  Fly   523 MDRRRYDLV-VRKCALERDFEL-LPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDP 585
             |....|:| ..|.|...:|.: ||.:..|::|:.|..:|||||.|:::||::.|:..|.|||..
  Rat   522 -DATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMA 585

  Fly   586 LSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYES-LHKSGL 649
            .||:|:....|: :|.|........:|.|.|:|..::.||.|:..|.|.....||:|. |.:.|:
  Rat   586 TSALDNESEARV-QEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGV 649

  Fly   650 DFGIVLDDPVNDN----------EAAEDRS--RT---SSITDQRRSSVK-------SVLSH---- 688
            .|.:|......||          :|.|..:  ||   .|..|..|:|::       |:|:|
  Rat   650 YFMLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPL 714

  Fly   689 ---------AESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLA 744
                     .:|...||..|:   ::...:.|               .|.:::....::....|:
  Rat   715 AVADHKSSYKDSKDNDVLVEE---VEPAPVRR---------------ILKYNIPEWHYILVGSLS 761

  Fly   745 SLGDYFLSPWVSRNEKMVAHNYT-TDAKDADFEMHAAYIYMLIT-VLSIMVTIKRSFLFFNLAMR 807
            :..:..::|..|.....:...:: .|.:....|:|:..::.:|. .:||.....:.:.|......
  Rat   762 AAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGEL 826

  Fly   808 ASIQLHNSMFRGISRASMYFFN--KNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNII 870
            .:.:|....|:.:....:.:|:  :|..|.:..|.:.|..||.....:.:..::..|.    |||
  Rat   827 LTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFT----NII 887

  Fly   871 ---VIA---------IVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASL 923
               :||         |:...|...||:..:....|..|   .|.|.:.||.:.:        .:.
  Rat   888 AALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGF---ASQDKQALEKAGQ--------ITS 941

  Fly   924 NGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLF---IAMITLSFFIF 985
            ..||.||.. ||..:|..|....::....||. .:..:|..|.:   |..|   ||.:.
  Rat   942 EALSNIRTV-AGIGVEGRFIKAFEVELQTSYK-TAVRKANIYGL---CFAFSQGIAFLA------ 995

  Fly   986 PPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEAT-----ADK 1045
             .|:|...|..:....||..:..:.|..|..|..|  :|.|...|.....:..:.|.     .|:
  Rat   996 -NSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSAT--AVGRTFSYTPSYAKAKISAARFFQLLDR 1057

  Fly  1046 KP--------HESWPE-QGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSS 1101
            ||        .|.|.. ||||:|::....| |......||..||..:.|.:.:..||.:|.|||:
  Rat  1058 KPPINVYSEAGEKWDNFQGKIDFIDCKFTY-PSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKST 1121

  Fly  1102 LINALFRLSYND-GSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNL---DPFDEYSDD 1162
            .|..|.|....| |:|.||..|:..:.:..|||.|.|:.||||||..::..|:   |...|.|.:
  Rat  1122 SIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVE 1186

  Fly  1163 RLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDP 1227
            |...|.::.:|.|.|.|:....||.:...||..|.|::|.:.:||||:||.:||::||||:.:|.
  Rat  1187 RAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDT 1251

  Fly  1228 QTDALIQATIRNKFRE-CTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDL 1291
            :::..:| |..:|.|| .|.:.:||||.||.:||.:.|:..|.|:|.||..:|:.  ...|:..|
  Rat  1252 ESEKTVQ-TALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMA--QKGAYYKL 1313

  Fly  1292 V 1292
            |
  Rat  1314 V 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	311/1288 (24%)
		ABC_membrane	94..360	CDD:294371	53/276 (19%)
		ABCC_MRP_domain1	434..634	CDD:213217	63/214 (29%)
		ABC_membrane	736..980	CDD:294371	51/262 (19%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	86/225 (38%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	310/1292 (24%)
Abcb11	NP_113948.1	Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	651..674		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000