DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1313	Identity:	415/1313 - (31%)
Similarity:	670/1313 - (51%)	Gaps:	113/1313 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANE--LETNKK---- 74
            ::.:||.||||:......:|....|..:|:....||.|||:     |.|...|  :|..::
plant   209 KAGLFSTLSFWWLNSLIKRGNVKDLEEEDIPELRKEERAET-----CYSLFEENLIEQKRRLGSS 268

  Fly    75 -NASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVI- 137
             ..|:|:|......|..:..|...|...|.::..|:.|...|      .......::.|.|.|:
plant   269 CQPSILKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFI------LVAEGNASFRYEGLVLA 327

  Fly   138 ----LGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLG 198
                ....::.:....:.|....:||::|..:::.|.:|.|||..:.....|...|:|..:.|..
plant   328 VLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAY 392

  Fly   199 RMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIR 263
            |:..|..:.|.||....|.|:...:::..:|:|....:..|:|.:.....:.|..:..:.:....
plant   393 RIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTS 457

  Fly   264 SDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHV----AYAKCLIWSFNRFLTP 324
            .|:|::...|.:..::|:|:||||..|:|::...|:.|:.|::.|    ||...|.||     :|
plant   458 QDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWS-----SP 517

  Fly   325 VSIFLSLVGFV---LMGRFLTAEVAFLITAYYNVVRTNMTAYFSV-GVTQTAETLVSIKRVQKLL 385
            |  |:|...|.   .:...|.|...|...|...:|:..:.....| |||..|:  |:..|:...|
plant   518 V--FVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPDVIGVTIQAK--VAFSRIATFL 578

  Fly   386 LSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKW-TTNSPD 449
            .:.|:         .|.|...::..|                 .:::.:.|......| ...|..
plant   579 EAPEL---------QGGERRRKQRSE-----------------GNQNAIIIKSASFSWEEKGSTK 617

  Fly   450 YTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVR 514
            ..|..|:|:|..|..||:.|..|||||:|:.|||||....||.|:..|:::|.||..|:.:||:|
plant   618 PNLRNVSLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIR 682

  Fly   515 QNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASI 579
            .|||||..||..||...::|.:|::|.||||..|:|.:|:||.:||||||.||.|||::|:||.|
plant   683 DNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADI 747

  Fly   580 YLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESL 644
            ||||||.||||:..|..||:|.:...|..|.|:|||||:.||...|.:::|..|::....||:.|
plant   748 YLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQEL 812

  Fly   645 HKSGLDFGIVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQL 709
            .....||    .|.||.:.......|..::.:..: .||.:.....|..:.:...:.|..:.::.
plant   813 LARSRDF----QDLVNAHRETAGSERVVAVENPTK-PVKEINRVISSQSKVLKPSRLIKQEEREK 872

  Fly   710 GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCS--QGLASLGDYFLSPWVSRNEKMVAHNYTTDAKD 772
            |..||..|:.|.....|::      .||:.|  |...::|....:.|::.|   |.:...:..|
plant   873 GDTGLRPYIQYMNQNKGYI------FFFIASLAQVTFAVGQILQNSWMAAN---VDNPQVSTLK- 927

  Fly   773 ADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSIL 837
                  ...:|:||.:.|::..:.||.....:.|::|..|.:.:...:.||.|.|::..|.|.||
plant   928 ------LILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRIL 986

  Fly   838 NRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSL 902
            :|.|.|:..||..:|..::.|:...:..|.::.|:|||....|..::....:.:.|:.:|.:|:.
plant   987 SRVSSDLSIVDLDVPFGLIFVVASSVNTGCSLGVLAIVTWQVLFVSVPMVYLAFRLQKYYFQTAK 1051

  Fly   903 DVKRLEASTRSPVYSHFAASLNGLSTIRAFG------AGSILEAEFDGYQDMHSSASYMF----I 957
            ::.|:..:|||.|.:|.|.|:.|..|||||.      ..|:...:.:.....||.|:..:    :
plant  1052 ELMRINGTTRSYVANHLAESVAGAITIRAFDEEERFFKKSLTLIDTNASPFFHSFAANEWLIQRL 1116

  Fly   958 STSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMI 1022
            .|..|.......||::.:...|.        |:..:|:|::..:.|...:.::|:....|.|.:|
plant  1117 ETVSAIVLASTAFCMILLPTGTF--------SSGFIGMALSYGLSLNMGLVYSVQNQCYLANWII 1173

  Fly  1023 SVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKE 1087
            ||||:.:|..:.||.| |...:.:|..:||..|::|..:|.:||.  .:|..|||.:|...:...
plant  1174 SVERLNQYTHLTPEAP-EVIEETRPPVNWPVTGRVEISDLQIRYR--RESPLVLKGISCTFEGGH 1235

  Fly  1088 KVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRH 1151
            |:|||||||:||::||:||||| ....|.:.:|..|.:.:|:|||||:..||||:|.||:||||.
plant  1236 KIGIVGRTGSGKTTLISALFRLVEPVGGKIVVDGVDISKIGVHDLRSRFGIIPQDPTLFNGTVRF 1300

  Fly  1152 NLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRIL 1216
            ||||..::||..:|..|.:.:||:||.....||::.:.|.|||:|:|||||.||.||:||.:|:|
plant  1301 NLDPLCQHSDAEIWEVLGKCQLKEVVQEKENGLDSLVVEDGSNWSMGQRQLFCLGRAVLRRSRVL 1365

  Fly  1217 VMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLT 1281
            |:|||||::|..||.::|.|||.:|.:|||:|||||:.|:||...||.:..||:||:..|.:|:
plant  1366 VLDEATASIDNATDLILQKTIRREFADCTVITVAHRIPTVMDCTMVLSISDGRIVEYDEPMKLM- 1429

  Fly  1282 ADDTNAFQDLVKQ 1294
            .|:.:.|..|||:
plant  1430 KDENSLFGKLVKE 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	410/1298 (32%)
		ABC_membrane	94..360	CDD:294371	64/277 (23%)
		ABCC_MRP_domain1	434..634	CDD:213217	95/200 (48%)
		ABC_membrane	736..980	CDD:294371	64/255 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	110/221 (50%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	411/1306 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720