DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC8

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1335	Identity:	424/1335 - (31%)
Similarity:	676/1335 - (50%)	Gaps:	126/1335 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERS------NIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW-- 65
            |.:|||:.|      ..||.|||.:..|....|.|..|..:|:...:.|..|:....|...:|
plant   198 LTKNPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDT 262

  Fly    66 --ANELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLIS-SFSNPSPTSNG 127
              .:|..|.::|. :.|.:.:|:.:..:|:.:..|.....:...|:.|...:. :.|:.....||
plant   263 LLGDESSTKERNL-VFRAVVKVYFKENIFIAVFAFLRTFAVVSLPLMLYVFVDYANSDHRDLRNG 326

  Fly   128 VAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINL 192
              :.....:::...::.:.|..:.||....|::||..:....|:|.|:|:.......|:|.|:|.
plant   327 --FFNLACLVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGEIVNY 389

  Fly   193 ISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLR 257
            |:.|..||..|:.:.|..|...||.|:.|.:::..:|..|..|:..:||...|.:...|.:...:
plant   390 IAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLLNLPFAKMLQNCQ 454

  Fly   258 LKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHV----AYAKCLIWSF 318
            .:..|..|||:|..:||:..::|||:.:||..|:|.:...|..|...:...    |:...|.|..
plant   455 TQFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLAKAQLTKAFGSFLYWMS 519

  Fly   319 NRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQK 383
            ...::.| :||...  :|....|.|...|.:.|...|: :.........::...:..||.:|:..
plant   520 PTIVSSV-VFLGCA--LLKSAPLNASTIFTVLATLRVM-SEPVKIIPDAISAIIQGNVSFQRLNN 580

  Fly   384 LLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSP 448
            .||..|:  |.:.:..:|.:.                         |...|.|......|...:.
plant   581 FLLDDEL--KMDEIERSGLDA-------------------------SGTAVDIQVGNFGWEPETK 618

  Fly   449 DYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTV 513
            ..||..::|::..|..||:.|..|:|||||:.|:|||:...||.::|.||::|.||..|:.|||:
plant   619 IPTLRNIHLEIKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYVSQTSWIQSGTI 683

  Fly   514 RQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDAS 578
            |.|||:|:||:.|||:..::.|||::|.......|.|.:|.||.:||||||.||.|||:||.||.
plant   684 RDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRIQLARAVYADAD 748

  Fly   579 IYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYES 643
            :||||||.||||:..|..||.:|:...|::|.|||||||::||.:.|||::||.|.:...|.||.
plant   749 VYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEFLSEVDQILVMEEGTITQSGKYEE 813

  Fly   644 LHKSGLDFGIVLDD--------PVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQ 700
            |...|..|..:::.        |:..||:..|..:.....:.|..:|...:.. |....|:...|
plant   814 LLMMGTAFQQLVNAHNDAVTVLPLASNESLGDLRKEGKDREIRNMTVVEKIEE-EIEKTDIPGVQ 877

  Fly   701 KINLQRQQLGRNGLGVYVDYFRAGGGF-LSFSVVM--TFFVCSQGLASLGDYFLS-----PWVSR 757
            ....:.::.|..|:..::||.....|: |.:|.|:  ..||..|..::   |:|:     |.::.
plant   878 LTQEEEKESGYVGMKPFLDYIGVSRGWCLLWSSVLGQVGFVVFQAAST---YWLAFAIGIPKITN 939

  Fly   758 NEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLF------FNLAMRASIQLHNSM 816
            .                         |||.|.||:.|:...|::      .:|.::||....:..
plant   940 T-------------------------MLIGVYSIISTLSAGFVYARAITTAHLGLKASKAFFSGF 979

  Fly   817 FRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLI 881
            ...:.:|.|.||:..|.|.||.|.|.|:..:|..:|...:.|:...:.....::::..|....:|
plant   980 TNAVFKAPMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFVVAPAVELTAALLIMTYVTWQVII 1044

  Fly   882 PALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQ 946
            .||........::.:||.::.::.|:..:|::||.::.|.:..|:.||||||..   |..|..|.
plant  1045 IALLALAATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTIRAFGTA---ERFFKNYL 1106

  Fly   947 DMHSSASYMFISTSRAFAYW----------MDIF-CVLFIAMITLSFFIFPPSSAADVGLAITQA 1000
            ::..:.:.:|. .|.|...|          :.:| |.|.:.:|...:.     :...|||:::.|
plant  1107 NLVDADAVLFF-LSNAAMEWVILRIETLQNVTLFTCALLLILIPKGYI-----APGLVGLSLSYA 1165

  Fly  1001 MGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLR 1065
            :.||.|..:..|....|.|::|||||:.:|..| ||.|.....||:|..|||..|.|...||.:|
plant  1166 LTLTQTQVFLTRWYCTLSNSIISVERIKQYMNI-PEEPPAIIDDKRPPSSWPSNGTIHLQELKIR 1229

  Fly  1066 YEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLH 1129
            |.|  .:..|||.:|...:...:||:|||||:|||:||:||||| ....|.:.||..|.:.:||.
plant  1230 YRP--NAPLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCILIDGIDISKIGLK 1292

  Fly  1130 DLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSN 1194
            |||.|:|||||||.||.|.:|.||||...||||.:|.|||:.:||..::::...|::.:::.|.|
plant  1293 DLRMKLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPNKLDSSVSDEGEN 1357

  Fly  1195 FSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDS 1259
            :|||||||.||.|.:|:.|:|||:|||||::|..|||:||..||.:|.:|||:|||||:.|::||
plant  1358 WSVGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVITVAHRVPTVIDS 1422

  Fly  1260 DRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQ 1294
            |.|:|:..|.:||:..|.:|:..|  :.|..||.:
plant  1423 DMVMVLSFGDLVEYNEPSKLMETD--SYFSKLVAE 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	419/1317 (32%)
		ABC_membrane	94..360	CDD:294371	66/270 (24%)
		ABCC_MRP_domain1	434..634	CDD:213217	96/199 (48%)
		ABC_membrane	736..980	CDD:294371	60/265 (23%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	112/221 (51%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720