DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC7

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_187917.3	Gene:	ABCC7 / 820498	AraportID:	AT3G13100	Length:	1493	Species:	Arabidopsis thaliana

Alignment Length:	1356	Identity:	443/1356 - (32%)
Similarity:	689/1356 - (50%)	Gaps:	147/1356 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESL----GNKLCSSWAN 67
            :|....|...:...|.:||.:..|..:.|.:..:.::|:.:.....|||.|    .:||  .| :
plant   225 DDEVVTPFSNAGFLSHVSFSWMSPLIVLGNEKIIDSEDVPQVDNSDRAEKLFWIFRSKL--EW-D 286

  Fly    68 ELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAY 132
            :.|.......|::.||....|..:...|..|...|...|.|..:...:...:.....||
plant   287 DGERRITTYKLIKALFFSVWRDILLSTLFAFVYTVSCYVAPYLMDTFVQYLNGQRQYSN------ 345

  Fly   133 AGGVILGSALKVILM-------NPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHII 190
             .||:|.:...|..:       |.| |.:...|:.:|..:.||||.|.|.|........::|.||
plant   346 -QGVVLVTTFFVAKLVECQARRNWY-FRLQKAGIGMRSVLVSMIYEKGLTLPCYSKQGHTSGEII 408

  Fly   191 NLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIA--AVFGMTFILLF--IPLQMYLGK 251
            ||::.|..|:..|..:.|..|:..||..:...::|:.:|:.  |.|..||:::.  |||.. |.:
plant   409 NLMTVDAERISAFSWYMHDPWILVLQISLALLILYRSLGLGSIAAFAATFLVMLGNIPLAK-LEE 472

  Fly   252 KISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIW 316
            |..|..:::   .|.||:..:|.:..::::|:..||:.|...:...|..|...::...|....|.
plant   473 KFQGNLMES---KDNRMKKTSEALLNMRILKLQGWEMKFLHKILDLRGIEAGWLKKFVYNSAAIS 534

  Fly   317 SFNRFLTPVSIFLSLVGF---VLM------GRFLTAEVAFLI--TAYYNVVRTNMTAYFSVGVTQ 370
            |   .|.....|:|...|   :|:      |:.:.|...|.|  |..|.:..|         ::.
plant   535 S---VLWAAPSFVSATAFGACMLLKIPLESGKIIAALATFRILQTPIYKLPDT---------ISM 587

  Fly   371 TAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDL-QEAREKLLVTPTPMRAPEKPPHNSEDCV 434
            ..:|.||:.|:...|                ..:|| |:..|:|            |..:|:..|
plant   588 IVQTKVSLDRIATFL----------------CLDDLQQDGMERL------------PSGSSKMDV 624

  Fly   435 SISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSM 499
            .:|.....|..:||..||..:..::..|..:||.|..|||||||:.:||||:...||.::|.|..
plant   625 EVSNGAFSWDDSSPIPTLKDIRFKIPHGMNIAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRK 689

  Fly   500 SYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQK 564
            :|.:|.||:.||.|.:|||||:||.|..|..|:..|:|.:|.|:.|.:|:|::|:||.:||||||
plant   690 AYIAQSPWIQSGKVEENILFGKPMQREWYQRVLEACSLNKDLEVFPFRDQTVIGERGINLSGGQK 754

  Fly   565 ARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVI 629
            .||.:||::|:||.|||.|||.||||:.....||:|.|.|.||:|.||.|||||:||.:||.|::
plant   755 QRIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRNKTVIYVTHQLEFLPEADLILV 819

  Fly   630 MEMGKVKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVLSH-----A 689
            |:.|::...|.|..:.:||.|| :.|.....|..||.|.....|.:.|..:|.:|.:|:     .
plant   820 MKDGRITQAGKYNEILESGTDF-MELVGAHTDALAAVDSYEKGSASAQSTTSKESKVSNDEEKQE 883

  Fly   690 ESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPW 754
            |..|...|  |.:..:.::.|:.|..||..|.:...|.....:::...:..|.| ::|..:...|
plant   884 EDLPSPKG--QLVQEEEREKGKVGFTVYQKYMKLAYGGALVPIILVVQILFQVL-NIGSNYWMAW 945

  Fly   755 VSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRG 819
            |:...|        |.|..........:|:.:...|....:.|:.|......:.:.:|.|.|...
plant   946 VTPVSK--------DVKPLVSGSTLILVYVFLATASSFCILVRAMLSAMTGFKIATELFNQMHFR 1002

  Fly   820 ISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPAL 884
            |.||||.||:..|.|.||||.|.|...||..||:....            :.||.||.|.:|..:
plant  1003 IFRASMSFFDATPIGRILNRASTDQSAVDLRLPSQFSN------------LAIAAVNILGIIGVM 1055

  Fly   885 ---AFGIVIYYL---------RSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSI 937
               |:.::|.::         |.:|:..:.::.||...:|||:..||:.:|:|::|||:|.....
plant  1056 GQVAWQVLIVFIPVIAACTWYRQYYISAARELARLSGISRSPLVQHFSETLSGITTIRSFDQEPR 1120

  Fly   938 LEAEFDGYQDMHSSASYMFISTSRAFAYWMDI-----FCVLFIAMITLSFFIFPPSSAADVGLAI 997
            ...:.....|.:|...:..||......:.:|:     |.:..:.::::...:..||.|   |||:
plant  1121 FRTDIMRLNDCYSRLRFHAISAMEWLCFRLDLLSTVAFALSLVILVSVPEGVINPSFA---GLAV 1182

  Fly   998 TQAMGLT---GTVQWTVRQSAELENTMISVERMIEYEEI--EPEGPLEATADKKPHESWPEQGKI 1057
            |.|:.|.   .|:.||:   .:|||.|||||||::|.:|  ||...:|:|   :|.:|||.:|:|
plant  1183 TYALNLNSLQATLIWTL---CDLENKMISVERMLQYIDIPSEPSLVIEST---RPEKSWPCRGEI 1241

  Fly  1058 EFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDK 1121
            ....|.:||.|:|  ..||:.|:...:...|.|||||||.|||:||..|||: ....|.:|||..
plant  1242 TICNLQVRYGPHL--PMVLRGLTCTFRGGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGI 1304

  Fly  1122 DTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLET 1186
            :...:|||||||::|||||||.:|.||||.||||.:||:||::|.||::.:|.|.:......|::
plant  1305 NILTIGLHDLRSRLSIIPQEPTMFEGTVRSNLDPLEEYADDQIWEALDKCQLGDEIRKKELKLDS 1369

  Fly  1187 KITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAH 1251
            .::|.|.|:||||||||||.|.:|:.:::|::|||||:||..||.|||.|:|..|..|||:|:||
plant  1370 PVSENGQNWSVGQRQLVCLGRVLLKRSKVLILDEATASVDTATDTLIQETLRQHFSGCTVITIAH 1434

  Fly  1252 RLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKIS 1307
            |:.:::|||.||::|.|.:.|..:|..|| .|.:::|..||.:. .|:.|:..|.|
plant  1435 RISSVIDSDMVLLLDQGLIEEHDSPARLL-EDKSSSFSKLVAEY-TASSDSRFKRS 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	433/1323 (33%)
		ABC_membrane	94..360	CDD:294371	72/287 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	97/199 (49%)
		ABC_membrane	736..980	CDD:294371	63/260 (24%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	109/221 (49%)
ABCC7	NP_187917.3	PLN03232	34..1474	CDD:215640	437/1339 (33%)
		ABC_membrane	309..578	CDD:294371	70/283 (25%)
		ABCC_MRP_domain1	624..824	CDD:213217	97/199 (49%)
		ABC_membrane	925..1199	CDD:294371	74/297 (25%)
		ABCC_MRP_domain2	1239..1459	CDD:213211	109/221 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720