DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC6

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_187916.3	Gene:	ABCC6 / 820497	AraportID:	AT3G13090	Length:	1466	Species:	Arabidopsis thaliana

Alignment Length:	1366	Identity:	449/1366 - (32%)
Similarity:	676/1366 - (49%)	Gaps:	171/1366 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESL----GNKLC 62
            :|..||::.. |..::.|.|.:||.:..|....|.:..:..||:.:..:....|||    .:||
plant   198 ESSDNEEVTA-PFSKAGILSRMSFSWMSPLITLGNEKIIDIKDVPQLDRSDTTESLFWIFRSKL- 260

  Fly    63 SSWANELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNG 127
             .| ::.|.......|::.||....|..|...|:.|...|...|.| :||.....:.|.:.....
plant   261 -EW-DDGERRITTFKLIKALFLSVWRDIVLSALLAFVYTVSCYVAP-YLMDNFVQYLNGNRQYKN 322

  Fly   128 VAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINL 192
            ..|.......:...::......:.|.....||.:|..:.||||.|.|.|........::|.||||
plant   323 QGYVLVTTFFVAKLVECQTQRQWFFRGQKAGLGMRSVLVSMIYEKGLTLPCHSKQGHTSGEIINL 387

  Fly   193 ISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIA--AVFGMTFILLFIPLQMY----LGK 251
            ::.|..|:..|..|.|..|:..||..:..:::|:.:|:.  |.|..|.:::   |..|    |.:
plant   388 MAVDADRISAFSWFMHDPWILVLQVSLALWILYKSLGLGSIAAFPATILVM---LANYPFAKLEE 449

  Fly   252 KISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIW 316
            |.....:|:   .|.||:..:|::..::::|:..||:.|...:...||.|...::...|....|
plant   450 KFQSSLMKS---KDNRMKKTSEVLLNMKILKLQGWEMKFLSKILELRHIEAGWLKKFVYNSSAI- 510

  Fly   317 SFNRFLTPVSIFLSLVGF---VLM------GRFLTAEVAFLIT--AYYNVVRTNMTAYFSVGVTQ 370
              |..|.....|:|...|   :|:      |:.|.|...|.|.  ..|.:..|         ::.
plant   511 --NSVLWAAPSFISATAFGACLLLKIPLESGKILAALATFRILQGPIYKLPET---------ISM 564

  Fly   371 TAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVS 435
            ..:|.||:.|:...|                ..:|||:.....|           |..:||..|.
plant   565 IVQTKVSLNRIASFL----------------CLDDLQQDVVGRL-----------PSGSSEMAVE 602

  Fly   436 ISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMS 500
            ||.....|..:||..||..:|.:|..|..|||.|..|||||||:.:||||:...||.::|.|..:
plant   603 ISNGTFSWDDSSPIPTLRDMNFKVSQGMNVAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKA 667

  Fly   501 YASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKA 565
            |.:|.||:.||.|.:|||||:||:|..||.|:..|:|.:|.|:||..|:|::|:||.:||||||.
plant   668 YIAQSPWIQSGKVEENILFGKPMEREWYDRVLEACSLNKDLEILPFHDQTVIGERGINLSGGQKQ 732

  Fly   566 RISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIM 630
            ||.:||::|:||.|||.|||.||||:.....||:|.|.|.||.|.||.||||::||.:||.|::|
plant   733 RIQIARALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRHKTVIYVTHQVEFLPEADLILVM 797

  Fly   631 EMGKVKAVGTYESLHKSGLDF---------GIVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVL 686
            :.||:...|.|..:..||.||         .:...|......|:|     .|.||:.    ..||
plant   798 KDGKITQAGKYHEILDSGTDFMELVGAHTEALATIDSCETGYASE-----KSTTDKE----NEVL 853

  Fly   687 SHAESCPEDVGEEQK-----INLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASL 746
            .|.|.  ::.|.:.|     :..:.::.|:.|..||..|.....|.....:::...|..| |.|:
plant   854 HHKEK--QENGSDNKPSGQLVQEEEREKGKVGFTVYKKYMALAYGGAVIPLILVVQVLFQ-LLSI 915

  Fly   747 GDYFLSPWVSRNEKMVAHNYTTDAKDAD-----FEMHAAYIYMLITVLSIMVTIKRSFLFFNLAM 806
            |..:...||           |..:||.:     |.:  ..:|:|:.|.|....:.|:.|......
plant   916 GSNYWMTWV-----------TPVSKDVEPPVSGFTL--ILVYVLLAVASSFCILIRALLVAMTGF 967

  Fly   807 RASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNI-- 869
            :.:.:|...|...|.||||.||:..|.|.||||.|.|....|..||              |..
plant   968 KMATELFTQMHLRIFRASMSFFDATPMGRILNRASTDQSVADLRLP--------------GQFAY 1018

  Fly   870 IVIAIVNPLFLIPAL---AFGIVIYYL---------RSFYLKTSLDVKRLEASTRSPVYSHFAAS 922
            :.||.:|.|.:|..:   |:.::|.::         |.:|:..:.::.||...:||||..||:.:
plant  1019 VAIAAINILGIIGVIVQVAWQVLIVFIPVVAACAWYRQYYISAARELARLAGISRSPVVHHFSET 1083

  Fly   923 LNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI-----FCVLFIAMITLSF 982
            |:|::|||:|........:.....|.:|...:..........:.:::     |....:.:::...
plant  1084 LSGITTIRSFDQEPRFRGDIMRLSDCYSRLKFHSTGAMEWLCFRLELLSTFAFASSLVILVSAPE 1148

  Fly   983 FIFPPSSAADVGLAITQAMGLT---GTVQWTVRQSAELENTMISVERMIEYEEIEPEGPL--EAT 1042
            .:..||.|   |||||.|:.|.   .|:.||:   .:|||.|||||||::|..|..|.||  |.|
plant  1149 GVINPSLA---GLAITYALNLNTLQATLIWTL---CDLENKMISVERMLQYTNIPSEPPLVIETT 1207

  Fly  1043 ADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALF 1107
               :|.:|||.:|:|....|.:||.|:|  ..||..|:.......|.|||||||.|||:||..||
plant  1208 ---RPEKSWPSRGEITICNLQVRYGPHL--PMVLHGLTCTFPGGLKTGIVGRTGCGKSTLIQTLF 1267

  Fly  1108 RL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEV 1171
            |: ....|.:|||..:...:|||||||::|||||:|.:|.||:|.||||.:||:||::|.||:..
plant  1268 RIVEPAAGEIRIDGINILSIGLHDLRSRLSIIPQDPTMFEGTIRSNLDPLEEYTDDQIWEALDNC 1332

  Fly  1172 ELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQAT 1236
            :|.|.|......|::.::|.|.|:||||||||||.|.:|:.:::||:|||||::|..||.|||.|
plant  1333 QLGDEVRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKLLVLDEATASIDTATDNLIQET 1397

  Fly  1237 IRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYD 1301
            :|:.|.:|||:|:|||:.:::|||.||::|.|.:.|..:|..|| .|.::.|..||     |.|.
plant  1398 LRHHFADCTVITIAHRISSVIDSDMVLLLDQGLIKEHDSPARLL-EDRSSLFSKLV-----AEYT 1456

  Fly  1302 T 1302
            |
plant  1457 T 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	438/1333 (33%)
		ABC_membrane	94..360	CDD:294371	69/282 (24%)
		ABCC_MRP_domain1	434..634	CDD:213217	102/199 (51%)
		ABC_membrane	736..980	CDD:294371	64/267 (24%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	108/221 (49%)
ABCC6	NP_187916.3	PLN03232	67..1452	CDD:215640	444/1354 (33%)
		ABC_membrane	286..555	CDD:294371	68/278 (24%)
		ABCC_MRP_domain1	601..801	CDD:213217	102/199 (51%)
		ABC_membrane	902..1173	CDD:294371	74/301 (25%)
		ABCC_MRP_domain2	1217..1437	CDD:213211	108/221 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720