DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1336	Identity:	464/1336 - (34%)
Similarity:	720/1336 - (53%)	Gaps:	93/1336 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSFKNEDLPEN----PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKL 61
            :..::.|::.:.    |.:.:|||..:.|.:..|....|.|..|..||::......:.|:|....
plant   211 VDDYEYEEISDGQQICPEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSF 275

  Fly    62 CSSWANELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSN 126
            ..||..||:  |....|||.|....|..|.:.|......:....|.|:.|.:|:.|....:|...
plant   276 QHSWDKELQ--KPQPWLLRALNNSLGGRFWWGGFWKIGNDCSQFVGPLLLNQLLKSMQEDAPAWM 338

  Fly   127 GVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIIN 191
            |  |.||..:.:|....|:....|...|..:|.::|..:.:.::||.||||.....:..||.|.|
plant   339 G--YIYAFSIFVGVVFGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKITN 401

  Fly   192 LISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGL 256
            |::.|...:....|..|.:|.||.:.::...|:||::|:|::.|...::|..|||..:..|:..|
plant   402 LMTTDAESLQQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKL 466

  Fly   257 RLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRF 321
            ..:...|:|||:.:|.|::|.:..:|.||||..|:..|...|..|::..|    ...|:.:.|.|
plant   467 TKEGLQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFR----KSQLLGALNMF 527

  Fly   322 -LTPVSIFLSLVG---FVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQ 382
             |..:.:.:::|.   |.|:|..||...||...:.:.|:|..:....:: :||.....||:||::
plant   528 ILNSIPVLVTIVSFGVFTLLGGDLTPARAFTSLSLFAVLRFPLFMLPNI-ITQVVNANVSLKRLE 591

  Fly   383 KLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNS 447
            ::|                       |.|:.::.|.|...|.:|      .:||......|.:..
plant   592 EVL-----------------------ATEERILLPNPPIEPGEP------AISIRNGYFSWDSKG 627

  Fly   448 PDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEI-EVTGSMSYASQEPWLFSG 511
            ...|||.:||.|..|:|||:||.||.||:|||.||||||...|..| .:.||::|..|..|:|:.
plant   628 DRPTLSNINLDVPLGSLVAVVGSTGEGKTSLISAILGELPATSDAIVTLRGSVAYVPQVSWIFNA 692

  Fly   512 TVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRD 576
            |||.|||||.|.||.:|:..:...:|:.|.||||..|.|.:|:||.::|||||.|:|:||:||.:
plant   693 TVRDNILFGSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSN 757

  Fly   577 ASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY 641
            :.:|:.||||||:|:.|.:::||:|::..|..|..:|||:||.||.|.|:||::..|.||..|||
plant   758 SDVYIFDDPLSALDAHVGQQVFEKCIKRELGQKTRVLVTNQLHFLSQVDRIVLVHEGTVKEEGTY 822

  Fly   642 ESLHKSGLDF-------GIVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPE---DV 696
            |.|..:|..|       |.|.:....:.||..|::....:.:...:.::...|..:...|   ..
plant   823 EELSSNGPLFQRLMENAGKVEEYSEENGEAEADQTAEQPVANGNTNGLQMDGSDDKKSKEGNKKG 887

  Fly   697 GEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKM 761
            |:...|..:.::.|.....|...|..|.||.....:::..:|.::........:||.|
plant   888 GKSVLIKQEERETGVVSWRVLKRYQDALGGAWVVMMLLLCYVLTEVFRVTSSTWLSEW------- 945

  Fly   762 VAHNYTTDAKDADFEMHAAYIYMLITVL----SIMVTIKRSFLFFNLAMRASIQLHNSMFRGISR 822
                  |||...  :.|....|.||..|    .::||:..|:.....::.|:.:||::|...|.|
plant   946 ------TDAGTP--KSHGPLFYNLIYALLSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHSILR 1002

  Fly   823 ASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFG 887
            |.|.||:.||.|.|:|||:||:|.:|..:...:...:.........:::|.||:.|.|...:...
plant  1003 APMSFFHTNPLGRIINRFAKDLGDIDRTVAVFVNMFMGQVSQLLSTVVLIGIVSTLSLWAIMPLL 1067

  Fly   888 IVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSA 952
            ::.|....:|..|:.:|||:::.:|||||:.|..:|||||||||:.|...: |:.:| :.|.::.
plant  1068 VLFYGAYLYYQNTAREVKRMDSISRSPVYAQFGEALNGLSTIRAYKAYDRM-ADING-RSMDNNI 1130

  Fly   953 SYMFIS--TSRAFAYWMDIFCVLFIAMITLSFFIF-------PPSSAADVGLAITQAMGLTGTVQ 1008
            .:..::  .:|.....::....|.| .:|.||.:.       ..:.|:.:||.::.|:.:|..:.
plant  1131 RFTLVNMGANRWLGIRLETLGGLMI-WLTASFAVMQNGRAENQQAFASTMGLLLSYALNITSLLT 1194

  Fly  1009 WTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSE 1073
            ..:|.::..||::.:|||:..|.||.||.| ....:.:|...||..|.|:|.::.|||.|.|  .
plant  1195 GVLRLASLAENSLNAVERVGNYIEIPPEAP-PVIENNRPPPGWPSSGSIKFEDVVLRYRPQL--P 1256

  Fly  1074 SVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISI 1137
            .||..:||.|.|.:|||||||||||||||:|||||: ....|.:.|||.|....||.|||..:.|
plant  1257 PVLHGVSFFIHPTDKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDCDVGKFGLMDLRKVLGI 1321

  Fly  1138 IPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQL 1202
            |||.|||||||||.|||||.|::|..||.:||...|||.:.....||:.:::|.|.|||||||||
plant  1322 IPQSPVLFSGTVRFNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDAEVSEAGENFSVGQRQL 1386

  Fly  1203 VCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDA 1267
            :.|:||:||.::|||:|||||.||.:||||||.|||.:|:.||:|.:||||:||:|.|::||:|:
plant  1387 LSLSRALLRRSKILVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAHRLNTIIDCDKILVLDS 1451

  Fly  1268 GRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTL 1303
            |||.||.:|..|| :::.::|..:|:.||.|..:.|
plant  1452 GRVQEFSSPENLL-SNEGSSFSKMVQSTGAANAEYL 1486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	456/1301 (35%)
		ABC_membrane	94..360	CDD:294371	77/269 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	95/200 (48%)
		ABC_membrane	736..980	CDD:294371	69/249 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	128/221 (58%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	464/1336 (35%)
		ABC_membrane	309..570	CDD:279056	76/266 (29%)
		ABCC_MRP_domain1	614..815	CDD:213217	95/200 (48%)
		ABC_membrane	925..1179	CDD:294371	73/271 (27%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720